Detection of Abnormalities for Diagnosing of Children with Asperger Disorder Using of Quantitative Electroencephalography Analysis
Asperger disorder, one of the autistic spectrum disorders, is characterized by impairments in reciprocal social interaction and communication. In this study, spectrogram and coherence values with statistical analysis are used for evaluating quantitative electroencephalography (qEEG).Seventeen children with Asperger disorder (aged between 6 to 11)and thirteen control children (same age) were examined. It is shown that gamma frequency band (34-44Hz) could be used to separate the two groups very well (96.7%) in relaxed eye-opened condition. The children with Asperger disorder showed significant lower spectrogram criteria value (p<0.01) at Fp1 electrode and (p<0.05) at Fp2 and T6. Coherence values at 112 pairs of EEG neighbor electrodes indicated that the connectivity at electrode pairs (T4, P4), (T4, Cz), (T4, C4) and (T4, O1) had significant differences (p<0.01). More abnormalities were related to the connectivity of right temporal lobe with the other lobes. The results demonstrate that analysis of qEEG is useful for diagnosis of children with Asperger disorder using spectrogram and coherence values.
Asperger and Autism Disorders, Quantitative Electroencephalography, Spectrogram and Coherence Values
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