Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Association Between Age and Body Mass Index on Bone Minerals in Postmenopausal Women
Current Issue
Volume 6, 2019
Issue 1 (March)
Pages: 19-23   |   Vol. 6, No. 1, March 2019   |   Follow on         
Paper in PDF Downloads: 14   Since Apr. 9, 2019 Views: 933   Since Apr. 9, 2019
Authors
[1]
Ebomoyi Maureen Isoken, Basic/Allied Medical Sciences, College of Medical Sciences, Edo University, Iyamho, Nigeria.
[2]
Ekhator Clement Nosa, Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria.
Abstract
Our recent study shows that postmenopausal women present with lower serum calcium but higher phosphate compared to premenopausal women and that this may contribute to their increased risk for osteoporosis. However, several factors such as genetic, hormonal and environmental factors had been implicated with paucity of information on the effect of age and body mass index. It is the objective of this study to determine the association between age and body mass index on serum calcium and phosphate activities in postmenopausal women. The study was a cross sectional study carried out in a catholic mission hospital in Benin City, Nigeria. A total of 40 pre-menopausal and 280 post postmenopausal women completed the study. Following standard ethical process and laboratory procedures blood sample was obtained from each woman for estimation of serum calcium and phosphate concentrations. Statistical analysis was done using SPSS version 20 at 95% confidence interval. There was a significant different in the age and the findings on BMI implies that postmenopausal women are 8.75 times more likely to be overweight. In the postmenopausal women, serum calcium correlates negatively with age (r = -0.064; p>0.05) and BMI (r=-0.055; p>0.05) while serum phosphate correlates positively with age (r = 0.077; p>0.05) and BMI (r = 0.131; p<0.05). The implications of these findings are that menopausal women may improve bone health by increase intake of calcium rich diet and increasing effort to reduced excessive weight gain.
Keywords
Menopausal Age, Body Mass Index, Postmenopausal, Bone Minerals
Reference
[1]
Peck W. A., Burckhardt P., Christiansen C., Fleisch H. A., Genant H. K., Gennari C., Martin T. J., Martini L., Morita R., Ogata E., Rapado A., Shulman L. E., Stern P. H., Young R. T. (1993). Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med.; 94: 646–650.
[2]
Hingorjo, M. R., SyedS. Qureshi M. A. (2008). Role of exercise in osteoporosis prevention. JAMA. 58: 51-101.
[3]
Svedbom A., E. Hernlund, M. Ivergård, J. Compston, C. Cooper, J. Stenmark, et al. (2013). EU review panel of IOF osteoporosis in the European Union: a compendium of country-specific reports. Arch Osteoporos, 8, p. 137.
[4]
Mithal A, Bansal B, Kyer CS, Ebeling P. (2014). The Asia-pacific regional audit-epidemiology, costs, and burden of osteoporosis in India 2013: a report of international osteoporosis foundation. Indian J Endocrinol Metab.; 18: 449–454.
[5]
Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA. (2013). Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA) Arch Osteoporos; 8: 136.
[6]
Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. (2007). Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res.; 22: 465–475.
[7]
Riggs B. L., Khosla S., Melton L. J. (2002). Sex steroids and the construction and conservation of the adult skeleton. Endocr. Rev.; 23: 279-302.
[8]
Liu Y. J., Zhang L., Papasian C. J., Deng H. W. (2014). Genome-wide association studies for osteoporosis: a 2013 update. J Bone Metab, 21, pp. 99-116.
[9]
Nachtigall M. J., Nazem T. G., Nachtigall R. H., Goldstein S. R. (2013). Osteoporosis risk factors and early life-style modifications to decrease disease burden in women. Clin Obstet Gynecol, 56, pp. 650-653.
[10]
Hosie C. J., Hart D. M., Smith D. A. (1989). Differential effect of long-term oestrogen therapy on trabecular and cortical bone. Maturitas, 11, pp. 137-145.
[11]
Kalkwarf H. J., Specker, B. L. (2002). Bone mineral changes during pregnancy and lactation. Endocrine; 17: 49-53.
[12]
World Medical Association (WMA) (2000). World Medical Association Declaration of Helsinki ethical principles for medical research involving human subjects. 2000.
[13]
Joseph C (1988). Statistical Power Analysis For The Behavioral Sciences. Lawrence Erlbaum Associates, Publishers, New Jersy. Second edition, page 1-6.
[14]
Tietz N. W. (1996). Fundamentals of clinical chemistry, 4 (Ed) W. B. saunders, Philadelphia. 917.
[15]
Daly J. A. Ertingshansen, G. (1972). Clinical Chemistry, 18-263.
[16]
Shakoor S, Ilyas F, Abbas N, Mirza AM. And Arif S. (2014). Prevalence of osteoporosis in relation to serum calcium and phosphorus in aging women. J. Glob. Innov. Agric. Soc. Sci., 2 (2): 70-75.
[17]
Susanto LTM (2011) Serum Osteocalcin and bone mineral density in postmenopausal women. Universa Medicina 30: 155-161.
[18]
Lane NE. (2006). Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol.; 194: S3–S11.
[19]
Mora, S. and V. Gilsanz. (2003). Establishment of peak bone mass. Endocrinol. Metab. Clin. North Am.; 32: 39-63.
[20]
Hannan, M. T., Felson D. T., Hughes D, Tucker K. L., Cupples L. A. and Wilson P. W. (2002). Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J. Bone Miner. Res.; 15: 710-20.
[21]
Khatake, P. D., JadhavS. S. and Afroz S. (2013). Relation between serum calcium level, bone mineral density and blood pressure in postmenopausal women. J. Rec. Trends Sci. Tech.; 7: 86-88.
[22]
Gallagher, J. C., Riggs B. L., Eisman J, Hamstra A, Arnaud S. B. and Hector. F. (1979). Intestinal calciumabsorption and serum vitamin D metabolites in normal subjects and osteoporotic patients. J. Clin. Invest.; 64: 729-736.
[23]
Hendrijantini N, Alie R, Setiawati R, Astuti ER. And Wardhana MP (2016) The Correlation of Bone Mineral Density (BMD), Body Mass Index (BMI) and Osteocalcin in Postmenopausal Women. Biol Med (Aligarh); 8: 319.
[24]
Hsu Y. H., Venners S. A., Terwedow H. A., Feng Y, Niu T, Laird N, Brain J. D., Cummings S. R., Bouxseinand M. L. and Rosen C. J. (2006). Relation of body composition, fat mass and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am. J. Clin. Nutr.; 83: 146-154.
[25]
Asomaning, K., Bertone-Johnson, E. R., Nasca P. C., Hooven F. and Pekow P. S. (2006). Association between body mass index and osteoporosis in patients referred for a bone mineral density examination. J. Women's Health.; 15: 1028-1034.
[26]
Zhao L. J., Liu Y. J., Liu P. Y., Hamilton J., Recker R. R. and Deng H. W. (2007). Relationship of obesity with osteoporosis. J. Clin. Endocrinol. Metab.; 92: 1640-1646.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
CONTACT US
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
E-mail:
LET'S GET IN TOUCH
Name
E-mail
Subject
Message
SEND MASSAGE
Copyright © 2013-, Open Science Publishers - All Rights Reserved