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Precipitating Factors of Hepatic Encephalopathy Among Sudanese Patients with Liver Cirrhosis
Current Issue
Volume 2, 2015
Issue 4 (August)
Pages: 63-67   |   Vol. 2, No. 4, August 2015   |   Follow on         
Paper in PDF Downloads: 17   Since Sep. 7, 2015 Views: 2220   Since Sep. 7, 2015
Authors
[1]
Siddig Omer Handady, Department of Obstetrical and Gynecology, Imperial Hospital, Khartoum, Sudan.
[2]
Maiada Abbas Ahmed, Department of Internal Medicine, Khartoum North hospital, Khartoum, Sudan.
[3]
Amira Abbas Fadl, Department of Internal Medicine, Alribat University Hospital, Khartoum, Sudan.
[4]
Awad Ali M. Alawad, Department of Surgery, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan.
Abstract
Background: Hepatic encephalopathy is a challenging complication of advanced liver disease causing significant morbidity and mortality worldwide. Objective: To determine the precipitating factors of hepatic encephalopathy (HE) in Sudanese patients with liver cirrhosis. Methodology: It was cross sectional study, descriptive, prospective and hospital based study, conducted at Khartoum state hospitals in Sudan over a period of six months from November 2013 to April 2014. One hundred and twenty (n=120) adults, diagnosed cases of liver cirrhosis were included in this study. Results: Ninety one (n= 91, 75.8%) were male and twenty nine (29, 24.2 %) were females. The mean age was 50.23 years with STD ± 16.2. The common precipitating factors identified in this study were as follows, (n= 50,) (41.7%) had infection (n= 43,) (36.4%) had constipation, (n=33, 27.5%) had hypokalemia, (n=32, 26.7%) had hematemesis and Melina, (n=26, 21.7%) had hyponatremia, hepato-renal syndrome, hepatocellular carcinoma and recent excessive paracentesis were seen in (21.7%), (13.3%) and (11.7%) of patients respectively. Conclusion: This study concluded that most common precipitating factors of hepatic encephalopathy in our patients are infection, constipation electrolyte imbalance and upper gastrointestinal bleeding. These are potentially preventable and reversible.
Keywords
Liver Cirrhosis, Hepatic Encephalopathy, Precipitating Factors
Reference
[1]
Romero-Gómez M, Boza F, García-Valdecasas MS, et al. Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy. Am J Gastroenterol 2001; 96: 2718.
[2]
Joseph F. Perz, Gregory L. Armstrong, Leigh A. Farrington, Yvan J.F. Hutin, Beth P. Bell: The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer Worldwide: journal of hepatology Volume 45, October 2006, Pages 529–538.
[3]
Poordad FF. The burden of hepatic encephalopathy. Aliment PharmacolTher2006; 25(1):3-9.
[4]
Mehboob F. Frequency of risk factors for hepatic encephalopathy in patients of chronic liver disease. Ann King Edward Med Coll. 2003; 9:29-30.
[5]
Alam. I, Razaullah, Haider I, Humayun M, Taqweem MA, Nisar M, Intikhab et al. Spectrum of precipitating factors for hepatic encephalopathy in liver disease. Pak J Med Res. 2005; 44:96-100.
[6]
AMH Elfaki. Aetiology, complications, and preventive measures of liver cirrhosis; Elobeid Hospital; West Sudan. Sudan Journal of Medical Sciences Vol. 3 (1) 2008: pp. 25-28.
[7]
Ryan JM, Shawcross DL (2011)."Hepatic encephalopathy". Medicine 39 (10): 617–620.
[8]
Rothenberg ME, Keeffe EB. Antibiotics in the management of hepatic encephalopathy: an evidence-based review. Rev Gastroenterol Disord 2005; 5: s26-35.
[9]
Haussinger, D. And G. kircheis, 2002. Hepatic encephalopathy. Schweiz Rundsch Med Prax., 91:957-63.
[10]
Maqsood S, Saleem A, Iqbal A, Butt JA. Precipitating factors for hepatic encephalopathy: experience at Pakistan institute of medical science Islamabad. J Ayub Med Coll Abbottabad 2006 Oct-Dec; 18(4):58-62.
[11]
Atif Sitwat Hayat, NailaShaikh, Farzana Memon. Identification of Precipitating Factors in Hepatic Encephalopathy Patient at Liatquat University Hospital Jamshoro. World Applied Sciences Journal 2010; 8(6):661-666.
[12]
Ahmed H, Masoodur Rehman, Saeedi I, Shah D. Factors precipitating hepatic encephalopathy in cirrhosis of liver. J Postgrad MedInst 2001; 15:91-7.
[13]
Akhtar Ali Baloch, Niaz Ahmed Shaikh, HariLal, Nasrullah Jakhrani, Muhammad Masroor. common precipitating factors of hepatic encephalopathy in patient of chronic liver disease at civil hospital Karachi. Medical channel 2010;16:520).
[14]
Intekhab Alam, Razaullah, Igbal Haider, M Humayun, M Amjad Taqweem Muhammed Nisar. Spectrumof precipitating factors of hepatic encephalopathy in patients with liver cirrhosis. Pakistan J. Med. Res. 2005;44:96.
[15]
Col. Dr. Manzar Zakaria, Dr. Mujeeb-Ur-Rehman Abid Butt , Dr. Syed Rizwan Hussain, Dr. Ghulam Farid Rana. hepatic encephalopathy; precipitating factors in patients with cirrhosis. Professional Med J Sep 2008; 15(3):375-379.
[16]
Bikha Ram Devrajani, Syed Zulfiquar Ali Shah, Tarachand Devrajani, Dileep Kumar. precipitating factors of hepatic encephalopathy at tertiary care hospital Jamshoro, Hyderabad. Original article 2009; 59:683.
[17]
CA Onyekwere, AO Ogbera, L Hameed. Chronic liver disease and hepatic encephalopathy: Clinical profile and outcomes. Original Article 2011; 14(2):181-185.
[18]
QIU-MING WANG, QING JI, ZHI-JUN DUAN, MING ZHANG, and QING-YONG CHANG, A study on the position and etiology of infection in cirrhotic patients: A potential precipitating factor contributing to hepatic encephalopathy. Exp Ther Med. Aug 2013; 6(2): 584–590.
[19]
Mumtaz K, Ahmed US, Abid S, Baig N, Hamid S, Jafri W. Precipitating factors and the outcome of hepatic encephalopathy in liver cirrhosis. J Coll Physicians Surg Pak. 2010 Aug; 20(8):514-8.
[20]
Mohammad Tariq, SaleemIqbal, Najiullah Khan, Rabia Basri. Precipitating Factors of Hepatic Encephalopathy. RMJ. 2009; 34(1): 95-97.
[21]
Yahia Z Gad. Precipitating factors of hepatic encephalopathy: An experience at Mansoura Specialized Medical Hospital, Egypt. Ann Trop Med Public Health 2012; 5:330-4.
[22]
Sheik N. Hassan, MD, John L. Townsend, MD, and Sadye B. Curry, MD, hepatic encephalopathy retrospective analysis journal of the national medical association 1982; 74 521.
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