Assessment of Sedative and Analgesic Effects of Xylazine and Acepromazine in Dog
Israrul Haq, Department of Animal Surgery and Obstetrics, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam, Pakistan.
Yasir Ali, Department of Animal Surgery and Obstetrics, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University Tandojam, Pakistan.
To investigate the comparative effect of xylazine and acepromazine for sedation in dogs, experiment was performed at Sind Agriculture University, Tandojam. Pre-treatment observations on body temperature, respiratory rate and pulse rate were recorded and later these observations were recorded after 5, 15, 25, 35, 45 and 55 min after sedation. All animals (n=10) kept in an experiment were examined for salivation, urination, head dropping, staggering, ped reflexes, eye reflexes, tongue profusion and vomiting. The results showed that the body temperature after 5, 15, 25, 35, 45 and 55 min of sedation with xylazine was 102.6, 102.3, 102.1, 102.3, 102.4 and 102.5°F, against pre-treatment of 102.9°F averaging 102.4°F. While, in acepromazine sedated dogs the body temperature was 102.7, 102.4, 102.2, 102.0, 102.3, and 102.8°F, respectively against pre-treatment of 103.0°F averaging 102.5°F. Mean respiratory rate after prescribed minutes of sedation with xylazine was 20.0, 17.4, 16.4, 18.6, 19.8 and 19.6, against pre-treat value of 18.57 averaging 19.1 breaths/min. While in acepromazine sedated dogs, the respiratory rate was 20.4, 18.4, 19.6, 19.0, 19.6 and 21.4, against pre-treat value of 20.2 averaging 20.2 breaths/min. The pre-treatment mean (control) values for pulse rate were 78.8 and 83.0 beats per minutes in dogs treated with xylazine and acepromazine, respectively. The onset of sedation in dogs treated with xylazine was 103 seconds, and in anacepromazine, the average onset of sedation was 130 seconds. On average, total duration of sedation in dogs sedated by xylazine was 65.4 min and in acepromazine, 39.8 min were observed. It was noted that in deep sedation salivation, urination, head dropping, staggering, ped reflexes, eye reflexes, tongue profusion and vomiting generally occurs in both groups, which proved that xylazine produced deep sedation, while acepromazine produced moderate sedative.
Acepromazine, Eye Reflexes, Sedation, Xylazine
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