Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
The Importance of Hypochondriasis in Dyspeptic Patients
Current Issue
Volume 5, 2018
Issue 1 (March)
Pages: 1-9   |   Vol. 5, No. 1, March 2018   |   Follow on         
Paper in PDF Downloads: 68   Since Apr. 27, 2018 Views: 1062   Since Apr. 27, 2018
Michel Bouchoucha, Department of Physiology, Université Paris V René Descartes, Paris, France; Service de Gastroentérologie, Hôpital Avicenne, Bobigny, France.
Maria Hejnar, Service de Psychiatrie et de psychopathologie, Hôpital Avicenne, Bobigny, France.
Pierre Rompteaux, Service de Gastroentérologie, Hôpital Avicenne, Bobigny, France.
Gheorghe Airinei, Service de Gastroentérologie, Hôpital Avicenne, Bobigny, France.
Florence Mary, Service de Gastroentérologie, Hôpital Avicenne, Bobigny, France.
Robert Benamouzig, Service de Gastroentérologie, Hôpital Avicenne, Bobigny, France.
Psychological factors are involved in functional dyspepsia and irritable bowel syndrome. The aim of the study was to characterize the psychological factors associated with functional dyspepsia (FD) with or without overlap with irritable bowel syndrome (IBS). We included 693 outpatients (69% female) consulting in a tertiary center for functional gastrointestinal disorders (FGIDs) in this cross sectional study. Patients have filled a MMPI-2 questionnaire and a standard Rome III clinical questionnaire. Data analysis was performed using univariate analysis and multivariate logistic regression. Dyspeptic disorders without IBS were found in 139 patients (20%) (21 had epigastric pain syndrome, 46 postprandial distress syndrome, 72 nonspecific dyspepsia), 214 patients (31%) had overlap between FD and IBS, 68 patients (10%) have only IBS, and 272 (39%) had other FGIDs. These groups show no difference for age, stool form, but patients with overlap between FD and IBS have more frequently female gender (P<0.05) and all dyspeptic patients had lower BMI than patients with other FGIDs. As compared to the group "other FGIDs" patients, the multivariate analysis shows that patients with isolated FD are associated with lower BMI (P=0.002; OR=0.921; 95% CI=[0.874-0.970]), and higher hypochondriasis scale (P<0.001; OR=1.096; 95% CI=[1.061-1.133]), patients with overlap of IBS and FD are associated with lower BMI (P=0.001; OR=0.929; 95% CI=[0.888-0.972]), higher Infrequency scale (P=0.013; OR=1.035; 95% CI=[1.007-1.063]), higher hypochondriasis scale (P<0.001; OR=1.095; 95% CI=[1.064-1.127]) and lower schizophrenia scale (P=0.036; OR=0.959; 95% CI=[0.921-0.997]). To conclude high hypochondriasis scales are found in FD patients and in patients with overlap between IBS and dyspepsia.
Hypochondriasis, Dyspepsia, Irritable Bowel Syndrome, Personality, MMPI, Depression, Anxiety
Tack, J., et al., Functional gastroduodenal disorders. Gastroenterology, 2006. 130(5): p. 1466-79.
Alander, T., et al., Psychological illness is commonly associated with functional gastrointestinal disorders and is important to consider during patient consultation: a population-based study. BMC Med, 2005. 3: p. 8.
Longstreth, G. F., et al., Functional bowel disorders. Gastroenterology, 2006. 130(5): p. 1480-91.
Bouchoucha, M., G. Devroede, and M. Arsac, Anismus: a marker of multi-site functional disorders? Int J Colorectal Dis, 2004. 19(4): p. 374-9.
Drossman, D. A., The functional gastrointestinal disorders and the Rome III process. Gastroenterology, 2006. 130(5): p. 1377-90.
Agreus, L., et al., Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. Gastroenterology, 1995. 109(3): p. 671-80.
Quigley, E. M., et al., A global perspective on irritable bowel syndrome: a consensus statement of the World Gastroenterology Organisation Summit Task Force on irritable bowel syndrome. J Clin Gastroenterol, 2012. 46(5): p. 356-66.
Engel, G. L., The need for a new medical model: a challenge for biomedicine. Psychodyn Psychiatry, 2012. 40(3): p. 377-96.
Tanaka, Y., et al., Biopsychosocial model of irritable bowel syndrome. J Neurogastroenterol Motil, 2011. 17(2): p. 131-9.
Drossman, D. A., et al., Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome. Gastroenterology, 1988. 95(3): p. 701-8.
Talley, N. J., et al., Relation among personality and symptoms in nonulcer dyspepsia and the irritable bowel syndrome. Gastroenterology, 1990. 99(2): p. 327-33.
Bennett, E. J., et al., Level of chronic life stress predicts clinical outcome in irritable bowel syndrome. Gut, 1998. 43(2): p. 256-61.
Soo, S., et al., Psychological interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev, 2005(2): p. CD002301.
Kawakami, H., et al., Personality deviation and gastric motility in patients with functional dyspepsia. J Clin Gastroenterol, 1995. 21 Suppl 1: p. S179-84.
Mahadeva, S. and K. L. Goh, Letter: dyspepsia, anxiety and depression. Aliment Pharmacol Ther, 2013. 37(1): p. 166-7.
Mak, A. D., et al., Dyspepsia is strongly associated with major depression and generalised anxiety disorder - a community study. Aliment Pharmacol Ther, 2012. 36(8): p. 800-10.
Van Oudenhove, L., et al., Depression and Somatization are Associated with Increased Postprandial Symptoms in Patients With Irritable Bowel Syndrome. Gastroenterology, 2016.
Mahadeva, S. and K. L. Goh, Anxiety, depression and quality of life differences between functional and organic dyspepsia. J Gastroenterol Hepatol, 2011. 26 Suppl 3: p. 49-52.
Lee, S. P., et al., The effect of emotional stress and depression on the prevalence of digestive diseases. J Neurogastroenterol Motil, 2015. 21(2): p. 273-82.
Haug, T. T., et al., Psychological factors and somatic symptoms in functional dyspepsia. A comparison with duodenal ulcer and healthy controls. J Psychosom Res, 1994. 38(4): p. 281-91.
Haug, T. T., et al., Life events and stress in patients with functional dyspepsia compared with patients with duodenal ulcer and healthy controls. Scand J Gastroenterol, 1995. 30(6): p. 524-30.
Whitehead WE and the Validation Working Team in Association with the Rome Questionnaire Committee, Development and Validation of the Rome III Diagnostic Questionnaire., in Rome III: The functional gastrointestinal disorders., C. E. Drossman DA, Talley NJ, Al e (eds.):, Editor. 2006., Degnon Associates: Mc Lean, VA.
Galmiche, J. P., et al., Functional esophageal disorders. Gastroenterology, 2006. 130(5): p. 1459-65.
Clouse, R. E., et al., Functional abdominal pain syndrome. Gastroenterology, 2006. 130(5): p. 1492-7.
Bharucha, A. E., et al., Functional anorectal disorders. Gastroenterology, 2006. 130(5): p. 1510-8.
Graham, J. R., MMPI-2: Assessing Personality and Psychopathology 5th ed. 2011, Oxford: Oxford University Press. 688.
Butcher, J. N., et al., The Minnesota Multiphasic Personality Inventory-2 (MMPI-2): Manual for administration and scoring. 1989, Minneapolis, MN: University of Minnesota Press.
Alpers, D. H., Why should psychotherapy be a useful approach to management of patients with nonulcer dyspepsia? Gastroenterology, 2000. 119(3): p. 869-71.
O'Malley, P. G., et al., The value of screening for psychiatric disorders prior to upper endoscopy. J Psychosom Res, 1998. 44(2): p. 279-87.
Shukla, G. D., D. N. Mishra, and A. K. Agarwal, Non-organic dyspepsia: a controlled psychometric study. Indian J Psychiatry, 1982. 24(3): p. 280-3.
Van Oudenhove, L. and J. Tack, New epidemiologic evidence on functional dyspepsia subgroups and their relationship to psychosocial dysfunction. Gastroenterology, 2009. 137(1): p. 23-6.
Hamilton, J., et al., A randomized controlled trial of psychotherapy in patients with chronic functional dyspepsia. Gastroenterology, 2000. 119(3): p. 661-9.
Aro, P., et al., Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study. Gastroenterology, 2009. 137(1): p. 94-100.
Barcelo, M., et al., Weight Gain and Somatization are Associated With the Onset of Gastroesophageal Reflux Diseases: Results of Two 5-year Follow-up Studies. J Clin Gastroenterol, 2015.
Andersson, S. I., et al., Dyspepsia in general practice: psychological findings in relation to Helicobacter pylori serum antibodies. J Psychosom Res, 1994. 38(3): p. 241-7.
Marce, L. V., Note sur une forme de délire hypocondriaque consécutive aux dyspepsies et caractérisée principalement par le refus d’aliments. Annales médico-psychologiques, 1860. 3(6): p. 15-28.
Frank, J.-P., Traité de médecine pratique. Vol. 2. 1842, Paris: J-B Baillière.
Hare, E., The history of 'nervous disorders' from 1600 to 1840, and a comparison with modern views. Br J Psychiatry, 1991. 159: p. 37-45.
Devroede, G., et al., Idiopathic constipation by colonic dysfunction. Relationship with personality and anxiety. Dig Dis Sci, 1989. 34(9): p. 1428-33.
Brousset, B., L’Hypocondrie: Thématique ou Organisation spécifique ? Revue Française de psychosomatique, 2002. 2(22): p. 45-64.
Hathaway, S. R., A coding system for MMPI profile classification. J Consult Psychol, 1947. 11(6): p. 334-7.
Thumshirn, M., et al., Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function. Gut, 1999. 44(1): p. 55-64.
Heymen, S., S. D. Wexner, and A. D. Gulledge, MMPI assessment of patients with functional bowel disorders. Dis Colon Rectum, 1993. 36(6): p. 593-6.
Butcher, J. N. and C. L. Williams, Essentials of MMPI-2 and MMPI-A Interpretation. Vol. 1. 2000, Minneapolis, MN 55401: University of Minnesota Press. 447.
Strid, H., et al., Impact of sex and psychological factors on the water loading test in functional dyspepsia. Scand J Gastroenterol, 2001. 36(7): p. 725-30.
Faramarzi, M., et al., Psychological factors in patients with peptic ulcerand functional dyspepsia. Caspian J Intern Med, 2014. 5(2): p. 71-6.
Nan, J., et al., Brain-based Correlations Between Psychological Factors and Functional Dyspepsia. J Neurogastroenterol Motil, 2015. 21(1): p. 103-10.
Grover, M. and M. Camilleri, Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal diseases. J Gastroenterol, 2013. 48(2): p. 177-81.
Tack, J., et al., Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss. Clin Gastroenterol Hepatol, 2015.
Van Oudenhove, L., et al., Influence of buspirone on gastric sensorimotor function in man. Aliment Pharmacol Ther, 2008. 28(11-12): p. 1326-33.
Tack, J., et al., Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. Clin Gastroenterol Hepatol, 2012. 10(11): p. 1239-45.
Dinan, T. G., et al., A double-blind placebo-controlled study of buspirone-stimulated prolactin release in non-ulcer dyspepsia--are central serotoninergic responses enhanced? Aliment Pharmacol Ther, 2001. 15(10): p. 1613-8.
Bouchoucha, M., et al., Psychological profiles of irritable bowel syndrome subtypes., in Digestive Diseases Week. 2016, Gastroenterology: San Diego. p. S732.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
Copyright © 2013-, Open Science Publishers - All Rights Reserved