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A Perspective on Interaction between Lipid and Branched Chain Amino Acids (BCAA) in Developing Insulin Resistance
Current Issue
Volume 1, 2014
Issue 1 (February)
Pages: 8-12   |   Vol. 1, No. 1, February 2014   |   Follow on         
Paper in PDF Downloads: 13   Since Aug. 28, 2015 Views: 1824   Since Aug. 28, 2015
Authors
[1]
Sheriff D. S , Department of Biochemistry, Faculty of Medicine, Benghazi University, Benghazi, Libya.
[2]
Younis, M. Y. G , Department of Biochemistry, Faculty of Medicine, Benghazi University, Benghazi, Libya.
[3]
Elshaari F. A , Department of Biochemistry, Faculty of Medicine, Benghazi University, Benghazi, Libya.
[4]
Negia Abdalla Mohamed , Department of Biochemistry, Faculty of Medicine, Benghazi University, Benghazi, Libya.
[5]
Hanan Issa Ali El Kuwaila , Department of Biochemistry, Faculty of Medicine, Benghazi University, Benghazi, Libya.
[6]
Sara Ali Sh. Abdalla , Department of Biochemistry, Faculty of Medicine, Benghazi University, Benghazi, Libya.
[7]
Rajea Elfaghi , Department of Biochemistry, Faculty of Medicine, Benghazi University, Benghazi, Libya.
Abstract
There is a reciprocal relationship between glucose and fatty acid oxidation. Over nutrition or obesity causes perturbation in this reciprocal metabolic interrelationship leading to “metabolic inflexibility” resulting in mitochondrial dysfunction causing insulin resistance. Excess fat intake in obesity results in an inhibition of fatty acid oxidation in the adipose tissue accompanied by increased BCAA catabolism in skeletal muscle. This results in an increase in the levels of acyl carnitines which impair insulin action. It is suggested that serum acyl carnitine levels could therefore be taken as markers of insulin resistance.
Keywords
Branched Chain Amino Acids(BCAA), Metabolic Inflexibility, Acyl Carnitines, Insulin Resistance (IR)
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