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Global Warming Related Epidemic Systemic Glycolytic Disease
Ravikumar Kurup,  Parameswara Achutha Kurup
ISBN: 978-1-941926-68-0
6.3 x 9.1 inches, 154pp, Paperback: $80
Published Date: July, 2016
To order hard copies, please contact book@openscienceonline.com
The Neanderthal metabolic patterns were different from the homo sapien patterns. Stress of the ice age led to the induction of heme oxygenase. Heme oxygenase converts heme to bilirubin and carbon monoxide. This results in heme depletion. Heme depletion induces ALA synthase and results in porphyrinogenesis. Porphyrin photooxidation results in ROS generation and induction of HIF alpha resulting in the Warburg phenotype with increased glycolysis, PDH inhibition and mitochondrial dysfunction. Heme depletion leads to defective function of the TCA cycle heme enzyme aconitase and the mitochondrial enzyme cytochrome C oxidase. This results in the body generating energy by glycolysis as well as membrane sodium potassium ATPase inhibition induced ATP synthesis. Mitochondrial dysfunction leads to insulin resistance. The global warming also produces oxidative stress and osmotic stress resulting in conversion of glucose to fructose. This results in increased fructose phosphorylation contributing to glycosaminoglycan synthesis, nucleic acid synthesis and lipogenesis. This contributes to a fat storage hibernatory syndrome which manifest as metabolic syndrome. The increased fructose phosphorylation and the cellular depletion of ATP can lead to cell death and neurodegeneration. Fructosylation of proteins leads to autoimmune disease with glycolytic enzymes as antigens. Fructose can affect brain derived neurotrophic growth factor function producing neuropsychiatric syndromes. This can be collectively called as global warming related glycolytic disease or Lemurian syndrome.
The Full Book PDF PDF
Front Matter PDF
Chapter 1 The Global Warming Related Glycolytic Disease PDF
Chapter 2 Endosymbiotic Actinidic Archaeal Mediated Warburg Phenotype Mediates Human Disease State PDF
Chapter 3 Endosymbiotic Actinidic Archaeal Cholesterol Catabolic Syndrome - Hypocholesterolemia and Human Diseases PDF
Chapter 4 Endosymbiotic Actinidic Archaeal Synthesis of Digoxin from Cholesterol Regulates Cellular Function and Contributes to Disease Pathology PDF
Chapter 5 Endosymbiotic Actinidic Archaeal Generation of Ammonia and Thiocyanate Regulates Cell/Neuro-Immuno-Endocrine System and Provides a Substrate for Archaeal Energetics PDF
Chapter 6 Endosymbiotic Actinidic Archaeal Digoxin Inhibited Sodium Potassium Atpase Mediated ATP Synthesis and Archaeal Ectoatpases Produce Neuro-Immuno-Metabolic-Endocrine/Cell Cycle Regulation PDF
Chapter 7 Endosymbiotic Actinidic Archaeal Synthesis of Pyruvate from Cholesterol and the GABA Shunt Pathway Regulates Cell Function PDF
Chapter 8 Endosymbiotic Actinidic Archaeal Synthesis of PAH from Cholesterol Regulates Cell Function - Relation to Global Warming PDF
Chapter 9 Endosymbiotic Actinidic Archaeal Synthesis of Short Chain Fatty Acid Butyrate and Propionate from Cholesterol Regulates Cellular Function PDF
Chapter 10 Endosymbiotic Actinidic Archaeal Synthesis of Bile Acids from Cholesterol Regulates Cellular Function PDF
Chapter 11 Endosymbiotic Actinidic Archaeal Synthesis of Neurotransmitters by Cholesterol Catabolism Regulates Brain Function PDF
Chapter 12 Archaeal Porphyrins, Regulation of Cell Function and Neuro-Immuno-Endocrine Integration PDF
Chapter 13 Endosymbiotic Actinidic Archaea and Viroidal Induced Warburg Phenotype Can Be Reversed by a Modified Vegetarian High Fiber, High Medium Chain Triglyceride Ketogenic Diet PDF
Back Matter PDF
Ravikumar Kurup
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Experts in Neurology, Psychiatry, Internal Medicine
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