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Archaea, Cerebellum and Human Systemic Disease
Ravikumar Kurup,  Parameswara Achutha Kurup
ISBN: 978-1-941926-60-4
6.3 x 9.1 inches, 72pp, Paperback: $65
Published Date: June, 2016
To order hard copies, please contact book@openscienceonline.com
Endosymbiotic neuronal archaea can produce cerebellar cognitive affective disorder. It can lead to an autonomic neuropathy with sympathetic overactivity and parasympathetic suppression. This leads to metabolic syndrome x, cancer, neurodegeneration, schizophrenia, autism and autoimmune disease. Archaea can synthesize porphyrins from cholesterol. The cholesterol ring is catabolized to pyruvate which then enters the GABA shunt pathway generating succinyl CoA and glycine the substrates for porphyrin synthesis. The increased amounts of porphyrins in the system leads to absorption of low level EMF leading to prefrontal cortex atrophy and cerebellar dominance. Cerebellar dominance leads to activation of sympathetic system and parasympathetic suppression. The archaea produces the Warburg phenotype by inducing HIF alpha. This results in inhibition of PDH resulting in defective formation of acetyl CoA and acetyl choline producing a parasympathetic neuropathy. The archaeal porphyrins can produce reactive oxygen species by photooxidation resulting in stress and sympathetic overactivity creating an excess of epinephrine, norepinephrine and dopamine. Stress and sympathetic overactivity as well as elevated cortisol can lead to beta amyloid accumulation. This can lead to neurodegeneration. Sympathetic overactivity can produce vasospasm leading onto coronary artery disease and stroke. Sympathetic overactivity and vagal block can produce defective insulin secretion and diabetes mellitus. This contributes to the genesis of metabolic syndrome x. Sympathetic overactivity and vagal block can produce immune activation and autoimmune disease. Immunity is regulated by a vagal reflex. Sympathetic overactivity and parasympathetic blockade can lead to cell proliferation and malignant transformation. Stress induced sympathetic overactivity and cholinergic underactivity can contribute to autism and schizophrenia. Thus an archaeal induced autonomic neuropathy with sympathetic overactivity and parasympathetic blockade can contribute to systemic disease. This results from the archaeal induced Warburg phenotype and PDH blockade resulting in defective acetyl CoA formation as well as increased prophyrinogenesis occurring via the GABA shunt pathway.
The Full Book PDF PDF
Front Matter PDF
Chapter 1 Porphyrions - Relation to CVS-pulmonary-Git Dysautonomia, Coronary/Cerebral Microangiopathy, Polyendocrine Failure and Chronic Fatigue/Panic Syndrome Complex PDF
Chapter 2 Neanderthal Hybrids and Dysautonomic Syndrome PDF
Chapter 3 Endosymbiotic Actinidic Archaeal Mediated Warburg Phenotype Mediates Human Disease State PDF
Back Matter PDF
Ravikumar Kurup
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Experts in Neurology, Psychiatry, Philosophy
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