Clinical Value of the Changes of ER, PR, HER2 and Ki-67 Expressions Before and After Neoadjuvant Chemotherapy in Breast Cancer
Objective: To investigate clinical value of the changes of ER, PR, HER2 and Ki-67 expressions before and after neoadjuvant chemotherapy in breast cancer. Methods: From January 2011 to December 2016, the clinical data of 72 patients with locally advanced breast cancer, which received neoadjuvant chemotherapy were collected. The relationship between curative effect of neoadjuvant chemotherapy and clinical feature, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor-2 (HER2), and Ki-67 were analyzed retrospectively. Results: In the 72 cases of breast cancer, the total effective rate of neoadjuvant chemotherapy was 76.4% (55/72). Among them, CR, PR an SD were 16.7% (12/72), 59.7% (43/72) and 23.6% (17/72) respectively. No progressed case was found. Pathological complete remission (pCR) was in 9.72% (7/72). There were significant relationships between the clinical effective rate of neoadjuvant chemotherapy and the size of primary tumor, ER, PR, HER 2 and Ki-67 (P<0.05). Pathological complete remission was correlated with the status of ER, and PR (P<0.05). The changes of ER, PR, HER2 and Ki-67 were in 22.2%, 25.0%, 15.3% and 55.6% respectively before and after between neoadjuvant chemotherapy in breast cancer. There were significant correlation between the curative effect of neoadjuvant chemotherapy and changes of ER, PR, Ki-67 (P<0.05). There were no significant correlation between HER2 and curative effect of neoadjuvant chemotherapy. Conclusion: The ER, PR, HER2 and Ki-67 expressions show significant changes after neoadjuvant chemotherapy in breast cancer. ER, PR and Ki-67 would predict the curative effects of neoadjuvant chemotherapy.
Breast Cancer, Neoadjuvant Chemotherapy, Curative Effect
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