The Neanderthals are symbiotic life form due to archaeal endosymbiosis. The archaea induces the Warburg phenotype with increased glycolysis and the blockade of the TCA cycle and mitochondrial oxidative phosphorylation. The Warburg phenotype is seen in autoimmune disease, schizophrenia, autism, cancer, degeneration and metabolic syndrome x. The Neanderthals ate a ketogenic diet of fat and protein to suppress the glycolytic pathway. The Neanderthal hybrids formed by homo sapien mating had a high carbohydrate diet due to grain cultivation in settled colonies. This tends to increased glycolysis and accentuates the Warburg phenotype and associated disorders. The glycolytic pathway is upregulated and the mitochondrial oxidative phosphorylation is inhibited. To counteract this certain disease patterns developed in the hybrid population as a adaptive mechanism. These groups of disorders develop autoantibodies against glycolytic enzymes. The cell envelope is of archaeal origin and the glycolytic enzymes are cytosolic. This is opposed to the mitochondrial oxidative phosphorylation scheme which is rickettsial in origin. The primitive parts of the brain the cerebellum functions as an archaeal colony network and promotes the Warburg phenotype and glycolysis. The cerebellar brain is dominant in Neanderthals. The HLA genes are neanderthalic in origin and modulate lymphocytic function. The lymphocytes depend on glycolysis for its energy needs. The neocortex functions as a retroviral colony and promotes mitochondrial oxidative phosphorylation. The HERV genes functions as jumping genes and they can jump and insert themselves in between glycolytic enzyme genetic sequences producing mutations and mutated glycolytic enzymes. The glycolytic pathway becomes dysfunctional. Antibodies are formed against the mutated glycolytic proteins. Thus glycolysis and energy metabolism comes to a halt due to the inhibitory effect of the selfish HERV genes which needs mitochondrial function and ROS generation for its replicatory function and communicating with the cell. The Warburg phenotype results in conversion of the somatic cell to a stem cell phenotype. The Warburg phenotype and increased glycolysis and stem cell transformation results in civilisational disease. Disorders like autoimmune disease, schizophrenia, autism, cancer, degeneration and metabolic syndrome x are examples of global warming induced glycolytic disease.
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Experts in Neurology, Psychiatry, Internal Medicine