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Altered Lipid Profile is Associated with External Limiting Membrane and Inner Segment Ellipsoid Band Disruption in Type 2 Diabetes Mellitus: A Preliminary Study
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Volume 3, 2015
Issue 2 (April)
Pages: 37-41   |   Vol. 3, No. 2, April 2015   |   Follow on         
Paper in PDF Downloads: 11   Since Aug. 28, 2015 Views: 1746   Since Aug. 28, 2015
Astha Jain, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Sandeep Saxena, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Surabhi Ruia, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Khushboo Srivastav, Department of Ophthalmology, King George’s Medical University, Lucknow, India.
Shankar M Natu, Department of Pathology, King George’s Medical University, Lucknow, India.
Aims: To establish a correlation between lipid profile and disruption of external limiting membrane (ELM) and inner segment ellipsoid band (ISel) in type 2 diabetes mellitus (DM), for the first time. Method: Study subjects included 60 cases of type 2 DM [no diabetic retinopathy (No DR) (n=20); non proliferative DR (NPDR, n=20); proliferative DR (PDR, n=20)] and 20 healthy controls. Best corrected visual acuity was measured on logMAR scale. Spectral domain optical coherence tomography (SD-OCT) was used to grade the disruption of ELM and ISel as: grade 0 - No disruption of ELM and ISel; grade 1 - ELM disrupted, ISel intact; grade 2 - ELM and ISel disrupted. Serum was analyzed for levels of cholesterol, triglycerides and lipoproteins. Data was analyzed statistically. Results: Macular edema was observed in 17 cases of NPDR and in all cases of PDR. The ELM and ISel disruption correlated significantly with increased levels of cholesterol (r=0.35), triglycerides (r=0.28) and low density lipoprotein (r=0.34). ELM and ISel disruption was associated with decrease in visual acuity. Conclusion: Deranged lipid profile correlates with the progression of diabetic retinopathy, disruption of ELM and ISel on SD-OCT and decrease in visual acuity.
Diabetic Retinopathy, Lipid Profile, Spectral Domain Optical Coherence Tomography, External Limiting Membrane, Inner Segment Ellipsoid Band
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