Global warming leads to increase in endosymbiotic actinidic archaeal growth. Archaea are extremophiles. The actinidic archaea survive by catabolising cholesterol. The archaea and its antigens induce HIF alpha and activate the glycolytic pathway. The glycolytic pathway activation induces increased conversion of glucose to fructose by activation of the sorbitol pathway. Glucose is converted to sorbitol by the enzyme aldose reductase and sorbitol is converted to fructose by the action of sorbitol dehydrogenase. Fructose is phosphorylated by hexokinase or fructokinase to fructose phosphate. Hexokinase has a low km value for fructose and minimal amounts of fructose will be converted to fructose phosphate depleting the cellular ATP. ATP is converted to AMP and by the action of AMP deaminase is converted to uric acid. Thus there is resultant hyperuricemia and the depletion of ATP also produces membrane sodium potassium ATPase inhibition. Inhibition of membrane sodium potassium ATPase increases intracellular calcium and depletes magnesium. This produces cell death by opening up the mitochondrial PT pore, NFKB activation and immune activation, glutamate excitotoxicity and oncogene activation leading to systemic disorders. The depletion of ATP finally inhibits hexokinase as such and glucose phosphorylation stops blocking the glycolytic pathway and its coupling to the mitochondrial oxidative phosphorylation by the action of PT pore hexokinase. The cell is depleted of energy by glycolysis and the oxidative phosphorylation scheme and dies. Thus global warming via induction of glycolysis and Warburg phenotype and the increased conversion of glucose to fructose and the resultant cellular depletion of ATP can produce systemic disorders and cell dysfunction as well as death. This can produce the global warming related systemic syndrome.

Experts in Neurology, Psychiatry, Internal Medicine