Aim: To evaluate the efficacy of 3% Sodium Tetra Decyl Sulphate as a sclerosant in treatment of orbitopalpebral cysts associated with severe microphthalmos/ anophthalmos. Methods: Prospective, interventional study on eight patients diagnosed as congenital orbitopalpebral cysts with severe microphthalmos/ anophthalmos, aged 2-24 years. After aspiration of the orbitopalpebral cyst, 3% sodium tetradecyl sulphate in dose of 0.5ml per 10 ml of aspirated fluid was injected into the collapsed cyst. Conformer was placed and bandage applied for one day. Patients were kept under antibiotic cover for five days. Follow up was done at the end of one, three, six and nine months following last dose to evaluate the regression of orbitopalpebral cyst. Sclerosant therapy was repeated if recurrence of cyst was noted. Regression of orbitopalpebral cyst to cosmetically acceptable level was the target. Results: Post sclerotherapy, all orbitopalpebral cysts underwent regression within a period of nine months. Three orbitopalpebral cysts underwent complete regression following a single dose of sclerotherapy, four required a repeat dose and one of the patients required a third dose of sclerotherapy. Conclusion: All 8 patients of unilateral congenital orbitopalpebral cyst with anophthalmos / severe microphthalmos treated with 3% Sodium tetradecyl sulphate attained regression of cyst size in one to three sittings over a period of nine months, without any adverse effects. Number of sittings required was less in orbitopalpebral cysts with lesser aspirate.

SodiumTetradecyl Sulphate, STS, Sclerosing Agent, Orbitopalpebral Cyst, Anophthalmos, Microphthalmos