Present study was taken up to develop scaffolds from biodegradable polymeric system and also to develop a new and simple method for preparation of scaffold. Number of drug delivery systems are available today but there is no ideal drug delivery system which full-fill all requirements. Hence scaffold is ideal drug delivery system which gives more advantages over conventional drug delivery systems. Scaffolds loaded with Meloxicam were prepared by using quasi emulsion solvent diffusion method using Polylactic co-glycolic acid (PLGA) and Polylactic acid (PLA) biodegradable polymer which is non toxic in nature. The synthesized scaffolds we reanalyzed for particle size, production yield, entrapment efficiency, zeta potential, Fourier transform infrared spectroscopy (FT-IR), Scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Brunauer-Emmett-Teller (BET) analysis. The FT-IR spectroscopy shows characteristics peak for pure Meloxicam and scaffold. The SEM analysis confirms porous network of scaffold. Surface area of scaffold for drug entrapment was studied by BET analysis and shows the good surface area available for drug entrapment. Entrapment efficiency of scaffold was 91.15% and practical yield was 45.37%. The in-vitro dissolution study for scaffold shows high drug release up to 90%cumulative drug release (CDR) than pure drug which show upto 50% CDR after 6 hrs thus it shows that increased in solubility and dissolution of pure Meloxicam entrapped in scaffold.

Scaffold, Tissue Engineering, Drug Delivery System, Meloxicam