Synthesis and Biological Activity of Novel Hydrazide-Hydrazones Incorporating Piperidine and Piperazine Moieties and Related Mannich Bases
Reaction of the hydrazide 2, or the bis(hydrazide) 8, with the appropriate aromatic aldehyde gave the new hydrazide-hydrazones 3a-g and 9a-g, respectively. Mannich reaction of 3e-g and 9e-g, with formalin and piperidine afforded the corresponding phenolic Mannich bases 4-6 and 10-12. The chemical structures of the prepared compounds were elucidated using spectral data. The biological activity including antioxidant and antimicrobial activity of the synthesized compounds were investigated. Compounds 3b, 3e, 3g and 9b showed the highest antioxidant activity, while the antimicrobial activity of compounds 3e, 3g and 9b showed the highest activity against E. coli. Moreover, compounds 3b, 3e, 3g, 9b and 9g have highest activity against S. aureus, and compounds 3b, 3e, 3g and 9g showed highest activity against C. Albicans.
Hydrazide-Hydrazones, Bis (Hydrazide-Hydrazones), Phenolic Mannich Bases
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