Antimutagenicity of the Water Extracts, Radical Scavenging Activity, and Phenolic Acids in the Tops of Diverse Ipomoea batatas (L.) Lam
Radical scavenging activity (RSA) and antimutagenicity of the water extracts were investigated using diverse sweetpotatoes [Ipomoea batatas (L.) Lam] accessions. The results revealed that RSA is depended on their respective polyphenol content of sweetpotato leaves. The extract from the enhanced polyphenol contents accessions successfully diminished the reverse mutation induced not only by Trp-P-1 and Trp-P-2, IQ, B(a) P, and 4-NQO but also by dimethyl sulphoxide extract of grilled beef. Comparison of the inhibitory activity of the extracts from the medium and low polyphenol accumulator genotypes suggested that the polyphenol content in the leaves decreases the mutagenic activity of the mutagens as heterocyclic amines. Three constituents of leaves polyphenols, 4,5 di-CQA (caffeoylquinic acid) and 3,4,5-tri-CQA, effectively inhibited the reverse mutation induced by Trp-P-1, Trp-P-2, and IQ. The physiological function of caffeoylquinic acid (CQA) derivatives with plural caffeoyl group are more effective than with a monocaffeoyl one. Furthermore, determination of the inhibitory activity of sectional portions using the samples A-35, A-09, and A-28 were demonstrated that the inhibitory components are abundant in the leaves, suggesting the involvement of phenolics in the antimutagenicity of the extract from the sweetpotato tops. This result may be useful for various chemical breeding programs to improve desirable organoleptic and nutritional quality characteristics and health benefits of peoples.
Antimutagenicity, Radical Scavenging Activity, Phenolics, Caffeic Acids, Sweetpotato
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