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Correlation of Retinal Nerve Fibre Layer Thinning and Central Subfield Thickness with Type 2 Diabetic Retinopathy on Spectral Domain Optical Coherence Tomography
Current Issue
Volume 3, 2015
Issue 6 (December)
Pages: 194-198   |   Vol. 3, No. 6, December 2015   |   Follow on         
Paper in PDF Downloads: 61   Since Oct. 23, 2015 Views: 1815   Since Oct. 23, 2015
Khushboo Srivastav, Retina Service, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Sandeep Saxena, Retina Service, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Surabhi Ruia, Retina Service, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Abbas A. Mahdi, Department of Biochemistry, King George’s Medical University, Lucknow, India.
Vinay Khanna, Indian Institute of Toxicology and Research, Lucknow, India.
Purpose: To study the correlation of retinal nerve fibre layer (RNFL) thinning and central subfield thickness (CST) with severity of type 2 diabetic retinopathy (DR) on spectral domain optical coherence tomography (SD-OCT). Methods: Sixty consecutive cases of type 2 diabetes mellitus were divided into three groups: diabetes without retinopathy (NO DR; n=20), non-proliferative diabetic retinopathy (NPDR; n=20), and proliferative diabetic retinopathy (PDR; n=20). Twenty healthy controls were included. Visual acuity (VA) was assessed on logMAR scale. Glycosylated hemoglobin (HbA1c) was assessed using standard protocol. Average RNFL thickness and CST were measured using SD-OCT. Data was analyzed statistically. Results: Significant decrease in RNFL thickness was observed with increase in severity of DR (F=21.92, p<0.001). Significant increase in CST and logMAR VA with increase in severity of DR was also observed (F=33.18; F=47.19 respectively, p<0.001). On Pearson correlation, significant negative correlation of RNFL thickness with VA, CST and HbA1c (r= -0.62; r= -0.575; r= -0.357, p<0.001) was observed whereas significant positive correlation between logMAR VA and CST (r= 0.35; p<0.05) was also observed. Multiple regression analysis revealed CST to be the sole predictor of impaired visual acuity (OR=3.07, 95% CI=1.16–8.16, p<0.05). Conclusion: RNFL thinning is associated with progression of diabetic retinopathy, poor glycemic control and increase in CST. RNFL thinning does not contribute significantly to visual impairment in type 2 diabetic retinopathy.
Retinopathy, Diabetes Mellitus, Retinal Nerve Fibre Layer, Central Subfield Thickness, Spectral Domain Optical Coherence Tomography
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