A Mathematical Model of Cancer Under Radiotherapy
[1]
Raul Isea, Institute of Advanced Studies – IDEA, Hoyo de la Puerta, Baruta, Venezuela.
[2]
Karl E. Lonngren, Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA.
The goal of this paper is to suggest a three mathematical model description of the Lotka-Volterra competition model type that could be used in understanding the action of radiation when the cancerous cells, the healthy cells and the cells that are triggered by the immune cells interact with each other. In order to do that, we analyze the model where there is only an interaction between the cancer and the normal cells. We extend the model to include immune response cells. Finally, we examine the effects of radiation therapy according to three different mathematical models.
Cancer, Lotka-Volterra, Cells, Dynamics, Radiotherapy
[1]
L. Hanin. (2011). Why Victory in the War on Cancer Remains Elusive: Biomedical Hypotheses and Mathematical Models. Cancers. 3, 340-367.
[2]
C. Letellier, F. Denis, L. A. Aguirre. (2013). What can be learned from a chaotic cancer model? Journal of Theoretical Biology 322, 7–16.
[3]
M. Saleem, Tanuja Agrawal. (2012). Chaos in a tumor growth model with delayed responses of the immune system. Journal of Applied Mathematics. Article ID 891095.
[4]
M. C. Galindo. (2014). Hopf bifurcation cascade through large e of period-doubling, chaos, and the possibility of cure in a 3D cancer model. Abstract and Applied Analysis, 1-11.
[5]
Z. Liu, C. Yang. (2014). A mathematical model of cancer computational and mathematical methods in medicine. Vol 2014, article id 17293, 1-12.
[6]
R. P. Jiménez, E. O. Hernández. (2011). Tumor-host dynamics under radiotherapy. Chaos, Solitons & Fractals. 44, 685-692.
[7]
M. Gilpin (1979). Spiral chaos in a predator model. The Am. Nat. 113, 306-308.
[8]
A. Arneodo, P. Coullet, J. Peyraud, C. Tresser. Strange attractors in volterra equations for species in competition. Journal of Mathematical Biology (1982) 14, pp 153-157.
[9]
F. J. Blanco-Silva. Learning SciPy for Numerical and Scientific Computing. Birmingham, U. K.: Packt Publishing; 2013.
[10]
G. Belostoski. A Control theory model for cancer treatment by radiotherapy. MSc. Thesis. University Alberta (2004).