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Hepatotoxic Potentials of Allium sativum (Garlic) Following Varying Concentrations in Adult Male Wistar Rats
Current Issue
Volume 5, 2017
Issue 2 (April)
Pages: 7-11   |   Vol. 5, No. 2, April 2017   |   Follow on         
Paper in PDF Downloads: 32   Since Aug. 2, 2017 Views: 1154   Since Aug. 2, 2017
Authors
[1]
Idehen I. Charles, Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
[2]
Bankole J. Kayode, Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
[3]
Airhomwanbor Kingsley, Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
[4]
Dic-Ijiewere O. Ebenezer, Department of Chemical Pathology, Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
[5]
Eidangbe A. Peace, Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
[6]
Iyamu O. Anthony, Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
[7]
Uwuigbe Matthew, Department of Medical Laboratory Sciences, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
Abstract
It is the aim of this study to investigate the effect of varying concentration of Allium sativum (garlic) on the histology of the liver. The study was conducted on 30 adult male Wistar rats of comparable weight (150-200mg/kg) divided into 6 groups; A to F. Group A (control group) receives normal rat chow and water while Group B to F (test groups) received normal rat chow, water plus 200mg/kg bwt, 400mg/kg bwt, 600mg/kg bwt, 800mg/kg bwt and 1000mg/kg bwt of garlic powder respectively for 21 days. At the end of the experiment, the liver of the rats were harvested and fixed in 10% formal saline for histological processing. The findings of this study showed that ingestion of graded concentration of garlic ranging between 200mg/kg and 800mg/kg over a period of 21 days did not induce any hepatic change. However, at a dose of 1000mg/kg bwt, garlic possess hepatotoxic potential ranging from moderate portal congestion/Hemorrhage to mild hepatocytes loss. Judging by these findings, garlic is relatively safe but can be hepatotoxic at dose above 1000mg/kg bwt.
Keywords
Histology, Liver, Allium sativum, Garlic
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