Antimutagenicity of the Water Extracts, Radical Scavenging Activity, and Phenolic Acids in the Tops of Diverse Ipomoea batatas (L.) Lam
[1]
Shahidul Islam, Department of Agriculture, University of Arkansas-Pine Bluff, Pine Bluff, USA.
Radical scavenging activity (RSA) and antimutagenicity of the water extracts were investigated using diverse sweetpotatoes [Ipomoea batatas (L.) Lam] accessions. The results revealed that RSA is depended on their respective polyphenol content of sweetpotato leaves. The extract from the enhanced polyphenol contents accessions successfully diminished the reverse mutation induced not only by Trp-P-1 and Trp-P-2, IQ, B(a) P, and 4-NQO but also by dimethyl sulphoxide extract of grilled beef. Comparison of the inhibitory activity of the extracts from the medium and low polyphenol accumulator genotypes suggested that the polyphenol content in the leaves decreases the mutagenic activity of the mutagens as heterocyclic amines. Three constituents of leaves polyphenols, 4,5 di-CQA (caffeoylquinic acid) and 3,4,5-tri-CQA, effectively inhibited the reverse mutation induced by Trp-P-1, Trp-P-2, and IQ. The physiological function of caffeoylquinic acid (CQA) derivatives with plural caffeoyl group are more effective than with a monocaffeoyl one. Furthermore, determination of the inhibitory activity of sectional portions using the samples A-35, A-09, and A-28 were demonstrated that the inhibitory components are abundant in the leaves, suggesting the involvement of phenolics in the antimutagenicity of the extract from the sweetpotato tops. This result may be useful for various chemical breeding programs to improve desirable organoleptic and nutritional quality characteristics and health benefits of peoples.
Antimutagenicity, Radical Scavenging Activity, Phenolics, Caffeic Acids, Sweetpotato
[1]
Food and Agriculture Organization (FAO). (1997). FAO production yearbook. FAO (United Nations), Rome, Italy, 1997. Vol. 51
[2]
Hoff, J. E.; Howe, J. M.; Mitchell, C. A. (1982). Nutritional and cultural aspects of plant species selection for a controlled ecological life support system. NASA Contractor Rep. 166324, Moffett Field, CA.
[3]
Ames BN, McCann J., Yamasaki E. (1975). Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 31: 347-364.
[4]
Islam, S. (2006). Sweetpotato (Ipomoea batatas L.) Leaf: Its Potential Effect on Human Health and Nutrition. Journal of Food Science, 71: R13-R21.
[5]
Islam, S. (2008). “Potential Chemo-preventative properties isolated from Ipomoea batatas leaves.” pp. 96-109. In: Functional Foods and Chronic Diseases. ISBN 978-0976753544. Publisher: Functional Food Center at D & A Inc., TX, USA.
[6]
Islam, S. (2009). Polyphenol contents and caffeic acid derivatives from leaves of Ipomoea batatas genotypes. Acta Horticulture, vol. 841: 527-530.
[7]
Islam, S. (2014). Medicinal and Nutritional Qualities of Sweetpotato Tips and Leave. It is published by Cooperative Extension Service. FSA6135. p. 1-4.
[8]
Islam, I., Shaikh, A. and Islam, S. (2009). Antimutagenic and antioxidative potential phytochemicals from sweetpotato. International J. Cancer Research. 5: 83-94.
[9]
Nagao, M., Honda, M., Seino, Y., Yahagi, T. and Sugimura, T. (1977). Mutagenicities of smoke condensates and the charred surface of fish and meat. Cancer Lett., 2: 221-227.
[10]
Kasai, H., Nishimura, S., Wakabayashi, K., Nagao, M., and Sugimura, T. (1980). Chemical synthesis of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ), a potent mutagen isolated from broiled fish. Proc. Japan Acad., 56: 382-384.
[11]
Yamaizumi, Z., Shimoi, T., Kasai, H., Nishimura, S., Takahashi, Y., Nagao, M. and Sugimura, T. (1980). Detection of potent mutagens, Trp-P-1 and Trp-P-2, in broiled fish. Cancer Lett., 9: 75-83.
[12]
Shinohara K, Kurogi M, Miwa M, Kong, Z, Hosoda H. (1988). Antimutagenicity of dialyzates of vegetables and fruits. Agric Biol Chem. 52: 1369-1375.
[13]
Villareal RL, Tsou SC, Lo HF, Chiu SC. (1982). Sweetpotato tips as vegetables. In: Villareal RL, Griggs TD, editors. SweetPotato. Proceedings of the First International Symposium, AVRDC, Shanhua, Taiwan. P. 313-320.
[14]
Woolfe JA. (1992). Sweetpotato. An untapped food resource. Cambridge, U. K.: Cambridge University Press. P. 118-187.
[15]
Yoshimoto M. (2001). New trends of processing and use of sweetpotato in Japan. Farming Japan 35: 22-28.
[16]
Islam, S. and M. Jalaluddin. (2004). Sweetpotato- a potential nutritionally rich multifunctional food crop for Arkansas: J. Arkansas Agricultural & Rural Dev, 4: 3-7.
[17]
Mahmood, N., Moore, S., Tommasi, D., Simone, D., Colman S., Hay J., Pizza C. (1993). Inhibition of HIV infection by caffeoylquinic acid derivatives. Antiviral Chem Chemother 4: 235-240.
[18]
Kimura Y, Okuda H, Okuda T, Hatano T, Agata I, Arichi S. (1985). Studies on the activities of tannins and related compounds from medicinal plants and drugs. VI. Inhibitory effects of caffeoylquinic acids on histamine release from rat peritoneal mast cells. Chem Pharm Bull 1985: 690-696.
[19]
Murayama T, Yada H, Kobori M, Shinmoto H, Tsushida T. (2002). Evaluation of three antioxidants and their identification and radical scavenging activity in edible chrysanthemums. J Japan Soc Hort Sci 72: 236-242.
[20]
Son S, Lewis, BA. (2002). Free radical scavenging and antioxidative activity of caffeic amide and ester analogues: structure-activity relationship. J Agric Food Chem 50: 468-472.
[21]
Islam Md S, Yoshimoto M, Yahara S, Okuno S, Ishiguro K, Yamakawa O. (2002). Identification and characterization of foliar polyphenolic composition in sweetpotato (Ipomoea batatas L.) genotypes. J Agric Food Chem 50: 3718-3722.
[22]
Brand-Williams, W., M. E. Cuvelier, and C. Berset. (1995). Use of a free radical method to evaluate antioxidant activity. Lebensm. Wiss. Technol., 28: 25-30.
[23]
Islam, S. Yoshimoto, Yamakawa, (2003). Distribution and physiological function of caffeoylquinic acid derivatives in sweetpotato genotypes. Journal of Food Science, 68: 111-118.
[24]
Islam, S., Yoshimoto, Ishiguro, K. and Yamakawa, O. (2003). Bioactive and Functional properties of Ipomoea Batatas L. Leaves. Acta Horticulturae, 628: 693-699.
[25]
Walter WM, Purcell AE, McCollum GK. (1979). Use of high-pressure liquid chromatography for analysis of sweetpotato phenolics. J Agric Food Chem 27: 938-941.
[26]
Lugasi, A., D. P. E. Almedia, and E. Dworschak. (1999). Chlorogenic acid content and antioxidant properties of potato tubers as related to nitrogen fertilization. Acta Alimentaria, 28: 183-195.
[27]
Kwon, H. C., Jung, C. M., Shin C. G., Lee, J. K., Choi, S. U., Kim, S. Y. and Lee, K. R. (2000). A new caffeoylquinic acid from Aster scaber and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. Chem. Pharm. Bull., 48: 1796-1798.
[28]
Yagasaki K, Miura Y, Okauchi R, Furuse T. (2000). Inhibitory effects of chlorogenic acid and its related compounds on the invasion of hepatoma cells in culture. Cytotechnol 33: 229-235.
[29]
Shimozono H, Kobori M, Shinmoto H, Tsushida T. (1996). Suppression of the melanogenesis of mouse melanoma B 16 cells by the sweetpotato extract. Nippon Shokuhin Kagaku Kogaku Kaishi 43: 313-317.
[30]
Peluso G, Feo VD, Simone FD, Bresciano E, Vuotto ML. (1995). Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide anion production. J Nat Prod 58: 639-646.
[31]
Islam, S. (2016). Some bioactive constituents, antioxidant, and antimutagenic activities in the Leaves of Ipomoea batatas Lam. Genotypes. American Journal of Food Science & Technology, 4 (3): 70-80.
