Renal Effects of Ibuprofen during the Treatment of Patent Ductus Arteriosus in Low Birth Weight Premature Infants
[1]
Edmond Pistulli, Pediatric Department, University Hospital Center Mother Theresa, Tirana, Albania.
[2]
Alketa Hoxha Qosja, Neonatology Department, University Hospital for Obstetrics and Gynecology, Tirana, Albania.
[3]
Diamant Shtiza, Pediatric Nephrology Department, University Hospital Center Mother Theresa, Tirana, Albania.
[4]
Maks Basho, Imagery Department, University Hospital Center Mother Theresa, Tirana, Albania.
[5]
Gentian Vyshka, Faculty of Medicine, University Hospital Center Mother Theresa, Tirana, Albania.
Background: Aim of this study was to assess the efficacy and safety of oral ibuprofen and intravenous ibuprofen for the early pharmacological treatment of patent ductus arteriosus (PDA) in preterm infants. Methods: A randomized, single-blinded, controlled study performed on premature neonates, from January 2010 to December 2012. The study enrolled 68 preterm infants with gestational age between 28-32 weeks, birth weight ≤ 2000 g, postnatal age 48-96 h, and had echocardiographically confirmed significant PDA. The preterm infants received either intravenous or oral ibuprofen randomly as an initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 h. Serum creatinine (sCr), blood urea nitrogen (BUN) and urine output (UO) were recorded prior to start treatment, and after the course treatment. Results: 36 patients were treated with oral ibuprofen and 32 with intravenous ibuprofen in this period. After the first course treatment, the PDA closed in 30 (83.3%) of the patients assigned to the oral ibuprofen group versus 23 (71.8%) of those enrolled in the intravenous ibuprofen group (p=0.355). In the evaluation of renal tolerance, none of the patients had oliguria. The serum creatinine levels after the first and after the second treatment course did not differ significantly from the baseline for each group. Conclusions: Oral ibuprofen treatment seems to be as efficient as intravenous ibuprofen in closing PDA on the third day of life in low birth weight preterm infants and without significant changes of renal function.
Ibuprofen, Patent Ductus Arteriosus, Renal Function, Serum Creatinine Level
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