The Effect of Gestational Diabetes on Placental Weight in Sudanese: A Comparative Study
Gestational diabetes may cause some structural alterations of placenta. To find out the effect of gestational diabetes on placental weight in a singleton pregnancy, a case control study was conducted in Omdurman Maternity Hospital, Khartoum (January 2015-September 2017), after due approval from institutional research committee, Alzaeim Alazhari University. The subjects were mothers who delivered in the hospital. Cases were selected randomly, and divided in two groups: group B consisted of mothers having normal pregnancy, group A consisted of mothers whose pregnancies were complicated by gestational diabetes mellitus. The data was managed statistically by SPSS. A total of 385 placentae were collected, 128 were gestational diabetic placentae (Group A) and 257 were normal placentae (group B). The mean placental weight in group A was 660 ± 116 gm (range, 470–900), while it was less in group B as 545± 206 (range, 300–900), and the difference was significant (P-value < 0.021). In conclusion there is significant increase in the placental weight in gestational diabetes placentae.
Placenta, Gestational Diabetes Mellitus, Normal Pregnancy, Placental Weight, Parity, Body Mass Index
Matsuda Y, Ogawa M, Nakai A, Hayashi M, Satoh S, Matsubara S. Fetal/Placental Weight Ratio in Term Japanese Pregnancy: Its Difference Among Gender, Parity, and Infant Growth int J Med Sci., 2015; 12 (4):301-305.
Salih SHA., Omar AM. The relationship between the weight of the placenta and neonatal outcome. IOSR-JNHS., 2017; 6 (6):1-8.
Ohlsson A, Shah P. IHE REPORT. Placental factors. Determinant and prevention of LBW: a synopsis the evidence. Canada, Insitute of Health Economics Albert Canada, 2008.
Mahajan S, Aalinkeel R, Shah P, Singh S, Kochupillai N. Nutritional anemia dysregulates endocrine control of fetal growth. Br. J. Nutr., 2008, 100 (2):408–17.
Wallace JM, Bhattacharya S, Horgan GW. Gestational age, gender and parity specific centile charts for placental weight for singleton deliveries in Aberdeen, UK. Placenta, 2013; 30:269-274.
Hindmarsh PC, Geary MP, Rodeck CH, Jackson MR, Kingdom JC. Effect of early maternal iron stores on placental weight and structure. Lancet, 2000; 356 (9231):719-723.
Tetteh J. Gross morphometry of the human placenta and umbilical cord with reference to neonatal indices, Kumasi, Ghana (Master dissertation), 2015. Retrieved from http://ir.knust.edu.gh/bitstream/123456789/8751/1/JOSHUA%20TETTEH.pdf.
Kun A, Tornoczky J, Tabak AG. Prevalence and predictors of GDM in Hungary. Horm Metab Res., 2011; 43 (11):788–93.
Hayward C, Lean S, Sibley C, Jones R, Wareing M, Greenwood S, Dilworth M. Placental adaptation: What can we learn from birth weight: Placental weight ratio? Physiol., 2016; 7:1-13.
Desoye G, Myatt L. The placenta. In Diabetes in Women: Adolescence, Pregnancy, and Menopause. 3rd ed. Reece EA., Coustan DR., Gabbe SG. editors. Philadelphia, Lippincott Williams & Wilkins. 2004. pp. 147–57.
Desoye G, Hauguel-De Mouzon S. The human placenta in gestational diabetes mellitus: The insulin and cytokine network. Diabetes Care, 2007; 30 (2):S120-S126.
Sirpurkar M, Anjankar VP. Study of correlation between placental morphology and adverse perinatal outcome in different conditions affecting pregnancy. Int J Reprod Contracept Obstet Gynecol., 2015; 4:1165-8.
Roum EMS, Haavaldsen C, Tanbo TG, Eskild A. Paternal age, placental weight and placental to birth weight ratio: a population-based study of 590 835 pregnancies. Human Reproduction, 2013; 28 (11):3126–3133.
Asgharnia M, Esmailpour N, Poorghorban M, Atrkar-Roshan Z. Placental weight and its association with maternal and neonatal characteristics. Acta Medica Iranica, 2008; 46 (6):467-472.
Erbil N, Toprak N, Açıkgöz Ö, Gelen S, Arık N. The Relationship between Maternal, Placental and Newborn Parameters. Middle Black Sea Journal of Health Science, 2015; 1 (1):11-18.
Saini P, Pankaj JP, Jain A, Agarwal GC. Effect of gestational diabetes mellitus on gross morphology of placenta: A comparative study. Int J Anat Res., 2015; 3 (1):889-94.
Abdelghany AH, Eissa TM, Idris S. Study of the ultrastructure of the placenta in gestational Diabetes mellitus. Int J Anat Var., 2018; 11 (1):4-10.
Arshad R, Karim N, Hasan JA. Effects of insulin on placental, fetal and maternal outcomes in gestational diabetes mellitus. Pak J Med Sci., 2014; 30 (2):240-244.
Saha S, Biswas S, Mitra D, Adhikari A, Saha C. Histologic and morphometric study of human placenta in gestational diabetes mellitus. Italian journal of anatomy and embryology, 2014; 119 (1):1-9.
William PL, Wendell–smith CP, Treadgold S. 1969, Basic Human embryology, 2nd edition lippincolt: Philadelphia.
Boyd JD, Hamilton WJ. The Human placenta. Heffer; Cambridge. 1973; 8 (1):77-78.
Chung SO, Park KH. Clinical studies on Biometric of the Placenta. Yonsei Med J., 1974; 15: 92- 102.
Bhatnagar SM, Kotari ML, Lopa A. MAHETA. Essential of human embryology 2nd addition, 1983. pp 69-75.
Frisancho AR, Matos J, Bollettino LA. Influence of growth status and placental function on birth weight of infants born to young still-growing teenagers. Am J Clin Nutr., 1984; 40: 801-807.
Jaya DS, Kumar NS, Bai LS. Anthropometric indices, cord length and placental weight in newborns. Indian Pediatr., 1995; 32:1183-1188.
Tewari K, Tyagi SP, Saxena K, Usman F, Begum R. Ultrasonographic and histological study of placenta in abnormal pregnancy cases J. Obstetrics and Gynaecology Indian, 1997; 47 (1): 119-26.
Majumdar S, Dasgupta H, Bhattacharya K, Bhattacharya A. A study of placenta in normal and hypertensive pregnancies. J Anat Soc India, 2005; 54:1-9.
Susan S, Thomas I. Gray’s Anatomy – The Anatomical Basis of Clinical Practice. Implantation, Placentation, Pregnancy and Parturition. 39th Ed, London: Churchill Livingstone. 2005. Pp. 1341-1348.
Ashfaq M, Channa MA, Malik MA, Khan D. Morphological changes in human placenta of wet snuff users. J Ayub Med Coll Abbottabad, 2008; 20:110-113.
Appiah PK. Relationship between the morphology of the placenta, umbilical cord and perinatal outcome, Kumasi, Ghana (Master dissertation), 2009. Retrieved from ir.knust.edu.gh/bitstream/.../PETER%20KWABENA%20APPIAH.pdf.
Petekkaya E, Deniz M, Yildiz E. Analysis of the relationship between umbilical cord, placental morphology and anthropometric measurements of the newborn. Pak J Med Sci., 2011; 27 (3):569-573.
Raghunath G., Shenoy VV. Clinically relevant morphology and morphometry of Placenta. Journal of Clinical and Diagnostic Research, 2011; 5 (2):282-286.
Pei H. Developmental Biology of the Placenta. Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology, Current Clinical Pathology, DOI 10.1007/978-1-61779-394-3_2, © Springer Science+Business Media, LLC 2012.
Lakshmi devi CK, Neelam S, Raghupathy NS. Morphological studies of normal human placenta at different gestational periods. IOSR-JDMS., 2013; 6 (3):9-15.
Anjum A, Suseelamma D, Saritha S, Ramani TV, Jyothi DN. Study of morphological variations of 50 placentae with umbilical cords and its developmental relevance. Int J Anat Res 2015; 3 (3):1259-66.
Akhter F, Banu LA, Ferdausi R. Effect of gestational diabetes mellitus on gross morphological structure of preterm placenta. Bangladesh Journal of Anatomy, 2010; 8 (1):34-38.
Hussain SP, Islam ZA. Gestational diabetes: Effect on gross morphology of human placenta and birth weight. PJMHS., 2013; 7 (4):1077-1081.
Khaskhelli LB, Memon S, Goswami P, Bano S. Change in normal morphology of placenta and its possible effects on fetal outcome in diabetic mothers as compared to non-diabetic mothers. JLUMHS., 2013; 12 (1):49-54.
Jeelani H, Jabeen F, Qureshi A, Mushtaq S. Gross morphological alterations and birth weight in gestational diabetes mellitus: A case-control study. JK- Practitioner, 2015; 20 (1-2): 17-20.
Elshennawy TMA. Effect of gestational diabetes on gross morphology, histology and histochemistry of human placenta. Endocrinol Metab Syndr., 2016; 5: 227.
Sharmila BP, Devi SK, Sujatha K, Subhadra DV. Gross morphological study of gestational diabetes mellitus placenta from south Indian mothers compared with control placenta. Int J Anat Res., 2017; 5 (1):3521-26.
Balihallimath RL, Bhusaraddi PS, Singh I, Tyagi N. Determinants of feto-placental ratio. Journal of International Medicine and Dentistry, 2015; 2 (2): 111-117.