Climate change and related stress leads to increased porphyrin synthesis leading on to the generation of porphyrions. Climatic changes of global warming and ice age can induce heme oxygenase which depletes heme inducing porphyrin synthesis. Defect in heme synthesis and heme depletion leads to deficiency of heme enzymes. Deficiency cytochrome C oxidase and aconitase leads to mitochondrial oxidative phosphorylation defects and TCA cycle defects. There is increase in glycolysis consequent to porphyrin photo-oxidation induced free radical generation and HIF alpha induction. This produces the Warburg phenotype. Deficiency of acetyl CoA leads to defects in the isoprenoid pathway and defective synthesis of cholesterol and ubiquinone. The porphyrins can have quantal perception of low level EMF fields leading to prefrontal cortex atrophy and cerebellar dominance. This leads onto Neanderthalisation of the brain and schizophrenia and autism. The mitochondrial dysfunction leads onto insulin resistance and metabolic syndrome x as well as neurodegeneration. The Warburg phenotype and increased glycolysis leads to oncogenesis. The increase in lymphocyte glycolysis can produce immune activation and autoimmune disease. Thus the stress induced porphyria due to climatic change and environmental pollution can lead to civilizational disease.

Experts in Neurology, Psychiatry, Medicine, Evolutionary Biology, Neuro-philosophy, Psychology