Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Evaluation of Some Biochemical Parameters of Plasmodium falciparum Infected Inhabitants of Ekpoma Metropolis, Nigeria
Current Issue
Volume 3, 2018
Issue 1 (January)
Pages: 1-7   |   Vol. 3, No. 1, January 2018   |   Follow on         
Paper in PDF Downloads: 53   Since Jan. 15, 2018 Views: 862   Since Jan. 15, 2018
Authors
[1]
Dic-Ijiewere O. Ebenezer, Department of Chemical Pathology, Faculty of Clinical Sciences, Ambrose Alli University, Ekpoma, Nigeria.
Abstract
This study was carried out to determine the impact of malaria parasite infection caused by Plasmodium falciparum on some biochemical parameters. One hundred and five (105) malaria parasite positive male and female subjects and fifty (50) apparently healthy subjects were recruited for this study. Malaria Parasite diagnosis was done by Microscopic Examination of Thick and Thin Stained Blood Films. Age range 15-25 had the highest prevalent rate of 17.14% for males and 14.29% for females while the age range 55-60 had the least prevalent rate of 0.95% for both male and female. when control values were compared with the mean values obtained from the biochemical analysis of Plasmodium falciparum parasitaemia subject samples, it was significantly lower for glucose (p=0.04), ALT (p=0.00), AST (p=0.00), ALP (p=0.00), total protein (p=0.01), Globulin (p=0.02) and Creatinine (p=0.04). Total cholesterol (p=0.12), Triglyceride (p=0.06), Albumin (p=0.49) and Urea (p=0.15) were statistically not significant for malaria parasitaemia subject samples. Glucose, Total cholesterol, Liver enzymes, creatinine changes were seen involved in malaria infection caused by Plasmodium falciparum. The prevention of malarial infection is still the most valid method of preventing these conditions and early diagnosis and treatment are the measures likely to decrease malarial complications commonly determined by changes in these biochemical parameters.
Keywords
Malaria, Parasitaemia, Biochemical Profile, Infected, P. falciparum
Reference
[1]
Singh, B., Kim Sung and Matusop. A., (2004): A large focus of naturally acquired plasmodium Knowlesi; Infectious in human beings. Lancet. 363 (9414): 1017-1024.
[2]
Mueller, I., Zimmerman, P. A., and Reeder, J. C., (2007): Plasmodium malaria and plasmodium ovale in the “bashful” malaria parasitis Trends Parasitol 23 (6): 278-283.
[3]
Prothero, R. Mansell E., (1999): Malaria forest and people in southeast Asia-Singarpore. Journal of Tropical Geography. 20 (1); 76-85.
[4]
Lindemann, M. (1999): Medicine and society in early modern Europe. Cambridge University Press. Pp 62.
[5]
Gratz, N. G., (2006): The vector and rodent borne diseases of Europe and North America. Their distribution and public health burden. Cambridge University Press. Hppt://books.google.com/books.
[6]
WHO (2008): Severe plasmodium falciparium malaria; Trans. Royal Soc. Trop. Med. Hug. 95; 51-59.
[7]
Bledsoe, G. H., (2005): Malaria for clinicians in the United State. South Med. J. 98 (12); 1197-1204.
[8]
Sturn, A., Amino, R., Van de Sand, C., Regen, T., Retzlaff, S., Rennenberg, A., Krueger A., Pollok, J. M., Menard, R., and Heussler, V. T., (2006): Manipulation of host hepatocytes by the malaria for delivery into liver sinusoids. Science. 313 (5791); 1287-1290.
[9]
Cogswell, F. B., (1992): The hypnozoite and relapse in primate malaria. CliniMicrobio. Rev. 5 (1); 26-35.
[10]
Angus MGN, Fletcher KA, Maegraith BG. Studies on the lipids of Plasmodium knowlesi infected rhesus monkeys (Macacamulatta). IV. Changes in erythrocyte lipids. Ann Trop Med Parasitol. 1971; 12: 429-439.
[11]
Angus MGN, Fletcher KA, Maegraith BG. Studies on the lipids of Plasmodium knowlesi infected rhesus monkeys (Macacamulatta). II. Changes in serum nonesterified fatty acids. Ann Trop Med Parasitol. 1971; 12: 155-167.
[12]
Chagnon A, Guiguen Y, Sutre E. Hypocholesterolemia in malaria: an aid to diagnosis? Semaine des Hopitaux. 1985; 12: 2075-2076.
[13]
National Population Commission (2006): Housing and population census result: Edo State National population Office, Benin City.
[14]
NIPOST (2009): Post Offices-with map of LGA. Archived from the original on 2009-10-07. Retrieved 2009-10-20.
[15]
Dayachi, F., Kabongo, L. and Ngoie, K. (1991): Decreased mortality from Malaria in children with symptomatic HIV infection. Int. Cont. AIDS. 2: 164.
[16]
Monica Cheesbrough. (2005). Discrete Laboratory Practice in Tropical Countries Part 1, Cambridge Second Editions. Published by Press Syndicate of the University of Cambridge, chp. 5, page 247-258.
[17]
Warhurst, D. C. and Williams, J. E. (1996): Acp Broadsheet no 148. July 1996. Laboratory diagnosis of malaria. J. Clin. Pathol. 49: 533-538.
[18]
Reitman, S. and Frankel, S. (1957): A colorimetric method for the determination of Aspartate amino transferase and Alanine amino transferase activities in serum. Amer. J Clin Path; 28: 56.
[19]
Rec. Gscc (DGKC) (1972). Optimised Standard Colorimetric Methods. J. Clin. Chem. Clin. Biochem., 10: 182.
[20]
Spencer, K. and Price, C. P. (1977). Simple screening tests for serum albumin levels. Annals of Clinical Biochemistry, 14: 105-115.
[21]
Slot, C. (1965). Blood creatinine level an renal function. Journal of Clinical Laboratory Investigation. 17: 891-895.
[22]
Kaplan, A. (1965). Standard Methods of Clinical Chemistry. New York, Academic Press pp. 256.
[23]
Rey and Wielinger (1970). Glucose oxidase method. Z. analyt. chem. 252: 224.
[24]
Allain, C. C., Poon, L. S., Chan, C. S. G. (1974): Enzymatic determination of total serum cholesterol. Clinical Chemistry. 20, 470.
[25]
Mbanugo, J. I. and Ejims, D. O. (2000). Plasmodium Infections in Children Aged 0-5 yrs in Awka Metropolis, Anambra State, Nigeria. Nigeria Journal of Parasitology. 2: 55-59.
[26]
Uzoegwu, P. N. and Onwurah, A. E. (2003). correlation of lipid Peroxide in malariapositive and negative status of AA, AS and SS individuals from the University of Nigeria Nsukka community. Journal of Bio Research and Biotechnology, 1 (1): 97-114.
[27]
Nwaorgu, O. C. and Orajaka, B. N. (2011). Prevalence of malaria among Children 1-10 years old in Communities in Awka North Local Government Area, Anambra State South East Nigeria. International Multidisciplinary Journal Ethiopia, 5 (5): 264-281.
[28]
Okafor, F. U. and Oko-Ose, J. N. (2012). Prevalence of malaria infections among children aged six months to eleven years (6 months-11 years) in a tertiary institution in Benin City, Nigeria. Global Advanced Journal and Medical Sciences, 1 (10): 273-279.
[29]
Aribodor, D. N., Njoku, O. O., Eneanya, C. I. and Onyali, I. O. (2003). Studies on Prevalence of Malaria and management practices of the Azia Community in Ihiala L. G. A., Anambra State, South-East Nigeria. Nigeria Journal of Parasitology, 22: 42-48.
[30]
Goodyer, I. D., Taraschi, T. F. (1997). Plasmodium falciparum: a simple, rapid method for detecting parasite clones in microtiter plates. Exp. Parasitol., 86: 158-160.
[31]
Davis, T. M., Binh, T. Q., Thu le, T. A., Long, T. T., Johnston, W., Robertson, K. and Barrett, P. H. (2002). Glucose and lactate turnover in adults with falciparum malaria: effect of complications and antimalarial therapy. Trans. R. Soc. Trop. Med. Hyg. 96: 411-417.
[32]
Binh, T. Q., Davis, T. M., Johnston, W., Thu, L. T., Boston, R., Danh, P. T. and Anh, T. K. (1997). Glucose metabolism in severe malaria: minimal model analysis of the intravenous glucose tolerance test incorporating a stable glucose label. Metabolism. 46 (12): 1435-1440.
[33]
Esan, A. J. (2016): Incidence and Evaluation of Stress Induced In Plasmodium Falciparum Malaria Infected Individuals Using Cortisol, Malondialdehyde, Blood Glucose and Lipid Profile Level. Journal of Medical and Biological Science Research Vol. 2 (10), pp. 158-162, December, 2016 ISSN: 2449-1810.
[34]
Benjamin J. Visser, Rosanne W. Wieten, Ingeborg M. Nagel, and Martin P. Grobusc (2013): Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis. Malar J. 12: 442.
[35]
Memon, R. A., Staprans, I., Noor, M., Holleran, W. M., Uchida, Y., Moser, A. H., Feingold, K. R., Grunfeld, C. (2000). Infection and inflammation induce LDL oxidation in vivo. Arterioscler. Thromb. Vasc. Biol. 20: 1536-1542.
[36]
Ignatius, C. M., Emeka, E. N. and Blessing, N. E. (2008): “Effect of malaria parasitaemia on liver enzyme tests,” International Journal of Tropical Medicine, vol. 3, no. 3, pp. 49-52.
[37]
Onyesom, I. and Onyemakonor, N. (2011): “Levels of parasitaemia and changes in some liver enzymes among malarial infected patients in Edo-Delta Region of Nigeria,” Current Research Journal of Biological Sciences, vol. 3, no. 2, pp. 78-81.
[38]
Mohamed Al-Salahy, Bushra Shnawa, GamalAbed, Ahmed Mandour, and Ali Al-Ezzi. (2016): Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen. Interdisciplinary Perspectives on Infectious Diseases; Volume 2016, Article ID 5954394, 5 pages.
[39]
Melita, K. S., Halankar, A. R., Makwana, P. D., Torane, P. P., Satija, P. S. and Shah, V. B. (2001). Severe acute renal failure in Malaria. Journal of Postgraduate Medicine, 47 (1): 24-26.
[40]
Parkash, J., Singh, A. K., Kumar, N. S. and Saxene, R. K. (2003). Acute renal failure in Plasmodium vivax malaria. Journal of Association of Physicians, India. 51: 265-267.
[41]
Ogbadoyi, E. O and Tsado, R. D. (2009). Renal and Hepatic Dysfunction in Malaria patients in Minna, North Central Nigeria. Online Journal of Health and Allied Sciences, 8 (3): 3-8.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
CONTACT US
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
E-mail:
LET'S GET IN TOUCH
Name
E-mail
Subject
Message
SEND MASSAGE
Copyright © 2013-, Open Science Publishers - All Rights Reserved