Design, Implementation and Assessment of a Novel Intermittent Controllable Bioreactor for Supplying High Compression
[1]
Zhang Yu, Department of Physical Education, Dalian University of Technology, Dalian, China; State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China.
[2]
Li Pengsong, Department of Physical Education, Dalian University of Technology, Dalian, China.
[3]
Sha Li, Coll Basic Med, Dalian Medical University, Dalian, China.
[4]
Cao Xuejiao, Coll Basic Med, Dalian Medical University, Dalian, China.
[5]
Dong Haichao, Department of Orthopaedics, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
[6]
Song Kedong, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China.
[7]
Liu Tianqing, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, China.
One third of meniscus is white-white zone, composed of chondrocyte and extracellular matrix composition, and its regeneration ability is extremely limited. That leads to the damage which is not cured itself. At present, with the rapid progress of the construction of the meniscus in vitro, tissue engineering is the promising method for this question. Bioreactor systems play an important role in tissue engineering, as they enable reproducible and controlled changes in specific environmental factors. This work is based on afore research to design of a three-dimensional, hydrostatics multi parameter simulation, to simulate human menisci microenvironment system, meeting the scale expansion of seed cells, designing and constructing an intermittent controllable bioreactor with high-compression for reconstruction of meniscus in vitro.
Intermittent, Controllable, Bioreactor, High-Compression, Meniscus, Three-Dimensional Construction
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