Weak Direct Current Stimulation: A New Prospect in William Syndrome Disorder with Regard to Social Fear
William’s syndrome is a multifaceted, unique syndrome, in which patients develop notable hypersociability and neurocognitive characteristics. In humans, transcranial direct current stimulation (tDCS) can enhance or diminish cortical excitability, which can modulate social cognition and behavior. The present knowledge suggests the involvement of dysfunctional neural circuitry and abnormal cortical excitability in neurodevelopmental disorder. The insight of tDCS to influence cortical excitability via membrane polarization constitutes a main breakthrough in our understanding of the changes in the brain states. In recent past, neuromodulatory effects of tDCS with regard to fear have been encouraged targeting the learning and memory processes. Nevertheless, until today tDCS studies with respect to fear and anxiety disorder has been very restricted. Consequently, in the near future, it will require special attention and further exploration. In this article author would like to suggest the potential of using tDCS to counter social fear in William’s syndrome.
Transcranial Direct Current Stimulation (tDCS), Neuropsychiatric Disorder, William’s Syndrome, Neuromodulation, Social Fear
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