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Haematopoietic Activity of Ficus exasperata Vahl. (Moraceae) Leaf Methanol Extract in Albino Rats
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Volume 3, 2015
Issue 5 (October)
Pages: 39-42   |   Vol. 3, No. 5, October 2015   |   Follow on         
Paper in PDF Downloads: 35   Since Sep. 3, 2015 Views: 1498   Since Sep. 3, 2015
Ukwubile Cletus Anes, Department of Science Laboratory Technology, Federal Polytechnic Bali, Taraba State, Nigeria.
Cynthia Tindak Samagoro, Department of Pharmacognosy and Drug Development, Gombe State University, Gombe, Nigeria.
Odugu Jude N., Department of Medical Microbiology, Ahmadu Bello University Teaching Hospital Shika, Zaria Nigeria.
Twenty (20) albino rats of both sexes were divided into five groups of four animals each and tested for body weight as well as haematological parameters such as: PCV, WBC, HB, RBC, MCV, MCHC and MCH methanol leaf extract of F. exasperata. The test groups II, III, IV and V were fed with extract doses of 100, 200, 300 and 400mg/kg body weight of mice respectively by oral means for two weeks. Initial weights of the rats and weights after feeding were taken, and then the animals were sacrificed after two weeks. Blood samples collected from the sacrificed animals were analysed for haematological parameters. Results showed that weights of the animals increase as the doses increase in all the groups except for the control group (I) where the animals were given ordinary water. General decreases in haematological parameters PCV, HB, WBC, MCHC and MCV were witnessed whilst the RBC showed significant increases (P≤0.05) compared with the control value 5.05 ± 0.31x106 mm3. The study indicated that long term use of the leaves of F. exasperata as an oral medication in traditional medicine was not safe at the doses investigated in this study, as the weight increase in the animals may be due to hypertrophy (swollen organs) except in the control group without the extract.
Haematopoietic, Ficus exasperata, Albino Rats, Haematological
Gbile E, Onuku JO, Nuhu HI, Agunu A. Plant Polyphenol: Vegetal Tannin Reenlisted Chemistry and Pharmacology of Natural Products, Cambridge University Press 2008: 169-170.
Burkill HM. The Useful Plants of West Tropical Africa 2nd (Ed): Royal Botanic Garden. Kew 2012: 50.
Abbiw T.Study of Tropical Shrubs and Plants. Journal of Biogeography 2013; 23(15): 591-602.
Hallen F. Woody Plants of Ghana with Special Reference to their Uses; Oxford University Press, London 2013: 868.
IjehII, Ukweni IO. The Toxic Effects of Prolonged Administration of Chloramphenicol on the Liver and Kidney of Rats. African J. Biomed. Res.2007; 3(3):133-137.
Cletus AU. The effect of aqueous seed of Trigonellifoenumgraecom (Fenugreek) on Haematological Parameter in Albino Rats. Afri. J. Biomed. Res 2010; 7(8): 47-51.
Abayomi A. A Text Book for Medical Laboratory Practice. Edison Books Centre, Lagos 2007: 181-208.
OchieJ, Kolhatkar A. Medical Laboratory Theory and Practice. Mc Grew-Hills Companies, New Delhi 2014:286-289.
WHO. Standard methods on Haematological indices 2012; 34(67): 100-123.
Neha Y, Priyanka S, Sitara J, Suruchi K, Sarita K, Sushma KV, Bhartis SR, Shinha MP. Effect of Methanol Extract of Paratheniumhysterophorus L. on Haematological Parameter in Wistar Albino Rat.Int. Quart. J. life science 2010; 5 (2): 357-363.
Adebayo AF, Adesina F, Obi FE. Toxicology potentials of Calotropis proceraleaves on some vital organs of albino mice. Journal of Applied Biology 2013; 5(2): 50-54.
Choudhari CV, Deshmukh PB. Acute and Sub chronic Toxicity Study of Semecarpusanacardium on Haemoglobin Percent and RBC Count of Male 2007. In: Muna CA and Jones KB. Clinical pathology 2nd edition. Elsevier 2009: 290-293
Lawrence DR, Bennett PN, Brown MS. Chemical Pharmacology 8th (Ed). Longman Publisher Ltd, Singapore 1997: 465-466.
Ganong WF. A Review of Medical Physiology 20th (Ed). Appleton and Large 2005: 369-382.
Amresh GR, Singh PN, Rio VC. Toxicology, Screening of Traditional Medicine Laghupatha (Cissampelos) Pareira in Experimental Animals. J. Ethnopharmacolo. 2008;116: 454-460.
Ashafa AOT, Summonu TO, Afolayan AJ. Effect of Leaf and Berry Extract of Phytolacca dioica L. on Haematological and Weight Parameter of Wistar Rats. Afr. J. Pharmacy and Pharmacolo. 2010; 5 (2): 150-154.
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