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Comparative Gastrointestinal Transit Rates in the Different Trimesters of Pregnancy in Wistar Rats
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Volume 3, 2016
Issue 3 (June)
Pages: 11-15   |   Vol. 3, No. 3, June 2016   |   Follow on         
Paper in PDF Downloads: 48   Since May 21, 2016 Views: 1537   Since May 21, 2016
Otamere H. O., Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.
Ojieh A. E., Department of physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.
Onyesom I., Department of physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.
Aloamaka C. P., Department of physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.
Pregnancy hormones are implicated in gastrointestinal functions, however studies results varies and in some instances contradictory. This study investigates the influence of different trimester of pregnancy on the rate of gastric emptying and small intestinal motility. The study involved twenty-four (24) adult rats weighing between 180g and 200g assigned to four (4) groups. Group 1 served as non-pregnant control while groups II, III and IV were rats in their first, second and third trimesters of pregnancy respectively. At the end of each trimester, rats were scarified and the stomach and intestine obtained for studies on gastric emptying and small intestinal motility rates following standard laboratory procedures. The results showed a significantly increase (P<0.05) in quantity of food eaten in the first trimester (4.40±1.13) but a non significant differences in rate of gastric emptying between groups. On the other hand, percentage small intestinal transition and small intestinal transit rate were fastest in the first trimester compared to the second and third trimesters and control. This indicates therefore that pregnancy has effects on the rate of gastric emptying and intestinal motility.
Pregnancy Hormones, Gastric Emptying, Intestinal Transit
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