Reduced Ubiquinone Plasma Levels and Oxidative Stress in Ankylosing Spondylitis and Rheumatoid Arthritis
65 RA-patients, 29 AS-patients and 21 healthy persons (controls) were investigated to obtain information about the serum concentration of the radical scavenger ubiquinone (coenzyme Q10) in patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS). Measured parameters: Ubiquinone, total antioxidant status (TAS), oxidized LDL antibodies (oxLDL-AB), copper zinc superoxide dismutase (Cu/ZnSOD), rheumatoid factor, anti-citrullinated protein antibodies (ACPA) and anti-RA33 antibodies. Ubiquinone was significantly decreased in patients with RA (p<0.03) and AS (p<0.01) compared to healthy controls; and oxLDL-AB were significantly increased (p<0.001 and p<0.05). No significant differences were found concerning TAS and Cu/ZnSOD. However, a positive correlation was seen between ubiquinone and TAS (p<0.01) in AS. We conclude that in chronic inflammatory diseases such as RA and AS, ubiquinone is decreased leading to oxidative imbalance with raised oxLDL which may further enhance inflammation, tissue damage, and cardiovascular risk.
Ubiquinone Coenzyme Q10, Rheumatoid Arthritis, Ankylosing Spondylitis, Oxidative Stress
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