Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
A Study on Cyst Volume Dependent Dose of 3% Sodium Tetradecyl Sulphate in Sclerotherapy of Orbitopalpebral Cyst Associated with Severe Microphthalmos/Anophthalmos
Current Issue
Volume 3, 2015
Issue 5 (October)
Pages: 173-176   |   Vol. 3, No. 5, October 2015   |   Follow on         
Paper in PDF Downloads: 33   Since Sep. 19, 2015 Views: 1890   Since Sep. 19, 2015
Apjit Kaur Chhabra, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Sonal Bangwal, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Nibha Mishra, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Aim: To evaluate the efficacy of 3% Sodium Tetra Decyl Sulphate as a sclerosant in treatment of orbitopalpebral cysts associated with severe microphthalmos/ anophthalmos. Methods: Prospective, interventional study on eight patients diagnosed as congenital orbitopalpebral cysts with severe microphthalmos/ anophthalmos, aged 2-24 years. After aspiration of the orbitopalpebral cyst, 3% sodium tetradecyl sulphate in dose of 0.5ml per 10 ml of aspirated fluid was injected into the collapsed cyst. Conformer was placed and bandage applied for one day. Patients were kept under antibiotic cover for five days. Follow up was done at the end of one, three, six and nine months following last dose to evaluate the regression of orbitopalpebral cyst. Sclerosant therapy was repeated if recurrence of cyst was noted. Regression of orbitopalpebral cyst to cosmetically acceptable level was the target. Results: Post sclerotherapy, all orbitopalpebral cysts underwent regression within a period of nine months. Three orbitopalpebral cysts underwent complete regression following a single dose of sclerotherapy, four required a repeat dose and one of the patients required a third dose of sclerotherapy. Conclusion: All 8 patients of unilateral congenital orbitopalpebral cyst with anophthalmos / severe microphthalmos treated with 3% Sodium tetradecyl sulphate attained regression of cyst size in one to three sittings over a period of nine months, without any adverse effects. Number of sittings required was less in orbitopalpebral cysts with lesser aspirate.
SodiumTetradecyl Sulphate, STS, Sclerosing Agent, Orbitopalpebral Cyst, Anophthalmos, Microphthalmos
Duke-Elder S. Normal and abnormal development. Congenital deformities. In: System of ophthalmology. St Louis: CV Mosby, 1963; 3:483.
Chaudhry, Imtiaz A., Arat, Yonca O., Shamsi, Farrukh A. et al. Congenital Microphthalmos With Orbital Cysts: Distinct Diagnostic Features and Management. Ophthalmic Plastic & Reconstructive Surgery 2004 November; 20(6): 452-57.
Milind N. Naik, Ramesh K. Murthy, Kuldeep Raizada, Santosh G. Honavar. Ethanolamine Oleate Sclerotherapy in the Management of Orbito-palpebral Cyst Associated with Congenital Microphthalmos. American Journal of Ophthalmology 2005 May; 139(5): 939-41.
Naik MN, Batra J, Nair AG, Ali MJ, Kaliki S, Mishra DK. Foam sclerotherapy for periorbital dermoid cysts. Ophthal Plast Reconstr Surg.2014 May-Jun; 30(3):267-70.
Smriti Nagpal, Ruchi Goel, Sushil Kumar, Sonam Garg. Sclerosing Agents in Ophthalmology. Delhi journal of ophthalmology 2013; 23(3): 221-226.
Goldman MP. Sodium tetradecyl sulfate for sclerotherapy treatment of veins: is compounding pharmacy solution safe. Dermatol Surg 2004; 30: 1454-6.
Weiss RA, Dover JS. Leg vein management: Sclerotherapy, ambulatory phlebectomy, and laser surgery. Semin Cutan Med Surg 2002; 21(1):76-103.
Sadick N, Li C. Small-vessel sclerotherapy. Dermatol Clin 2001; 19(3): 475-81.
Kern P. Sclerotherapy of varicose leg veins. Technique, indications and complications. Into Angelo 2002; 21(2 Suppl 1):40-5.
Chiu K-W, Changchien C-S, Chuah S-K, et al. Endoscopic injection sclerotherapy with 1.5% Sotradecol for bleeding cardiac varices. J Clin Gastroenterol 1997; 24: 161-4.
Ravi M, Kate V, Ananthakrishnan N. Prospective randomized comparison of sodium tetradecyl sulphate & polidocanol for oesophageal variceal sclerotherapy. Indian J Med Res. 2001 Jun; 113: 228-33.
Demir E, Alan C, Kilciler M, Bedir S. Comparison of ethanol and sodium tetradecyl sulfate in the sclerotherapy of renal cyst. J Endourol. 2007 Aug; 21(8): 903-5.
Cho DS, Ahn HS, Kim SI, Kim YS, Kim SJ, Jeon GSet al. Sclerotherapy of renal cysts using acetic acid: a comparison with ethanol sclerotherapy. Br J Radiol. 2008 Dec; 81(972):946-9.
Long Li, Cai-Chan Chen, Xin-Qiao Zeng. One-year Results of Single-session Sclerotherapy with Bleomycin in Simple Renal Cysts. Journal of Vascular and Interventional Radiology 2012; 23(12): 1651-56.
Alon Kahana, MD, PhD; Brenda L. Bohnsack, MD, PhD; Raymond I. Cho, MD; Cormac O. Maher, MD. Subtotal Excision with Adjunctive Sclerosing Therapy for the Treatment of Severe Symptomatic Orbital Lymphangiomas. Arch Ophthalmol. 2011; 129(8):1073-10765.
Churchill P, Otal D, Pemberton J, Ali A, Flageole H, Walton JM. Sclerotherapy for lymphatic malformations in children: a scoping review.J Pediatr Surg. 2011 May; 46(5):912-22.17. Saha K, Leatherbarrow B. Orbital lymphangiomas: a review of management strategies. Curr Opin Ophthalmol. 2012 Sep; 23(5): 433-8.
SR Jayesh, Pankaj Mehta, Mathew P Cherian, V Ilayaraja, Prashanth Gupta, K Venkatesh. Efficacy and safety of USG-guided ethanol sclerotherapy in cystic thyroid nodules. Indian Journal of Radiology and Imaging 2009 July-September; 19(3): 199-202.
Jin Hong Yu, Yong Du, Yang Li, Han Feng Yang, Xiao Xue Xu et al. Effectiveness of ct-guided sclerotherapy with estimated ethanol concentration for treatment of symptomatic simple hepatic cysts. Clinics and Research in Hepatology and Gastroenterology2014 April; 38(2):190-194.
Sarin SK, Kumar A. Sclerosants for variceal sclerotherapy: a critical appraisal. Am J Gastroenterol 1990; 85: 641-9.
W. K. Blenkinsopp. Comparison of tetradecyl sulphate sodium with other sclerosants in rats. Br J Exp Pathol. Apr 1968; 49(2): 197–201.
Sodium Tetradecyl Sulfate (Sodium tetradecyl sulfate 0.2% solution for injection 5ml vials). http://www.nhs.uk/medicine-guides/pages/MedicineSideEffects.aspx?condition=Varicose%20veins&medicine=sodium%20tetradecyl%20sulfate&preparation=
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
Copyright © 2013-, Open Science Publishers - All Rights Reserved