The Relationship Between Melasma and Disturbances in the Serum Level of Thyroid Hormones and Indices
[1]
Rezvan Talaee, Kashan University of Medical Science, Faculty of Medicine Department of Dermatology, Dermatology Lab, Beheshti Hospital, Kashan, Iran.
[2]
Iman Ghafarpasand, Kashan University of Medical Science, Faculty of Medicine Department of Dermatology, Dermatology Lab, Beheshti Hospital, Kashan, Iran.
[3]
Hamidreza Masror, McGill University, Faculty of Medicine, Department of Experimental Surgery, Jewish General Hospital, Montreal, Canada.
Introduction: Melasma is a relatively common skin disorder that primarily affects areas exposed to sunlight. The cause of melasma is not well understood yet. Few studies have been performed on the relationship of melasma and thyroid disorders. In this study, we have investigated the association between melasma and thyroid parameters. Material and Method: In this study, 102 patients with melasma, referred to dermatology clinic of Kashan Shahid Beheshti hospital, were enrolled and compared with 55 healthy controls. Patients with melasma were divided into two groups: melasma with a known cause and idiopathic melasma. Patient information such as age, sex, duration of disease, menstrual status, underlying disease, cause of melasma and its severity (MASI score) were recorded in a questionnaire. T3, T4, TSH, Anti TPO and Anti Thyroglobulin were measured in all participants using the Immuno-chemiluminescence method. The data was then analyzed using SPSS version 16. Results: Mean serum levels of T3 and T4 were similar in all three groups. The mean serum level of TSH, Anti TPO and Thyroglobulin antibodies in patients with melasma were higher than the control group, but there was no statistically significant difference. The frequency of abnormal TSH levels in patients with idiopathic melasma was significantly higher than the other two groups (p=0.012). Conclusion: In this study, it was found that abnormal levels of TSH are associated with a higher risk of developing melasma. Also, it was found that serum levels of TSH, anti TPO and anti-thyroglobulin are higher in patients with melasma.
Melasma, Thyroid gland, TSH, Anti TPO, Anti-Thyroglobulin
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