Management of Treatment Resistant Depression – A Systematic Review
[1]
Balasubramanian Thirumalaisamy, Department of Pharmacology, Al Shifa College of Pharmacy, Kerala, India.
[2]
Lina Elizabeth Cherian, Department of Pharmacy Practice, Al Shifa College of Pharmacy, Kerala, India.
[3]
Balan Paramasivam, Department of Pharmaceutical Chemistry, Al Shifa College of Pharmacy, Kerala, India.
[4]
Jisna Jamal, Department of Pharmacy Practice, Al Shifa College of Pharmacy, Kerala, India.
[5]
Mumthas Arpurath Habeeb, Department of Pharmacy Practice, Al Shifa College of Pharmacy, Kerala, India.
[6]
Murshid Cheriyeri Peediyekal, Department of Pharmacy Practice, Al Shifa College of Pharmacy, Kerala, India.
Treatment resistance is an emerging issue faced by physicians worldwide. Treatment resistant depression is a severely disabling disorder which affects about 30-46% of patients with major depressive disorder. Depression is defined treatment resistant in patients who failed different classes of two or more antidepressants with adequate treatment dosages and durations. The aim of this paper is to review the available management strategies of treatment resistant depression and provide an overall idea in this disease. Usual management strategies that are suggested to deal with treatment resistant depression include optimizing the existing treatment, switching to another antidepressant, augmentation strategies, combination of antidepressants, adding psychotherapy and ECT and other non-pharmacologic therapies.
Treatment Resistance Depression, Antidepressants, Pharmacological Management
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