The Silver nanoparticles have been widely used as new potent antimicrobial agents in cosmetic and hygienic products, as well as in new medical devices. Silver compounds have also been used for centuries for healing purposes because of the broad spectrum antibiotic, and have been proven to be effective in both, retarding and preventing bacterial infections and healing wounds. In this study the evaluation of healing properties of Silver nanoparticles has done by using hydrophilic ointment containing nanosilver. This ointment was prepared and used for anti-inflammatory and wound healing study. In the study of silver nanoparticls effect on anti-inflammatory study showed reduces edema with 91% (inhibition percentages) as compared to standard which showed 81% (inhibition percentages). In further study of Silver nanoparticle had shown significant therapeutic activity in excision wound study. In this study the mean percentage closure of wound for AgNP used in 1% of concentration had shown better result with 95.28% in comparison with standard which was around 93.71%. This was further confirmed by the collagen and epithelization studies. There was significant difference between the entire group and the 1% AgNP ointment was found to be highly effective. As the collagen synthesis is the first step due to the formation of precursor polypepetide such as lysine and proline residues. The remolding of scar tissue occurs due to the fast inter molecular and intra molecular cross linking of collagen. Collagen not only confers strength and integrity to the tissue matrix but also plays an important role in hemostasis and epithelialization at alater phase of wound healing. With this study we can state that the use of Silver nanoparticles in cosmetic formulation can help in reducing wrinkles and increase the firmness of the skin as well as it can be used in anti-acne preparation efficiently.

Silver Nanoparticle, Wound Healing, Cosmetic, Acne, Antiaging, Skin Rejuvenation, Collagen Booster