Traditional Chinese Medicine Combined with Western Medicine for the Treatment of Early Hippocampal Sclerosis in Patients with Epilepsy
Objective: To block the disease progression from FS to HS to TLE, control GTCS immediately after or in the early stage of febrile seizure, and repair HS (functional change) in patients with early epilepsy onset are the key to repair of mild HS injury. We proposed traditional Chinese medicine combined with western medicine for the treatment (neuroprotectant combined with cocktail) of HS (functional change) in patients with early epilepsy onset as confirmed by abnormal MRS findings. Methods: Thirty patients with epilepsy who received treatment between 2012 and 2013, consisting of 16 males and 14 females, aged 5-34 years, were included in this study. All of them underwent pre-and post-treatment MRI, MRS and inter-ictal brain SPECT imaging, V-EEG monitoring. AEDs together with neuroprotectant combined with cocktail were used for 10 days. Serum AEDs level was monitored. The N-acetylaspartate (NAA)/ (creatine (Cr) and choline (Cho)) value was calculated. All patients were followed up for 2 weeks to 1 year. Results: As per the types of epileptic seizure, GTCS in 17 patients, TLE in 10 patients and other types of seizure in 3 patients. Epileptic seizure was controlled for an average of 37.6 months in 20 (66.7%) patients and it was not controlled in 10 patients (33.3%). Prior to treatment, MRI normalities were in 18 (60%) patients and abnormal MRI findings in 12 (40%) patients. MRS abnormalities were all 30 (100%) patients, with NAA/(Cr+Cho) value < 0.68 (average 0.60±0.03 (range 0.53-0.66), indicative of early HS in epilepsy onset. After treatment, MRS normalities were 16 (53.33%) patients, and NAA/(Cr+Cho) value (> 0.7) recovered to normal in these 16 patients, and there was significant difference between prior to and after treatments (P <0.05). After treatment, MRI normalities were 16 patients and abnormal MRI findings in 14 patients. There were two patients who showed MRI normalities prior to treatment but abnormal findings after treatment: reduced hippocampal volume, increased signal intensity, enlarged temporal horns, and further decreased NAA/(Cr+Cho) value. Conclusion: Sixteen out of 30 epilepsy patients presenting with HS (functional change) had normal MRS findings (53.33%) after treatment of neuroprotectant combined with cocktail. These results indicate that mild HS can be partially reversed, and the combined therapy provides a new therapy for blocking the progression of TLE from GTCS. and reduced drug-fast TLE and For a third group TLE accounted for epilepsy group (5000 ten thousand) of has strategic significance.
Epilepsy, Repair, Neuroprotectant Combined with Cocktail, Mild HS, Functional Change, NAA/(Cr+Cho) Value
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