Neanderthal genes have been described in the homo sapien population. The Neanderthal brain has a prominent cerebellar cortex and small prefrontal cortex. The Neanderthal brain structure results in female dominance and matriarchal social patterns. It was considered plausible that Neanderthal genomics and metabolonomics could also contribute to androgynous behaviour. Autistic patients tend to have Neanderthal metabolonomics and phenotype. It has been demonstrated that Neanderthal phenotype is due to symbiosis by actinidic archaea using cholesterol as an energy substrate. The actinidic archaea catabolises cholesterol with ring A being oxidized to pyruvate and side chain oxidation resulting in generation of short chain fatty acids. Cholesterol is also converted to steroidogenic estrogens and testosterone. Cholesterol deficiency leads to sex hormone deficiency and an androgynous state. Digoxin produces sodium potassium ATPase inhibition and increased in intracellular calcium inducing nitric oxide synthase and heme oxygenase generating gasotransmitters nitric oxide and carbon monoxide important in smooth muscle contraction and autonomic function. The book deals with assessment of Neanderthal metabolonomics in androgynous individuals.

Experts in Neurology, Psychiatry, Philosophy, Andrology, Psychology, Sexology