Key Words
Climate Change, Global Warming, Warburg Phenotype, Fructositis, Metabolic Evolution
Key Sentences
Global warming and climate change leads to neanderthalisation of the species and a changeover to neanderthal metabolonomics. Stress of global warming led to the induction of HO1. This results in heme depletion. Heme depletion induces ALA synthase and results in porphyrinogenesis. The archaea can catabolize cholesterol to digoxin, a steroidal hormone. The archaea and its antigens induce HIF alpha and activate the glycolytic pathway. The glycolytic pathway activation induces increased conversion of glucose to fructose by activation of the sorbitol pathway. Glucose is converted to sorbitol by the enzyme aldose reductase and sorbitol is converted to fructose by the action of sorbitol dehydrogenase. Fructose is phosphorylated by hexokinase or fructokinase to fructose phosphate. Hexokinase has a low km value for fructose and minimal amounts of fructose will be converted to fructose phosphate depleting the cellular ATP. ATP is converted to AMP and by the action of AMP deaminase is converted to uric acid. Thus there is resultant hyperuricemia and the depletion of ATP also produces membrane sodium potassium ATPase inhibition. Climate change can induce lasting metabolic evolution.
| The Full Book PDF |
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| FrontMatter |
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| Chapter 1 Climate Change and Human Species-Homo Neanderthalis, Homo Sapiens, Homo Sapien Extinctus and Homo Neoneanderthalis - Role in Metabolic Evolution |
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| Chapter 2 Climate Change and Metabolic Evolution-The Global Warming Related Glycolytic Disease |
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| Chapter 3 Climate Change and Human Energetics-Endosymbiotic Actinidic Archaeal Mediated Warburg Phenotype Mediates Human Disease State |
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| Chapter 4 Climate Change and Lipidology-Endosymbiotic Actinidic Archaeal Cholesterol Catabolic Syndrome - Hypocholesterolemia and Human Diseases |
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| Chapter 5 Climate Change and Membrane Function-Endosymbiotic Actinidic Archaeal Synthesis of Digoxin from Cholesterol Regulates Cellular Function and contributes to Disease Pathology |
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| Chapter 6 Climate Change and Porphyrin Metabolism-Archaeal Porphyrins, Regulation of Cell Function and Neuro-Immuno-Endocrine Integration |
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| Chapter 7 Climate Change and Stem Cell Biology-Glycolysis, Global Warming and Human Stem Cell Transformation |
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| Chapter 8 Climate Change and Cell Structure-The Archaeal Induced Stem Cell Conversion produces an Epidemic Benjamin Buttons Reverse Aging Syndrome leading to Systemic and Neuropsychiatric Diseases and a Spiritual, Surrealistic Evil Brain |
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| Chapter 9 Climate Change and Endocrine System-The Endosymbiotic Archaea, Fructose Disease, Metabolic Syndrome X and Global Warming |
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| Chapter 10 Climate Change and Insulin Action-Neoneanderthalisation and Metabolic Syndrome - Type 2 Diabetes Mellitus with Coronary Artery Disease and Stroke |
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| BackMatter |
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Ravikumar Kurup
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Experts in Metabolonomics, Endocrinology, Medicine, Philosophy, Evolution, Climatology
