Effects of Lepidium Sativum (Tuffa) on Bone Mineral Density and Symptoms in Female University Students in Makkah, Saudi Arabia: Single-Blind Randomized Trail
[1]
Hassan M. Bukhari, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
[2]
Hala M. Wahba, Home Economics Department, Faculty of Specific Education, Minufiya University, Minufiya, Egypt; Home Economics Department, Faculty of Sciences and Arts (Buljurshi) Al-Baha University, Buljurishi, KSA.
[3]
Eslam A. Header, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia; Department of Nutrition and Food Science Faculty of Home Economics Minufiya University, Minufiya, Egypt.
[4]
Anan A. Sharkar, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
[5]
Nadin A. Al-saegh, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
[6]
Saja M. Bukhari, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
[7]
Hyafa H. Aamoudi, Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia.
Background: Osteoporosis affecting millions worldwide, with up to 200 million at risk of fracture. The seeds of Lepidium sativum (LS) are used in Saudi Arabia as traditional medicine (named Tuffa) to promote healing of fractured bone. Objectives: To study the effect of Tuffa on bone mineral density (BMD) and changes on symptoms after consumption. Subjects and methods: A Clinical trial was conducted between 2014 – 2015 in 72 randomly selected university females' students. They were given daily dose of LS (2.5g for 6 weeks). A questionnaire was used for personal and bone health. Symptoms related to joint pain and stiffness and body health before and after treatment were also measured. BMD measured by DEXA. Results: Osteopenia occurred but no osteoporotic cases were reported, with significant changes from baseline after treatment from 40% osteopenic cases to 30.6%. T-Score at baseline improved from ـ0.702±1.038 to -0.61±0.984 after treatment. Total BMD was 1.078±0.103 lowered to 1.067±0.092; Hip BMD was 0.904±0.134 lowered to 0.8732±0.133. Spinal (BMD) was 1.0092 ±0.134 increased to 1.0172±0.126, only the hip and T-score changes were significant (P<0.05). Stiffness and pain in the knee joints, hair loss, and dizziness improved after treatment (P<0.05) Conclusion: Tuffa (L.S.) improves bone structure and health related symptoms. A good herbal medicine may protect young adults, particularly those with family history and poor dietary and life style.
Osteoporosis, Osteopenia, Lepidium Sativum, Tuffa, BMD, Makkah, Saudi Arabia
[1]
Brian K A, Koda-Kimble, M A, Young, LY, Wayne A K, B. Joseph G. Applied therapeutics: the clinical use of drugs. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins: 2009. pp. 101–3.
[2]
Elshal, M F, Almalki, A L, Hussein, H K, Khan, J A. Synergistic antiosteoporotic effect of Lepidiumsativum and alendronate in glucocorticoid-induced osteoporosis in Wistar rats. African journal of traditional, complementary, and alternative medicines. 2013: 10 (5): 267–273.
[3]
Alissa, E M, Alnahdi, W, Alama, N, Ferns, G A. Relationship between nutritional profile, measures of adiposity, and bone mineral density in postmenopausal Saudi women. J Am Coll Nutr. 2014: 33 (3): 206-14.
[4]
Tabatabaei-Malazy O, Larijani B, Abdollahi. Targeting metabolic disorders by natural Products. Journal of Diabetes & Metabolic Disorders. 2015: 14 (57): 1-21.
[5]
Lin JT, Lane JM. Osteoporosis: a review. Clin. Orthop. Relat. Res. 2004: 425: 126-34.
[6]
Giannoudis P, Tzioupis C, Almalki T, Buckley R. Fracture healing in osteoporotic fractures: Is it really different: A basic science perspective. Injury. 2007: 38: S90-S99.
[7]
Sadat-Ali M, Al-Habdan IM, Al-Turki HA, Azam MQ. An epidemiological analysis of the incidence of osteoporosis and osteoporosis-related fractures among the Saudi Arabian population. Ann Saudi Med. 2012: 32 (6): 637-41.
[8]
Chhavi S, Sushma D, Ravinder V, Anju D, Sharma. Recent Update On Bone Proficient Fracture Revivifying Herbs. International Research Journal of Pharmacy. 2011: 2 (11): 3-5.
[9]
Reuter C, Stein C, Vargas D M. Bone mass and body composition in college students. Rev Assoc Med Bras. 2012: 58 (3): 328-334.
[10]
Hammad L. F. and Benajiba N., 2017, Lifestyle factors influencing bone health in young adult women in Saudi Arabia, African health sciences. 2017: 1 (2): 524-531.
[11]
Ketchen EE, Porter WE, Bolton NE. The biological effects of magnetic fields on man. Am Ind Hyg Assoc J. 1978: 39 (1): 1-11.
[12]
Ageel AM, Tariq M, Mossa JS, Al-Yahya MA, Al-Said MS, Plants Used in Saudi Folk Medicine. Riyadh, Saudi Arabia: KACST, King Saud University Press. (1987): pp. 245–415.
[13]
Qudamah A. Dictionary of Food and Treatment by Plants. 1st edition. Beirut: Dar Alnafaes. 1995: pp. 241–244.
[14]
Madaleno I M. Traditional Medicinal Knowledge in India and Malaysia. Pharmacognosy Communications. 2015: 5 (2): 116-126.
[15]
Ahsan SK, Tariq M, Ageel M, Alyahya MA, Shah AH. Studies on some herbal drugs used in fracture healing. Pharm. Biol. 1989: 27: 235-239.
[16]
Juma AH. The Effects of Lepidiumsativum Seeds on Fracture- Induced Healing in Rabbits. Med. Gen. Med. 2007: 9 (2): 23.
[17]
Agarwal N, Sharma S. Appraisal of Garden Cress (LepidiumSativumL.) and Product Development as an all Pervasive and Nutrition Worthy Food Stuff. Annals, Food Science and Technology. 2013: 14 (1): 77-84.
[18]
Verayachankul T, Chatsiricharoenkul S, Harnphadungkit, Jutasompakorn P, M. D, Tantiwongse J, Piwtong M, et al. Single-Blind Randomized Controlled Trial of Poly-Herbal Formula Sahatsatara for Acute Low Back Pain: A Pilot Study. Siriraj Med J. 2016: 68: 30-36.
[19]
Kumar P, Jadhav N. V., Awati B., Ravikant, Mani S, Adarsh. Potentiating Activity Of Herbs Along With Calcium And Phosphorous To Improve The Meat Quality Parameters In Broilers. International Journal Of Science, Environment and Technology. 2016: 5 (3): 1066 –1074.
[20]
Jivapetthai A, Pathomwichaiwat T, Ochareon P, Prathanturarug S. In Vitro Bone Formation Inducing Activity Of Selected Thai Traditional Formulations For The Promotion Of Women’s. Health J Health Res. 2014: 28 (4): 233-239.
[21]
Raval ND, Ravishankar B, Ashok BK. Anti-inflammatory effect of Chandrashura (Lepidiumsativum Linn.) an experimental study. Ayu. 2013: 34 (3): 302-304.
[22]
Wellness library, available: www.livingnaturally.com, visited on 3-10-2016.
[23]
Raval N, Pandya TN. Clinical Trial of LepidiumSativum Linn (Chandrashura) in the Management of Sandhivata (Osteoarthritis). AYU. 2009: 30 (2): 153-157.
[24]
WHO Scientific Group. The Prevention and Management of Osteoporosis. "Prevention and management of osteoporosis. Report of a WHO scientific group. WHO technical report series; 921 Geneva: World Health Organization press. 2007: pp. 5-31.
[25]
Ardawi MSM, Maimany. A, Bahksh T M, Nasrat H A N, Milaat W A, Al-Raddadi R M. Bone mineral density of the spine and femur in healthy Saudis. Osteoporosis Int. 2005: 16: 43-55.
[26]
Soon-Nam C, Nam-Y C, Chang-Ho S, Sang-R K. Bone Density and Nutrient Intake of University Student. Journal of the Korean Society of Food Culture. 2007: 22 (6): 841-847.
[27]
Saadi HF, Reed RL, Carter AO, Qazaq HS, Al-Suhaili AR. Bone density estimates and risk factors for osteoporosis in young women. East Mediterr Health J. 2001: 7 (4-5): 730-7.
[28]
Jae Ok Koo, Myung Kim Analysis of BMI, blood pressure, cholesterol, BMD and nutrient intake with different age of adult women in Korea. The FASEB Journal. 2014: 28 (1) Supplement 1027.4.
[29]
El Sawy N A, Bukhari H M, Saad Nada I, Header E. Obesity and Osteoporosis Among Students in Umm Al-Qura University Makkah, KSA. VRI Bio Med Chem. 2014: 2 (2): 13-24.
[30]
Wehbe J, Cortbaoui C, Chidiac RM, Nehme A, Melki R, Bedran F et al. Age-associated changes in Quantitative Ultrasonometry (QUS) of the oscalcis in Lebanese women – assessment of a Lebanese reference population. J Musculoskelet Neuronal Interact. 2003: 3: 232-239.
[31]
Greer W, Mohammed A, Ayman R, and Anne F. Interpreting low normative bone mineral density among Saudi Arabian women. A Qatar Foundation Journal, Avicenna. 2010: 2.
[32]
Bener A, Hammoud M, Zirie M. Prevalence and predictors of osteoporosis and the impact of, life style factors on bone mineral density. APLAR Journal of Rheumatology. 2007: 10: 227–233.
[33]
Qu Y, Wong M, Thiebaud D, Stock JL. The effect of raloxifenetherapy on the risk of new clinical vertebral fractures at three andsix months: a secondary analysis of the MORE trial. Curr Med ResOpin. 2005: 21: 1955–1959.
[34]
Licata A. Bone density vs bone quality: What’s a clinician to do? Cleveland Clinic journal of Medicine. 2009: 7 (6): 6-17.
[35]
Bastihalli T D, Belur R, Kamatham A N. Modulatory effect of a-linolenic acid-rich garden cress (Lepidiumsativum L.) seed oil on inflammatory mediators in adult albino rats. British Journal of Nutrition. 2011: 106: 530–539.
[36]
Yogesh C Y, Avijeet J. Srivastava, Anurekha J. Fracture healing activity of ethanolic extract of lepidiumsativum l. Seeds in internally fixed rats’ femoral osteotomy model. International Journal of Pharmacy and Pharmaceutical Sciences. 2011: 3: Suppl 2.
