Key Words

Dietary Fibre, Endosymbiotic Archaea, Immunity, Autoimmune Disease

Key Sentences

Dietary fibre can regulate body and cell function. Dietary fibre is the substrate that determines symbiosis and symbiotic evolution. The endosymbiotic archaea regulates human functions and species type and depends upon the colonic archaea whose density is determined by the fibre intake. Populations with low fibre intake have lesser density of colonic archaeal microflora and endosymbiotic archaea. Endosymbiotic archaea contributes to neanderthalisation of the species. Populations consuming a high saturated fat and protein diet with low fibre intake tend to get increased endosymbiotic archaeal growth and are neanderthalised. Populations with high fibre intake up to 80 g/day tend to have reduced archaeal density in the colon and reduced archaeal endosymbiosis contributing to homo sapienisation of the population. Thus fibre intake regulates the endosymbiotic archaeal density and type of human species. Dietary fibre deficiency and increased archaeal endosymbiosis can lead to autoimmune diseases like systemic lupus erythematosis, rheumatoid arthritis and multiple sclerosis.

Ravikumar Kurup

Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.

Parameswara Achutha Kurup

The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.