Thyroid Hormone Abnormalities in Euthyroid Patients with Chronic Kidney disease in Abuja, Nigeria
[1]
Mathias Abiodun Emokpae, Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria.
[2]
Best Ubebe, Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria.
[3]
Joan Oghogho Osunbor, Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria.
Introduction: Chronic Kidney disease (CKD) has emerged as a global health challenge and is associated with cardiovascular diseases and increase healthcare expenditure in most countries. Thyroid gland regulates several physiological functions of the body including that of the kidney and any disorder of the kidney may impact on thyroid function. Studies on thyroid hormone abnormalities in patients with non-dialysis CKD are scarce in our setting. Objective: This study seeks to determine the pattern of thyroid hormone abnormalities in non-dialysis CKD patients attending renal clinics in Abuja metropolis. Methods: Serum thyroxine (T4), triiodothyronine (T3), thyroid stimulating hormone (TSH), urea and creatinine were analyzed in 65 adult patients with CKD and 60 control subjects by Enzyme linked Immunoabsorbent assay and Selectra ProS auto analyzer respectively. Estimated glomerular filtration rate was calculated using Cockcroft-Gault formula. Results: Thyroid hormone abnormalities were observed in 38 (58.5%) subjects with CKD while 27 (41.5%) had euthyroid status. The pattern of thyroid abnormalities observed were sick euthyroid syndrome 17 (26.1%), subclinical hypothyroidism 8 (12.3%), hypothyroidism 7 (10.8%) and hyperthyroidism 9 (9.2%). Serum creatinine correlated negatively with T4 (r = -0348; p<0.001) and positively with TSH (r = 0.286; p = 0.02). Conclusion: Thyroid function tests evaluation may be considered in some patients with CKD but careful interpretation of results is needed.
Chronic Kidney Disease, Thyroid Dysfunction, Thyroid Hormones
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