Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Relationship Between Inflammatory Markers and Muscular Parameters Used in the Nutritional Evaluation of Renal Patients in Hemodialysis
Current Issue
Volume 3, 2018
Issue 5 (September)
Pages: 64-71   |   Vol. 3, No. 5, September 2018   |   Follow on         
Paper in PDF Downloads: 42   Since Sep. 13, 2018 Views: 1212   Since Sep. 13, 2018
Authors
[1]
Cristiane Maria de Oliveira, Department of Nutrition, Potiguar University, Natal, Brazil.
[2]
Angélica Quirino da Costa, Department of Nutrition, Potiguar University, Natal, Brazil.
[3]
Juliany Caroline Silva de Sousa, Department of Nutrition, Potiguar University, Natal, Brazil.
[4]
Raphael Paschoal Serquiz, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil.
[5]
Fabiana Maria Coimbra de Carvalho, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil.
[6]
Ana Heloneida de Araújo Morais, Department of Nutrition and Biochemistry, Federal University of Rio Grande do Norte, Natal, Brazil.
[7]
Alexandre Coelho Serquiz, Department of Nutrition, University Center of Rio Grande do Norte, Natal, Brazil.
Abstract
Chronic Kidney Disease (CKD) is a manifestation that can lead to accumulation of toxins in the blood. Inflammation is a physiological process due to the different stimuli generated, as well as the dialysis process. The present research aims to associate these factors with the waist circumference (WC), the arm perimeter (AP), the Hand Grip Strength (HGS) and the adductor thumb muscle (ATM), used in the nutritional assessment of patients on hemodialysis treatment. Methods: 34 patients on dialysis with age ranging from 20 to 78 years were selected. The mean performance was calculated based on the mean and standard deviation, for all the variables, and for the degree of association between pairs of variables the Sperman correlation test was used. The significance level was set at 5% (p <0.05). There was correlation between inflammatory markers and the WC. The BMI was used to classify the patients into the nutritional states of malnutrition and eutrophy. The AP was related to the HGS and ATM, and was associated with the imminence of inflammation for the patients. This study presents an evaluation on the WC and the HGS as contributing to the control of such inflammatory processes. What is laid bare herein is not only the issue of lean mass loss, but also one of the most frequent problems afflicting patients with CKD in HD, the increase of WP, a much discussed issue, which plays an important role in the pulmonary state, favoring complications in CKD patients.
Keywords
Renal Disease, Hemodialysis, Inflammation, Nutritional Evaluation
Reference
[1]
Webster AC, Nagler EV, Morton RL, Masson P. (2017). Chronic Kidney Disease. Lancet. 2017; 389 (10075): 1238-1252.
[2]
Kaysen GA. (2014). Progressive inflammation and wasting in patients with ESRD. Clin J Am Soc Nephrol. 2014; 9: 225–226.
[3]
Liu BC, Tang TT, Lv LL, Lan HY. Renal tubule injury: a driving force toward chronic kidney disease. Kidney Int. 2018; 93 (3): 568-579.
[4]
Haddad F, Zaldivar F, Cooper DM, Adams GR. (2005). IL-6-induced skeletal muscle atrophy. J Appl Physiol. 2005; 98: 911–917.
[5]
Zhang L, Rajan V, Lin E, et al. (2011). Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. Faseb J. 2011; 25: 1653–1663.
[6]
Flores-García AL, Sánchez-Ramírez CA, Newton-Sánchez AO, Rojas-Larios F. (2018). Correlation between skinfold thickness and bioelectrical impedance analysis for the evaluation of body composition in patients on dialysis. Nutr Hosp. 2018; 35: 117-122.
[7]
Pereira RA, Cordeiro AC, Avesani CM, et al. Sarcopenia in chronic kidney disease on conservative therapy: prevalence and association with mortality. Nephrol Dial Transplant. 2015; 30 (10): 1718-1725.
[8]
Bohannon RW, Peolsson A, Massy-Westropp N, Desrosiers J, Bear-Lehman J. (2006). Reference values for adult grip strength measured with a Jamar dynamometer: a descriptive meta-analysis. Physiotherapy. 2006; 92 (1): 11-15.
[9]
Oliveira CMC, Kubrusly M, Mota RS, Choukroun G, Neto JB, Silva CAB (2012). Adductor Pollicis Muscle Thickness: A Promising Anthropometric Parameter for Patients With Chronic Renal Failure. J Ren Nutr. 2012; 22 (3): 307-316.
[10]
Kalantar-Zadeh K, Abbott KC, Salahudeen AK, Kilpatrick RD, Horxich TB. (2005). Survival advantages of obesity in dialysis patients. Am J Clin Nutr 2005; 81: 543-54.
[11]
Roubenoff R. (2004). Sarcopenic obesity: The confluence of two epidemics. Obes Res. 2004; 12 (6): 887-888.
[12]
Axelsson J, Rashid Qureshi A, Suliman ME, et al. (2004). Truncal fat mass as a contributor to inflammation in end-stage renal disease. Am J Clin Nutr. 2004; 80 (5): 1222–1229.
[13]
Lipschitz DA. (1994). Screening for nutritional status in the elderly. Prim Care. 1994; 21 (1): 55-67.
[14]
Frisancho AR. (1974). Triceps skinfold and upper arm muscle size norms for assessment of nutritional status. Am J Clin Nutr. 1974; 27: 1052-1057.
[15]
Lohman TG, Roche AF, Martorell R (1998). Anthropometric Standardization Reference Manual. Champaign, Illinois: Human Kinetics, 1988.
[16]
National Health and Nutrition Examination Survey (NHANES). (2007). Anthropometry Procedures Manual. United States (U.S), 2007.
[17]
Frisancho, AR. (1939). Anthropometric standards for the assessment of growth and nutritional status. United States (U.S): Ann Arbor; 1939.
[18]
World Health Organization. (1998). Obesity: preventing and managing the global epidemic. WHO Technical Report Series. Geneva, 1998.
[19]
Lameu EB, Gerude MF, Corrêa RC, Lima KA. (2004). Adductor pollicis muscle: a new anthropometric parameter. Rev Hosp Clin Fac Med. São Paulo. 2004; 59 (2): 57-62.
[20]
Oliveira CMC, Kubrusly M, Mota RS, Choukroun G, Neto JB, Silva CAB. (2012). Adductor Pollicis Muscle Thickness: A Promising Anthropometric Parameter for Patients With Chronic Renal Failure. J Nutr Ren. 2012; 22 (3): 307-316.
[21]
Moreira AC, Carolino E, Domingos F, Gaspar A, Ponce P, Camilo MC. (2013). Nutritional status influences generic and disease-specific quality of life measures in hemodialysis patients. Nutr. Hosp. 2013; 28 (3): 951-957.
[22]
Bohannon RW, Peolsson A, Massy-Westropp N, Desrosiers J, Bear-Lehman J. (2006). Reference values for adult grip strength measured with a Jamar dynamometer: a descriptive meta-analysis. Physiotherapy. 2006; 92 (1): 11-15.
[23]
Jaqueto, Marcel, Delfino VDA, Bortolasci CC, et al. (2016). Are PTH levels related to oxidative stress and inflammation in chronic kidney disease patients on hemodialysis? J Bras Nefrol. 2016; 38 (3): 288-295.
[24]
Himmelfarb J, Hakim RM. (2003) Oxidative stress in uremia. Curr Opin Nephrol Hypertens. 2003; 12 (6): 593-598.
[25]
Amer P. (2003). The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trend Endocrinol Metab. 2003; 14: 137-145.
[26]
Fried SK, Bunkin DA, Greenberg AS. (1998). Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J clin Endocrinol Metab. 1998; 83 (3): 897-850.
[27]
Postorino M, Marino C, Tripepi G, Zoccali C, Group CW. (2009). Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol. 2009; 53 (15): 1265–1272.
[28]
Atzmon G, Yang XM, Muzumdar R, et al. (2002). Differential gene expression between visceral and subcutaneous fat depots. Horm Metab Res. 2002; 34: 622-628.
[29]
Saldanha JF, Carrero JJ, Mafra D. (2011). The possible role of nesfatin-1 on appetite regulation in hemodialysis patients. Med Hypotheses. 2011; 77 (4): 654-657.
[30]
Hung-yuan C, Yen-Ling C, Yi-Fang C, Shih-Ping H, Mei-Fen P, Ju-Yeh Y, et al. (2014). Visceral adiposity index and risks of cardiovascular events and mortality in prevalent hemodialysis patients. Cardiovasc. Diabetol. 2014; 136 (13): 1-9.
[31]
Spittle M, Hoenich NA, Handelman G, Adhikarla R, Homel P, Levin NW. (2002). Oxidative Stress and Inflammation in Hemodialysis Patients. Am J Kidney Dis. 2002; 39 (2): 444.
[32]
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. (2000). Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?. Atherosclerosis. 2000; 148 (2): 209-214.
[33]
Himmelfarb J, Hakim RM. (2003). Oxidative stress in uremia. Curr Opin Nephrol Hypertens. 2003; 12 (6): 593-598.
[34]
Kershaw EE, Flier JS. (2004). Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004; 89: 2548-2556.
[35]
Mohamed-Ali V, Goodrick S, Rawesh A, et al. (1997). Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab. 1997; 82 (12): 2548-2556.
[36]
. Pigott R, Dillon P, Hemingway IH, Gearing AJ. (1992). Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochen Biophys Res Commun. 1992; 187: 584-589.
[37]
Cheung, CC, Nguyen US, Au E, Tan KC, Kung AW. (2013). Association of handgrip strength with chronic diseases and multimorbidity. Age (Dordr). 2013; 35 (3): 929-941.
[38]
Humphreys J, De la Maza P, Hirsch S, Barrera G, Gattas V, Bunout D. (2002). Muscle strength as a predictor of loss of functional status in hospitalized patients. Nutrition. 2002; 18: 616-20.
[39]
Pereira RA, Cordeiro AC, Avesani CM, et al. (2015). Sarcopenia in chronic kidney disease on conservative therapy: prevalence and association with mortality. Nephrol. Dial. Transplant. 2015; 30 (10): 1718-1725.
[40]
Bastard JP, Jardel C, Delattre J, Hainque B, Bruckert E, Oberlin F. (1999). Evidence for a link between adipose tissue interleukin-6 content and sérum C-reactive protein concentrations in obese subjects. Circulations. 1999, 99 (16): 2221-2222.
[41]
Williams B, Hattersley J, Layward E, et al. (1991). Metabolic acidosis and skeletal muscle adaptation to low protein diets in chronic uremia. Kidney Int. 1991, 40 (4): 779-786.
[42]
Reaich D, Channon SM, Scrimgeour CM, et al. (1993). Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol. 1993, 265 (2 Pt 1): E230-235.
[43]
Bossola M, Muscaritoli M, Costelli P. (2002). Muscle ubiquitin m-rNA levels in patients witch end-stage renal disease on maintenance hemodialysis. J Nephrol. 2002; 15: 552-557.
[44]
Raj DSC, Shah H, Shah VO, Ferrando A, et al. (2003). Markers of inflammation, proteolysis, and apoptosis in ESRD. Am K Kidney Dis. 2003; 42 (6): 1212-1220.
[45]
Philip KTL, Jack KCN, Mcintyre CW. (2017). Inflammation and Peritoneal Dialysis. Semin Nephrol. 2017; 37 (1): 54-65.
[46]
Sharharma K, Considine RV, Michael B, et al. (1997). Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients. Kidney Int. 1997. 51: 1980-1985.
[47]
Yeh SS, Schuster MW. (1999). Geriatric cachexia: the role of cytokiness. Am J Clin Nutr. 1999. 70: 183-197.
[48]
Oliveira, CMC, Kubrusly M, Mota RS, Choukroun G, Netro JB, Silva CAB. (2012). Adductor pollicis muscle thickness: a promising anthropometric parameter for patients with chronic renal failure. J Nutr Ren. 2012. 22 (3): 307-316.
[49]
Bragagnolo R, Caporossi FS, Dock-Nascimento DB, Aguiar-Nascimento JE. (2011). Handgrip strength and adductor pollicis muscle thickness as predictors of postoperative complications after major operations of the gastrointestinal tract. E Spen Eur E J Clin Nutr Metab. 2011. 6 (1): e21-e26.
[50]
Agarwal R, Andersen MJ, Pratt JH. (2008). On the Importance of Pedal Edema in Hemodialysis Patients. Clin J Am Soc Nephrol. 2008; 3 (1): 153–158.
[51]
Aguilera A, Codoceo R, Selgas R, et al. (1998). Anorexigen (TNF-alpha, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: their relationship with nutritional parameters. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Ren Assoc. 1998; 13 (6): 1476–83.
[52]
Ryden M, Arvidsson E, Blomqvist L, Perbeck L, Dicker A, Arner P. (2004). Targets for TNF-alpha-induced lipolysis in human adipocytes. Biochem Biophys Res Commun. 2004; 318: 168–75.
[53]
Mitch WE, Goldberg AL. (1996). Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med. 1996; 335: 897-905.
[54]
Ikizler TA, Pupim LB, Brouillette JR, et al. (2002). Hemodialysis stimulates muscle and whole body protein loss and alters substrate oxidation. Am J Physiol Endocrinol Metab. 2002; 282: E107-116.
[55]
Sharma, D, Hawkins M, Abramowitz MK. (2014). Association of sarcopenia with e GFR and misclassification of obesity in adults with CKD in the United States. Clin J Am Soc Nephrol. 2014; 9 (12): 2079-2088.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
CONTACT US
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
E-mail:
LET'S GET IN TOUCH
Name
E-mail
Subject
Message
SEND MASSAGE
Copyright © 2013-, Open Science Publishers - All Rights Reserved