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Cardiovascular and Other Risk Factors Among Kwame Nkrumah University of Science and Technology Students
Current Issue
Volume 5, 2017
Issue 6 (December)
Pages: 35-42   |   Vol. 5, No. 6, December 2017   |   Follow on         
Paper in PDF Downloads: 38   Since Dec. 20, 2017 Views: 513   Since Dec. 20, 2017
Authors
[1]
Patricia Kwakai Brown, Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
[2]
Sandra Asomaniwaa Boamah, Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
[3]
Emefa Abena Ashiadey, Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
[4]
Bernard Cudjoe Nkum, Department of Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
[5]
Frank Botsi Micah, Department of Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Abstract
Cardiovascular diseases (CVD) risk factors can be classified as non-modifiable risk factors such as age and a family history of premature CVD and modifiable risk factors including hypertension, obesity, smoking, dyslipidaemia, diabetes mellitus (DM), excessive alcohol consumption, physical inactivity and unhealthy dietary habits, including low consumption of vegetable and fruits. The aim of this study was to determine the prevalence of cardiovascular and other risk factors as well as the association between these risk factors among students of Kwame Nkrumah University of Science and Technology. This cross sectional study enrolled 100 apparently healthy students aged 19 and 25 years. A questionnaire was filled and anthropometric measurements were taken. Fasting blood glucose, urea, creatinine, uric acid, total cholesterol (TC), high density lipoprotein cholesterol (HDL) and triglycerides (TG) were determined on venous blood samples. The level of low-density lipoprotein cholesterol (LDL) was calculated using the Friedwald formula. The estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration equation. Family history of DM (24.0%) and hypertension (21.0%) were common. The prevalence of alcohol consumption was 7%, high waist-hip ratio 6%, BMI  30 3%, hypertension 9%, DM 3%, impaired fasting glucose 4%, high TC 37%, high LDL 15%, low HDL 1% and hyperuricaemia 9%. Only one female had eGFR 30 – 59, 17% had eGFR 60 – 89 while 82% had eGFR > 90. None of the students had ever smoked and there were no cases of high TG and high waist circumference. There were clustering of these risk factors with 74 participants having at least one of these risk factors and 26 with no risk factor. These risk factors were therefore common among these students and there is the need for more frequent assessment. Pharmacological and non-pharmacological treatment may be necessary for some of these conditions.
Keywords
Risk Factors, CVD, Cardiovascular, Hypertension, DM
Reference
[1]
World Health Organization. World Health Report 2003 – Global Strategy on Diet, Physical Activity and Health. Geneva, Switzerland: World Health Organization, 2003.
[2]
Forrester T, Cooper RS, Weatherall D. Emergence of Western diseases in tropical worlds: the experience with chronic cardiovascular diseases. Br Med Bull. 1998; 54 (2): 463-473.
[3]
Kadiri S. Tackling cardiovascular disease in Africa. BMJ, 2005; 331: 711-712.
[4]
Plange-Rhule J, Phillips R, Acheampong JW, Saggar-Malik AK, Cappuccio FP, Eastwood JB. Hypertension and renal failure in Kumasi, Ghana Journal of Human Hypertension (1999) 13, 37–40.
[5]
Akinkugbe FM, Akinwolere AO, Kayode CM. Blood pressure patterns in Nigerian adolescents. West Afr J Med. 1999 Jul-Sep; 18 (3): 196-202.
[6]
Cooper RS, Amoah AG, Mensah GA High blood pressure: the foundation for epidemic cardiovascular disease in African populations. Ethn Dis. 2003 Summer; 13 (2 Suppl 2): S48-S52.
[7]
Cooper RS, Rotimi C. Establishing the epidemiologic basis for prevention of cardiovascular diseases in Africa. Ethn Dis. 1993; 3: S13–S22.
[8]
Cappuccio FP, Micah FB, Emmett L, Kerry SM, Antwi S, Martin-Peprah R, Phillips RO, Plange-Rhule J, Eastwood JB. Prevalence, detection, management, and control of hypertension in Ashanti, West Africa. Hypertension. 2004 May; 43 (5): 1017-1022.
[9]
Bosu WK. Epidemic of hypertension in Ghana: a systematic review. BMC Public Health 2010; 10: 418.
[10]
Hill AG, Darko R, Seffah J, Adanu RMK, Anarfi JK, Duda RB. Health of urban Ghanaian women as identified by the Women‟s Health Study of Accra. Int J Gyn Obstet 2007; 99: 150-156.
[11]
Owiredu WKBA, Adamu MS, Amidu N, Woode E, Bam V, Plange-Rhule J, Opoku-Okrah C. Obesity and Cardiovascular Risk Factors in a Pentecostal Population in Kumasi-Ghana. J Med Sci 2008; 8: 682-690.
[12]
Ghana Statistical Service (GSS), Ghana Health Service (GHS), ICF Macro. Ghana Demographic and Health Survey 2008. Accra, Ghana: GSS, GHS and ICF Macro; 2009.
[13]
Naicker S. End-stage renal disease in sub-Saharan and South Africa. Kidney Int Suppl 2003; 83: S119-S122.
[14]
Mate-Kole MO, Affram RK. Presentation and clinical course of End-stage renal failure in Ghana. A preliminary prospective study. Ghana Med. J 1990; 24: 164-168.
[15]
Haroun MK, Jaar BG, Hoffman SC, et al. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol 2003; 14: 2934–2941.
[16]
Mate-Kole M. (2007). Chronic haemodialysis and its impact on national economy. Paper presented at the launching of the National Kidney Foundation-Ghana (NAKID-G), at the Kole-Bu Teaching Hospital, Accra, Ghana.
[17]
Osafo C., Mate-Kole M., Affram K., Adu D (2011). Prevalence of Chronic Kidney Disease in hypertensive patients in Ghana. Renal Failure, 33 (4), 388-392.
[18]
Wang S, Shu Z, Tao Q, Yu C, Zhan S, Li L. Uric acid and incident chronic kidney disease in a large health check-up population in Taiwan. Nephrology (Carlton). 2011 Nov; 16 (8): 767-76.
[19]
See LC, Kuo CF, Chuang FH, Li HY, Chen YM, Chen HW, Yu KH. Serum uric acid is independently associated with metabolic syndrome in subjects with and without a low estimated glomerular filtration rate. J Rheumatol. 2009 Aug; 36 (8): 1691-8. doi: 10.3899/jrheum.081199. Epub 2009 Jun 16.
[20]
Micah FB, Nkum BC, Yeboah FA, Timmy-Donkor E. Factors Associated with Hyperuricaemia in a Tertiary Care Center in Ghana. International Journal of Applied Science and Technology. October 2015 Vol. 5, No. 5.
[21]
Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force Consensus Group. The metabolic syndrome a new worldwide definition. Lancet 2005; 366: 1059-62.
[22]
Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006 May; 23 (5): 469-80.
[23]
Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, LakkaTA: Metabolic syndrome and development of diabetes mellitus: Application and validation of recently suggested definitions of metabolic syndrome in a prospective cohort study. AM J Epidemiol 156: 1070-1077, 2002.
[24]
Saad MF, Rewers M, Selby J, Howard G, Jinagouda S, Fahmi S, Zaccaro D, Bergman RN, Savage PJ, Haffner SM: Insulin resistance and hypertension. Hypertension 43: 1324–1331, 2004.
[25]
NCD Control Programme. Ghana STEPS Survey Fact Sheet: Greater Accra Region 2006. Accra: GHS; 2010.
[26]
Friedwald WI, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972; 18: 499-502.
[27]
Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. L., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T. and Coresh, J. (2009). A new equation to estimate glomerular filtration rate. Annals of Internal Medicine, 150 (9), 604-612.
[28]
Chalmers J, MacMahon S, Mancia G, Whitworth J, Beilin L, Hansson L et al. 1999 World Health Organization-International Society of Hypertension Guidelines for the management of hypertension. Guidelines sub-committee of the World Health Organization. Clin Exp Hypertens. 1999 Jul-Aug; 21 (5-6): 1009-60.
[29]
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health. Obes Res. 1998; 6 Suppl 2: 51S-209S.
[30]
Alberti KG, Zimmet PZ. Definition, diagnosis, and classification of diabetes mellitus and its complica-tion Part 1: diagnosis and classification of diabetes mellitus: provisional report of a WHO consultation. Diabetes Med 1998; 15: 539-553.
[31]
World Health Organisation. Definition and diagnosis diabetes mellitus and intermediate hyperglycaemia: Report of a WHO/IDF Consultation, Geneva, Switzerland. 2006.
[32]
Executive summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97.
[33]
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation, 2002, 106: 3143-3421.
[34]
Harmonisation of Reference Intervals Pathology Harmony Group, Clinical Biochemistry Outcomes, January 2011. Retrieved 24 March 2017.
[35]
Owusu A. Global School-Based Student Health Survey (GSHS) 2008: Ghana Report Senior High Schools: Middle Tennesse State University, WHO, CDC, GES; 2008.
[36]
Antwi DA, Tete-Donkor D, Clottey MK. A study of physical activity and plasma cholesterol in Ghanaian males using a single question. Ghana Med J. 2001; 35: 33-37.
[37]
Asibey-Berko E, Avorkliyah VMA. Serum cholesterol levels of male blood donors at Korle-Bu Teaching Hospital. Ghana Med J. 1999; 33: 104-107.
[38]
Bonakdaran S, Hami M, Shakeri MT. Hyperuricemia and albuminuria in patients with type 2 diabetes mellitus. Iran J Kidney Dis. 2011 Jan; 5 (1): 21-4.
[39]
Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M, Truong L, Harris R, Johnson RJ. A role for uric acid in the progression of renal disease. J Am Soc Nephrol. 2002 Dec; 13 (12): 2888-97.
[40]
Liu, B., Wang, T., Zhao, H., Yue, W., Yu, H., Liu, C., Yin, J. R. and Nie, H. (2011). The prevalence of hyperuricaemia in China: a meta-analysis. Biomed Central Public Health 11: 832.
[41]
Vitoon, J, Rungroj, K., Thananya, B., Kamol, U. and Suthipo, U. (2008). Prevalence of Hyperuricaemia in Thai patients with acute coronary syndrome. Thai Heart Journal 21: 86-92.
[42]
Hovind P, Rossing P, Johnson RJ, Parving HH. Serum uric acid as a new player in the development of diabetic nephropathy. J Ren Nutr. 2011 Jan; 21 (1): 124-7. doi: 10.1053/j.jrn.2010.10.024.
[43]
Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003 Jun; 41 (6): 1183-90. Epub 2003 Apr 21.
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