A Physicochemical Method for Glucose Controlled Release of Depot Insulin in Vitro
Ian Frederick Turnbull, PO Box 12533 Abeckett Street Melbourne Victoria Australia 8006.
Proteins, including insulin, can be release from gels made from poly-hydroxyl polymers in response to glucose in the surrounding media in vitro. The release increases with increasing glucose concentration over the range 0 to 200 mM. The result was demonstrated in normal saline at room temperature and artificial plasma at 37°C. The protein containing gels are amenable to injection through narrow gauge hypodermic needles.
Diabetes, Insulin, Smart, Depot, Release, Glucose, Responsive, Stimulated
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