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A Physicochemical Method for Glucose Controlled Release of Depot Insulin in Vitro
Current Issue
Volume 2, 2017
Issue 5 (September)
Pages: 20-24   |   Vol. 2, No. 5, September 2017   |   Follow on         
Paper in PDF Downloads: 20   Since Nov. 6, 2017 Views: 959   Since Nov. 6, 2017
Ian Frederick Turnbull, PO Box 12533 Abeckett Street Melbourne Victoria Australia 8006.
Proteins, including insulin, can be release from gels made from poly-hydroxyl polymers in response to glucose in the surrounding media in vitro. The release increases with increasing glucose concentration over the range 0 to 200 mM. The result was demonstrated in normal saline at room temperature and artificial plasma at 37°C. The protein containing gels are amenable to injection through narrow gauge hypodermic needles.
Diabetes, Insulin, Smart, Depot, Release, Glucose, Responsive, Stimulated
Diabetes - long-term effects. (2017) Available at the “better health” website of the Victorian Government; Complications of diabetes. (2017) Available at the “health direct” website of the Australian Government.
Insulin-pump. (2017) Available from the “diabetes Australia” website.
How-to-make-slime. (2017) Available from the “home science tools” website.
About Humalog® U-100. (2017) Available from the “humalog” website.
Samuel D. Jacobson, M. D.; Charley J. Smyth, M. D. Gelatin as a substitute for plasma observations on its administration to human beings. Arch Intern Med (Chic). 1944; 74 (4): 254-257. Hogan, J. J.: The Intravenous Use of Colloidal (Gelatin) Solutions in Shock, J. A. M. A. 64: 721 ((Feb. 27)) 1915.
Pierce BCA Protein Assay Kit (product/23225). (2017) Available from the “thermofisher” website.
(2017) Information available from the “bentadine” website.
The Accu-Chek® Mobile meter to monitor blood glucose. (2017) Information available from the “metermatch” website.
(2017) Information available from the “Microsoft” website.
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