Magnesium Valproic Acid Assisted with Compound Danshen Dripping Pills Repairs Abnormal Perfusion Foci in Children with Epilepsy
[1]
Wang Wei-min, Epilepsy Centre of No. 2 Hospital of Lanzhou University, Epilepsy Prevention and Treatment Center of Gansu Province, Lanzhou 730030, Gansu Province, China.
[2]
Fan Zhen-yu, Epilepsy Centre of No. 2 Hospital of Lanzhou University, Epilepsy Prevention and Treatment Center of Gansu Province, Lanzhou 730030, Gansu Province, China.
[3]
Zhang Yong-qin, Epilepsy Centre of No. 2 Hospital of Lanzhou University, Epilepsy Prevention and Treatment Center of Gansu Province, Lanzhou 730030, Gansu Province, China.
[4]
Wu Yin-ping, Epilepsy Centre of No. 2 Hospital of Lanzhou University, Epilepsy Prevention and Treatment Center of Gansu Province, Lanzhou 730030, Gansu Province, China.
[5]
Yang Yu-xia, Epilepsy Centre of No. 2 Hospital of Lanzhou University, Epilepsy Prevention and Treatment Center of Gansu Province, Lanzhou 730030, Gansu Province, China.
[6]
Ye Jiang, Epilepsy Centre of No. 2 Hospital of Lanzhou University, Epilepsy Prevention and Treatment Center of Gansu Province, Lanzhou 730030, Gansu Province, China.
Objective: To explore the repairing effect of Compound Danshen Dripping Pills with magnesium valproate sustained-release tablets on abnormal perfusion foci in epileptic children. Methods: After epileptic onset was controlled, abnormal perfusion foci in children were repaired using Compound Danshen Dripping Pills. The effectiveness of the treatment was evaluated with interictal SPECT, long-term video-EEG, and CT/MRI. Therapeutic drug monitoring was performed before and after treatment. Results: There were 79 boys and 31 girls. Generalized epilepsy was found in 62 cases and focal epilepsy in 48. Epileptic seizures were controlled for an average of 30.2 months. SPECT abnormalities were present in 85 cases (77.3%) before treatment with Compound Danshen Dripping Pills and significantly reduced to 39 cases (35.5%) afterward (P = 0.00). The number of abnormal perfusion foci decreased from 129 before treatment to 56 afterward. Conclusions: Compound Danshen Dripping Pills combined with magnesium valproate is an ideal treatment strategy for epilepsy in children because of the high degree to which abnormal perfusion foci are restored to normal.
Children with Epilepsy, Compound Danshen Dripping Pills, Magnesium Valproate, Repair, Abnormal Perfusion Foci, Interictal SPECT, Long-Term Video-EEG
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