Comminution Kinetics of α and γ-glycine Polymorphs in a Planetary Ball Mill
[1]
Gordana Matijašić, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
[2]
Vanda Mandić, INA - Industrija Nafte, d.d., Rafinerija Nafte Rijeka, Rijeka, Croatia.
[3]
Krunoslav Žižek, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
[4]
Jasna Prlić Kardum, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
[5]
Martina Hrkovac, PLIVA Hrvatska d.o.o., Zagreb, Croatia.
[6]
Vilko Mandić, Ruđer Bošković Institute, Zagreb, Croatia.
Glycine is the important amino acid that functions as inhibitory neurotransmitter and therefore has been a topic of many researches. This work deals with modeling of the comminution process for glycine crystals. Three different glycine samples (two γ and one α form) were prepared by batch cooling crystallization and afterwards comminuted in a planetary ball mill. Comminution kinetics was investigated using the analytical solution of population balance. Crystal size distribution was expressed with Sauter's mean diameter and modeled using simple first-order breakage kinetic with a milling limit. Results showed the obtained models can be used to predict crystal size distribution during the comminution process. PXRD analysis showed there was no mechanically induced solid-state polymorphic phase transformation of glycine.
Glycine, Crystal Size Distribution, Comminution Kinetics, Population Balance, Polymorph
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