Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Comminution Kinetics of α and γ-glycine Polymorphs in a Planetary Ball Mill
Current Issue
Volume 4, 2017
Issue 5 (September)
Pages: 57-65   |   Vol. 4, No. 5, September 2017   |   Follow on         
Paper in PDF Downloads: 111   Since Aug. 2, 2017 Views: 1366   Since Aug. 2, 2017
Gordana Matijašić, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Vanda Mandić, INA - Industrija Nafte, d.d., Rafinerija Nafte Rijeka, Rijeka, Croatia.
Krunoslav Žižek, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Jasna Prlić Kardum, Faculty of Chemical Engineering and Technology, University of Zagreb, Zagreb, Croatia.
Martina Hrkovac, PLIVA Hrvatska d.o.o., Zagreb, Croatia.
Vilko Mandić, Ruđer Bošković Institute, Zagreb, Croatia.
Glycine is the important amino acid that functions as inhibitory neurotransmitter and therefore has been a topic of many researches. This work deals with modeling of the comminution process for glycine crystals. Three different glycine samples (two γ and one α form) were prepared by batch cooling crystallization and afterwards comminuted in a planetary ball mill. Comminution kinetics was investigated using the analytical solution of population balance. Crystal size distribution was expressed with Sauter's mean diameter and modeled using simple first-order breakage kinetic with a milling limit. Results showed the obtained models can be used to predict crystal size distribution during the comminution process. PXRD analysis showed there was no mechanically induced solid-state polymorphic phase transformation of glycine.
Glycine, Crystal Size Distribution, Comminution Kinetics, Population Balance, Polymorph
Cheong YS, Mangwandi C, Fu J, Adams MJ, Hunslow MJ, Salman AD, Handbook of Powder Technology. Amsterdam: Elsevier, 2007.
Müller F, Polke RF. From the product and process requirements to the milling facility. Powder Technology. 1999; 105: 2-13.
Boldyreva EV, Drebushchak VA, Drebushchak TN, Paukov IE, Kovalevskaya YA, Shutova ES. Polymorphism of glycine. Thermodynamic aspects. Part I. Relative stability of the polymorphs. Journal of Thermal Analysis and Calorimetry. 2003; 73: 409-418.
Bouchard A, Hofland GW, Witkamp GJ. Solubility of glycine polymorphs and recrystallization of -glycine. Journal of Chemical Engineering Data. 2007; 52: 1626-1629.
Drebushchak VA, Boldyreva EV, Drebushchak TN, Shutova ES. Synthesis and calorimetric investigation of unstable β-glycine. Journal of Crystal Growth. 2002; 241: 266-268.
Hughes CE, Harris KDM. Direct observation of a transient polymorph during crystallization. Chemical Communication. 2010; 46: 4982-4984.
Balakrishnan T, Ramesh Babu R, Ramamurthi K. Growth, structural, optical and thermal properties of -glycine crystal. Spectrochimica Acta Part A. 2008; 69: 1114-1118.
Srinivasan K. Crystal growth of and  glycine and their polymorphic phase transition. Journal of Crystal Growth. 2008; 311: 156-162.
Louhi-Kultanen M, Karjalainen M, Rantanen J, Huhtanen M, Kallas J. Crystallization of glycine with ultrasound. International Journal of Pharmaceutics. 2006; 320: 23-29.
Matsuoka M, Hirata J, Yoshizawa S. Kinetics of solid-state polymorphic transition of glycine in mechano-chemical processing. Chemical Engineering Research and Design. 2010; 88: 1169-1173.
Boldyreva E V, Drebushchak V A, Drebushchak T N, Paukov I E, Kovalevskaya Y A & Shutova E S. Polymorphism of glycine. Thermodynamic aspects. Part II. Polymorphic transition. Journal of Thermal Analysis and Calorimetry. 2003; 73: 419-428.
Choi H, Lee J, Hong H, Gu J, Lee J, Yoon H, Choi J, Jeong Y, Song J, Kim M, Ochirkhuyag B. New evaluation method for the kinetic analysis of the grinding rate constant via the uniformity of particle size distribution during a grinding process. Powder Technology. 2013; 247: 44-46.
Fuerstenau DW, Phatak PB, Kapur PC, Abouzeid AZM. Simulation of the grinding of coarse/fine (heterogeneous) systems in a ball mill. International Journal of Mineral Processing. 2011; 99: 32-38.
Yang W, Kwan CC, Ding YL, Ghadiri M, Roberts KJ. Milling of sucrose. Powder Technology. 2007; 174: 14-17.
Kwan CC, Chen YQ, Ding YL, Papadopoulos DG, Bentham AC, Ghadiri M. Development of a novel approach towards predicting the milling behaviour of pharmaceutical powders. European Journal of Pharmaceutical Science. 2004; 23: 327-336.
Hrkovac M, Prlić Kardum J, Schuster A, Ulrich J. Influence of additives on glycine crystal characteristics. Chemical Engineering and Technology. 2011; 34: 611-618.
Matijašić G, Kurajica S. Grinding kinetics of amorphous powder obtained by sol-gel process. Powder Technology. 2010; 197: 165-169.
Choi WS, Chung HY, Yoon BR, Kim SS. Applications of grinding kinetics analysis to fine grinding characteristics of some inorganic materials using a composite grinding media by planetary ball mill. Powder Technology. 2001; 115: 209-214.
Hogg R. Breakage mechanisms and mill performance in ultrafine grinding. Powder Technology. 1999; 105: 135-140.
Austin LG. A discussion of equations for the analysis of batch grinding data. Powder Technology. 1999; 106: 71-77.
Shinohara K, Golman B, Uchiyama T & Otani M. Fine-grinding characteristics of hard materials by attrition mill. Powder Technology. 1999; 103: 292-296.
Nakajima Y, Tanaka T. Solution of batch grinding equation. Industrial & Engineering Chemistry Process Design and Development. 1973; 12: 23-25.
Perlovich GL, Hansen LK, Bauer-Brandl A. The polymorphism of glycine. Thermochemical and structural aspects. Journal of Thermal Analysis and Calorimetry. 2001; 66: 699-715.
Gusseme AD, Neves C, Willart JF, Rameau A, Descamps M. Ordering and disordering of molecular solids upon mechanical milling: the case of fananserine. Journal of Pharmaceutical Science. 2008; 97: 5000-5012.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
Copyright © 2013-, Open Science Publishers - All Rights Reserved