Global warming also as described leads to increase in endosymbiotic actinidic archaeal growth. Archaea are extremophiles. The actinidic archaea survive by catabolising cholesterol. The archaea and its antigens induce HIF alpha and activate the glycolytic pathway. The glycolytic pathway activation induces increased conversion of glucose to fructose by activation of the sorbitol pathway. Glucose is converted to sorbitol by the enzyme aldose reductase and sorbitol is converted to fructose by the action of sorbitol dehydrogenase. Fructose is phosphorylated by hexokinase or fructokinase to fructose phosphate. Hexokinase has a low km value for fructose and minimal amounts of fructose will be converted to fructose phosphate depleting the cellular ATP. ATP is converted to AMP and by the action of AMP deaminase is converted to uric acid. Thus there is resultant hyperuricemia and the depletion of ATP also produces membrane sodium potassium ATPase inhibition. Inhibition of membrane sodium potassium ATPase increases intracellular calcium and depletes magnesium. This produces cell death by opening up the mitochondrial PT pore, NFKB activation and immune activation, glutamate excitotoxicity and oncogene activation leading to systemic disorders. The depletion of ATP finally inhibits hexokinase as such and glucose phosphorylation stops blocking the glycolytic pathway and its coupling to the mitochondrial oxidative phosphorylation by the action of PT pore hexokinase. The cell is depleted of energy by glycolysis and the oxidative phosphorylation scheme and dies. Thus global warming via induction of glycolysis and Warburg phenotype and the increased conversion of glucose to fructose and the resultant cellular depletion of ATP can produce systemic disorders and cell dysfunction as well as death. This can produce the global warming related renal, pulmonary, gastrointestinal, hepatic, endocrine and cardiovascular syndromes. This can lead to interstial lung disease, chronic obstructive pulmonary disease, coronary artery disease, cerebrovascular accidents, type 2 diabetes mellitus, chronic renal failure, cirrhosis liver, inflammatory bowel disease, degenerative joint disease, cancer syndromes, neurodegenerations, autoimmune diseases and neuropsychiatric diseases. These diseases have an increased incidence in recent epidemiological studies.
Dr. Ravikumar Kurup trained in Internal Medicine, Neurology and Metabolic Medicine at Medical College, Trivandrum and Christian Medical College, Vellore. He holds a doctorate degree in Internal Medicine and Neurology. He is a member of the National Academy of Medical Sciences, India. He works as Professor of Metabolic Medicine and Metabolic Neurology at Metabolic Disorders Research Center, Trivandrum. He also works as Professor of Internal Medicine and Head of the divisions of Metabolic Medicine and Hematology at Medical College Hospital, Trivandrum. His areas of research interests are in Neurochemistry and Metabolic Medicine.
Parameswara Achutha Kurup
The Metabolic Disorders Research Centre, TC 4/1525, Gouri Sadan, Kattu Road North of Cliff House, Kowdiar PO Trivandrum, Kerala, India.
Experts in Neurology, Psychiatry, Philosophy