Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News Unsubscribe Page
Traditional Chinese Medicine Combined with Western Medicine for the Treatment of Early Hippocampal Sclerosis in Patients with Epilepsy
Current Issue
Volume 5, 2017
Issue 1 (February)
Pages: 1-8   |   Vol. 5, No. 1, February 2017   |   Follow on         
Paper in PDF Downloads: 14   Since Jun. 7, 2017 Views: 235   Since Jun. 7, 2017
Authors
[1]
Wei-min Wang, Department of Epilepsy, Second Hospital of Lanzhou University, Lanzhou, China.
[2]
Zhen-yu Fan, Department of Epilepsy, Second Hospital of Lanzhou University, Lanzhou, China.
Abstract
Objective: To block the disease progression from FS to HS to TLE, control GTCS immediately after or in the early stage of febrile seizure, and repair HS (functional change) in patients with early epilepsy onset are the key to repair of mild HS injury. We proposed traditional Chinese medicine combined with western medicine for the treatment (neuroprotectant combined with cocktail) of HS (functional change) in patients with early epilepsy onset as confirmed by abnormal MRS findings. Methods: Thirty patients with epilepsy who received treatment between 2012 and 2013, consisting of 16 males and 14 females, aged 5-34 years, were included in this study. All of them underwent pre-and post-treatment MRI, MRS and inter-ictal brain SPECT imaging, V-EEG monitoring. AEDs together with neuroprotectant combined with cocktail were used for 10 days. Serum AEDs level was monitored. The N-acetylaspartate (NAA)/ (creatine (Cr) and choline (Cho)) value was calculated. All patients were followed up for 2 weeks to 1 year. Results: As per the types of epileptic seizure, GTCS in 17 patients, TLE in 10 patients and other types of seizure in 3 patients. Epileptic seizure was controlled for an average of 37.6 months in 20 (66.7%) patients and it was not controlled in 10 patients (33.3%). Prior to treatment, MRI normalities were in 18 (60%) patients and abnormal MRI findings in 12 (40%) patients. MRS abnormalities were all 30 (100%) patients, with NAA/(Cr+Cho) value < 0.68 (average 0.60±0.03 (range 0.53-0.66), indicative of early HS in epilepsy onset. After treatment, MRS normalities were 16 (53.33%) patients, and NAA/(Cr+Cho) value (> 0.7) recovered to normal in these 16 patients, and there was significant difference between prior to and after treatments (P <0.05). After treatment, MRI normalities were 16 patients and abnormal MRI findings in 14 patients. There were two patients who showed MRI normalities prior to treatment but abnormal findings after treatment: reduced hippocampal volume, increased signal intensity, enlarged temporal horns, and further decreased NAA/(Cr+Cho) value. Conclusion: Sixteen out of 30 epilepsy patients presenting with HS (functional change) had normal MRS findings (53.33%) after treatment of neuroprotectant combined with cocktail. These results indicate that mild HS can be partially reversed, and the combined therapy provides a new therapy for blocking the progression of TLE from GTCS. and reduced drug-fast TLE and For a third group TLE accounted for epilepsy group (5000 ten thousand) of has strategic significance.
Keywords
Epilepsy, Repair, Neuroprotectant Combined with Cocktail, Mild HS, Functional Change, NAA/(Cr+Cho) Value
Reference
[1]
Baron R, Ferriero DM, Frisoni GB, Bettegowda C, Gokaslan ZL, Kessler JA, Vezzani A, Waxman SG, Jarius S, Wildemann B, Weller M. Neurology--the next 10 years. Nat Rev Neurol. 2015;11(11):658-664.
[2]
Jiang CC, Yu LY, Hong Z. Temporal lobe epilepsy. Shanghai: Fudan University Press, 2003: 67.
[3]
Jackson GD, Chambers BR, Berkovic SF. Hippocampal sclerosis: development in adult life. Dev Neurosci. 1999;21(3-5):207-214.
[4]
Lin Y, Rao HB, Wu RH. 1H-MRS quantitatively measures brain metabolites. Guowai Yixue (Fangshe Yixue Heyixue Fence). 2005;29(2):85-88.
[5]
Connelly A, Jackson GD, Duncan JS, King MD, Gadian DG. Magnetic resonance spectroscopy in temporal lobe epilepsy. Neurology. 1994;44(8):1411-1417.
[6]
Chen XJ, Xu LZ, Lu SQ. Magnetic resonance spectroscopy and magnetic resonance imaging in diagnosis of temporal lobe epilepsy. Suzhou Daxue Xuebao Yixueban.2006;26(4):653-656.
[7]
Achten E, Boon P, Van De Kerckhove T, Caemaert J, De Reuck J, Kunnen M. Value of single-voxel proton MR spectroscopy in temporal lobe epilepsy. AJNR Am J Neuroradiol. 1997;18(6):1131-1139.
[8]
Park SA, Kim GS, Lee SK, Lim SR, Heo K, Park SC, Chang JW, Kim DI, Lee BI. Interictal epileptiform discharges relate to 1H-MRS-detected metabolic abnormalities in mesial temporal lobe epilepsy. Epilepsia. 2002;43(11):1385-1389.
[9]
Rowe CC, Berkovic SF, Austin MC, Saling M, Kalnins RM, McKay WJ, Bladin PF. Visual and quantitative analysis of interictal SPECT with technetium-99m-HMPAO in temporal lobe epilepsy. J Nucl Med. 1991;32(9):1688-1694.
[10]
Andersen AR, a Rogvi-Hansen B, Dam M. Utility of interictal SPECT of rCBF for focal diagnosis of the epileptogenic zone(s). Acta Neurol Scand Suppl. 1994;152:129-134.
[11]
Wang WM, Wang T, Ye J, zhao L, zhang H. Dynamic changes of the abnormal cerebral perfusion focus in patients with epilepsy before and after short -term cocktail treatment. 7th Asian Oceanian Epilepsy Congress. 2008: P274.
[12]
Wei-min Wang, Yong-qin Zhang, Ying-ping Wu, Zhen-yu Fan, Yu-xia Yang, Jiang Ye Repaired abnormal perfusion foci in children with epilepsy through traditional Chinese medicine compound Danshen Dripping pills assisted with valproic acid(110case): to evaluate in a new treating in interictcal SPECT and long-term V-EEG and imaging. 30th International Epilepsy Congress, 2013: 177.
[13]
Wei-min Wang, Yong-qin Zhang, Ying-ping Wu, Zhen-yu Fan, Yu-xia Yang, Jiang Ye. Magnesium Valproic acid assisted with Compound Danshen Dripping pills repairs abnormal perfusion foci in children with epilepsy. Medicine Journal. 2014;1(3):26-33.
[14]
Wang WM, Zhao SY, Liu YQ. Repair of abnormal perfusion foci in idiopathic epilepsy patients under long-term antiepileptic treatment. Neural Regen Res. 2011;6(2):155-160.
[15]
Wang WM, Song WJ, Dang XL. Dynamic model changes of three interictal spect of epilepsy patients with long-term control with AEDs and its clinical significance (63 cases). Epilepsia. 2011; 52(Suppl.6):207.
[16]
Wang W, Fan Z, Zhang Y, Yang Y, Liu Y, Dang X, Song W, Wu Y, Ye J. Tall gastrodis tuber combined with antiepileptic drugs repairs abnormal perfusion foci in focal epilepsy. Neural Regen Res. 2013;8(3):208-217.
[17]
Wang WM, Wang TC, Chen XH, Feng ZP, Ye J, Luo FM. Dynamic changes of abnormal perfusion foci on SPECT in patients with epilepsy before and after long-term control of epilepsy with antiepileptic drugs. Guoji Shenjingbingxue Shenjing Waikexue Zazhi. 2009;36(2):95-97.
[18]
Wang WM, Liu JY, Zhao SY, Liu YQ. Clinical Study of Repair of Interictcal SPECT Abnormal Perfusion Foci and V-EEG of Temporal Lobe Epilepsy with Patients in Long-term Control with Antiepilepsy Drugs. Zhongguo Linchuang Shengjing Kexue.2010;18(5):512-517.
[19]
Xu L, Wang WM. Protective effects of cocktail therapy on neurons in pentetrazol-induced seizures rat. Shangdong Yiyao. 2006;46 (11):19-20.
[20]
Wang WM, Song WJ, Dang XL, Fan ZY, Yang YX, Zhang YQ. Prognosis and SPECT abnormal of the first seizure patients:33 cases report. Zhonghua Yishi Zazhi. 2011;5(8):2459-2461.
[21]
Dang XL, Wang WM. The changes of interictcal SPECT and EEG before and afler treatment in 35 patients with aura continua. Dianxian yu Shenjing Dianshenglixue Zazhi. 2011;20(5):295-298.
[22]
Fan ZY, Wang WM. Related factors analysis of repair of abnormal perfusion foci on SPECT in epileptic patients after treatment. Dianxian yu Shenjing Dianshenglixue Zazhi. 2012; 21(5):272-276.
[23]
Zhang YQ, Wang WM. Contrast studies of fepairation of abnormal perfusion foci on SPECT in epileptic patients with the treated by carbamazepine and valproate with the application of traditional Chinese medicine. Dianxian yu Shenjing Dianshenglixue Zazhi. 2013;22(1):5-10.
[24]
Wang WM, Zhang YQ, Fan ZY, Yang YX, Dang XL, Song WJ, Liu YQ, Wu YP, Ye J. The forecast of related information of early GTCS developing into temporal lobe epilepsy The study of clinical and long-term monitoring EEG and interictal SPECT and imaging. Dianxian yu Shenjing Dianshenglixue Zazhi, 2012,21;6:347-551.
[25]
Wang WM. Clinical Research of Abnormal Perfusion Foci of Epilepsy Repaired with Integrated Chinese and Western Medicine. Shijie Zhongxiyi Jiehe Zazhi. 2015;10(1):50-55.
[26]
Wang WM, Fan ZY. “Cocktail” therapy can repair early hippocampai damage (functional changes) in epilepsy patients. The 11th Asian & Oceanian Epilepsy Congress, 2016: 199.
[27]
Hogan RE, Bucholz RD, Joshi S. Hippocampal deformation-based shape analysis in epilepsy and unilateral mesial temporal sclerosis. Epilepsia. 2003;44(6):800-806.
[28]
Tan QF, Lin ZG. Manual of epilepsy surgery. 1st edition. Beijing: People’s Publishing House, 2010: 60.
[29]
Yang X, Chi ZF. Common comorbidity of epilepsy:a review of new progress. Zhongguo Xiandai Shenjing Jibing Zazhi, 2012,12:5:507-515.
[30]
Cendes F, Andermann F, Dubeau F, Gloor P, Evans A, Jones-Gotman M, Olivier A, Andermann E, Robitaille Y, Lopes-Cendes I, et al. Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy: an MRI volumetric study. Neurology. 1993;43(6):1083-1087.
[31]
Harvey AS, Grattan-Smith JD, Desmond PM, Chow CW, Berkovic SF. Febrile seizures and hippocampal sclerosis: frequent and related findings in intractable temporal lobe epilepsy of childhood. Pediatr Neurol. 1995;12(3):201-206.
[32]
VanLandingham KE, Heinz ER, Cavazos JE, Lewis DV. Magnetic resonance imaging evidence of hippocampal injury after prolonged focal febrile convulsions. Ann Neurol. 1998;43(4):413-426.
[33]
Cavazos JE, Das I, Sutula TP. Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures [J]. J Neurosci,1994,14(5 Pt 2) :3106-3121.
[34]
Shang W, Pang Q, Liu WH, Li SM. Neuron apoptosis and Bcl-2, Bax, P53 protein expression in human temporal lobe epilepsy. Shandong Daxue XuebaoYixueban. 2005; 43(2): 134-137.
[35]
Huang MF, Zhang YL, Ren ZZ, Qiao YJ. Study on Mechanism of Chinese Herbal Medicine for Activating Blood Circulation to Remove Stasis in Treating Coronary Artery Disease Using Network Pharmacology Method. Shijie Kexue Jishu –Zhongyiyao Xiandaihua. 2012; 14:5: 1969-1975.
[36]
Zhu XQ. Study on the Effects of Tetramethylpyrazine in Treating Epilepsy and its Relation to Neurotransmitter. Shizhen Guoyiguoyao. 2007; 18(10): 2391-2392.
[37]
Zhu XQ, Lei SS. Effect of Tetramethylpyrazine on Epilepsy Model of Signaling Molecule in Hippocampus of Rats. Liaoning Zhongyi Zazhi. 2007; 34(11): 1530-1531.
[38]
Xue GF, Li GL, Zhao BZ, Li DF, Niu HY, Zheng JY, Wang GQ, Cheng WJ, Qi DB. Effects of edaravone on free radical metabolism and hippocampal neuron apoptosis in rats following status epilepticus. Zhongguo Yaowu yu Linchuan. 2011; 11(4): 385-387.
[39]
Zhou J, Lu YC, Sun KH, Yang Q. Effects of Citicoline, Meclofenoxate, GM1 Ganglioside on Some Intracerebral Endogenous Substances in Rats with Epilepsy Induced by Penicillin. Zhongguo Linchuang Shenjing Waike Zazhi. 2007; 12(11): 668-672.
[40]
Ram Z, Sadeh M, Shacked I, Sahar A, Hadani M. Magnesium sulfate reverses experimental delayed cerebral vasospasm after subarachnoid hemorrhage in rats. Stroke. 1991;22(7):922-927.
[41]
Li YM, Chen FP, Liu GQ. Studies on Inhibitive Effect of Gastrodin on PC12 Cell Damage Induced by Glutamate and H2O2. Zhongguo Yaoke Daxue Xuebao. 2003; 34(5): 456-460.
[42]
Zeng XH, Ge YK, Yan M, Zheng XX. Protective effect of gastrodin on hippocampal neurons injury induced by acidosis. Zhongcaoyao. 2007; 38(12): 1867-1869.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
CONTACT US
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
E-mail:
LET'S GET IN TOUCH
Name
E-mail
Subject
Message
SEND MASSAGE
Copyright © 2013-2017, Open Science Publishers - All Rights Reserved