Correlation of Retinal Nerve Fibre Layer Thinning and Central Subfield Thickness with Type 2 Diabetic Retinopathy on Spectral Domain Optical Coherence Tomography

Khushboo Srivastav; Sandeep Saxena; Surabhi Ruia; Abbas A. Mahdi; Vinay Khanna

doi:7170227

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Correlation of Retinal Nerve Fibre Layer Thinning and Central Subfield Thickness with Type 2 Diabetic Retinopathy on Spectral Domain Optical Coherence Tomography

Current Issue

Volume 3, 2015
Issue 6 (December)

Pages: 194-198 | Vol. 3, No. 6, December 2015 | Follow on

Paper in PDF Downloads: 61 Since Oct. 23, 2015 Views: 1935 Since Oct. 23, 2015

Authors

[1]

Khushboo Srivastav, Retina Service, Department of Ophthalmology, King George’s Medical University, Lucknow, India.

[2]

Sandeep Saxena, Retina Service, Department of Ophthalmology, King George’s Medical University, Lucknow, India.

[3]

Surabhi Ruia, Retina Service, Department of Ophthalmology, King George’s Medical University, Lucknow, India.

[4]

Abbas A. Mahdi, Department of Biochemistry, King George’s Medical University, Lucknow, India.

[5]

Vinay Khanna, Indian Institute of Toxicology and Research, Lucknow, India.

Abstract

Purpose: To study the correlation of retinal nerve fibre layer (RNFL) thinning and central subfield thickness (CST) with severity of type 2 diabetic retinopathy (DR) on spectral domain optical coherence tomography (SD-OCT). Methods: Sixty consecutive cases of type 2 diabetes mellitus were divided into three groups: diabetes without retinopathy (NO DR; n=20), non-proliferative diabetic retinopathy (NPDR; n=20), and proliferative diabetic retinopathy (PDR; n=20). Twenty healthy controls were included. Visual acuity (VA) was assessed on logMAR scale. Glycosylated hemoglobin (HbA1c) was assessed using standard protocol. Average RNFL thickness and CST were measured using SD-OCT. Data was analyzed statistically. Results: Significant decrease in RNFL thickness was observed with increase in severity of DR (F=21.92, p<0.001). Significant increase in CST and logMAR VA with increase in severity of DR was also observed (F=33.18; F=47.19 respectively, p<0.001). On Pearson correlation, significant negative correlation of RNFL thickness with VA, CST and HbA1c (r= -0.62; r= -0.575; r= -0.357, p<0.001) was observed whereas significant positive correlation between logMAR VA and CST (r= 0.35; p<0.05) was also observed. Multiple regression analysis revealed CST to be the sole predictor of impaired visual acuity (OR=3.07, 95% CI=1.16–8.16, p<0.05). Conclusion: RNFL thinning is associated with progression of diabetic retinopathy, poor glycemic control and increase in CST. RNFL thinning does not contribute significantly to visual impairment in type 2 diabetic retinopathy.

Keywords

Retinopathy, Diabetes Mellitus, Retinal Nerve Fibre Layer, Central Subfield Thickness, Spectral Domain Optical Coherence Tomography

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