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Comparative Haemorrheological Changes in Third Trimester of Pregnancy and in the First Stage of Labour
Current Issue
Volume 2, 2014
Issue 5 (October)
Pages: 98-102   |   Vol. 2, No. 5, October 2014   |   Follow on         
Paper in PDF Downloads: 17   Since Aug. 28, 2015 Views: 1718   Since Aug. 28, 2015
Authors
[1]
Ozor M. O., Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria.
[2]
Omorogiuwa A., Department of Physiology, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Edo State, Nigeria.
Abstract
Physiological modification of blood during pregnancy has been well documented. In the same vein, stressors have been implicated in blood profile changes. This study therefore investigates the haemorrheological changes in normal pregnancy and during the first stage of labour; since labour is a highly stressful physiological event. This study was conducted in Benin City, Nigeria and it involves 10 normal pregnant women in their 3rd trimester (control) and 10 parturient in their first stage of labour (test). Blood sample was collected from each subject and analysed using Swelab Alfa Automated Haematology Analyzer. The results showed that except for MCHC, pregnant women in their third trimester of pregnancy (as control) have a non significant higher RBC, MCV, RDWa, RDW, Hct, HGB and MCH than parturients women in their first stage of labour. On the other hand, parturients women in their first stage of labour have significantly higher (p<0.05) mean relative plasma viscosity and fibrinogen concentration than pregnant women in their third trimester of pregnancy (as control). Based on the findings of this study, stress induced by first stage of labour may has significant effect on relative plasma viscosity and fibrinogen concentration. By implication, parturient should be optimized in terms of hydration and normoglycemia during the first stage of labour.
Keywords
Labour, Pregnancy, Haemorrheology, Benin City, Nigeria
Reference
[1]
T.F. Ashavaid, S.P. Todur, A.J. Dherai. ‘Establishment of reference intervals in Indian population.’ Ind. J. Clin. Biochem., 20(2):110–8. 2005.
[2]
MS El-Sayed. Effects of exercise and training on blood rheology. Sports Med, 26: 281-92. 1998.
[3]
JF Brun, S Khaled, E Raynaud, D Bouix, JP Micallef, A Orsetti. Triphasic effects of exercise on blood rheology: which relevance to physiology and pathophysiology? Clinical Hemorheology Clin Hemorheol Microcirc, 19: 89-104. 1998.
[4]
E Ernst, L Daburger and T Saradeth. The kinetics of blood rheology during and after prolonged standardized exercise. Clin Hemorheol, 11: 429-439. 1991.
[5]
E Ernst. Influence of regular physical activity on blood rheology. Eur Heart J., 8: suppl G, 59- 62. 1987.
[6]
E Ernst, A Matrai. Regular physical exercise increases blood fluidity. Rev Port Hemorreol, 1, 33-40. 1987.
[7]
SE Charm, H Paz and GS Kurland. Reduced plasma viscosity among joggers compared with non joggers. Biorheology, 15, 185-191. 1979,
[8]
JF Brun, C Fons, I Supparo, C Mallard, A Orsetti. Could exercise-induced increase in blood viscosity at high shear rate be entirely explained by hematocrit and plasma viscosity changes? Clin Hemorheol, 13: 187-199. 1993.
[9]
C Lacombe, C Bucherer, JC Lelievre, E Perreaut, P Curty, H Vandewalle. Effects hemorheologiques consecutifs a des exercices physiques ontroles sur ergocyle. (Hemorheologic effects following ergometric-controlled physical exercise) J Mal Vasc; 16: 79-82. 1991.
[10]
G Ciuffetti, M Mercuri, R Lombardini, U Milia, E Mannarino. Physical exercise and blood flow properties. Br J Sports Med, 24, 45-6. 1990
[11]
M.W. Fleming. Cortisol as an indicator of severity of parasitic infections of Haemoncus contortus in lambs (Ovis aries). Comparative Biochemistry and Physiology B, 116, 41-44. 1997.
[12]
D.K. Revell, S.F. Main, B.H. Breier, Y.H. Cottam, M. Hennies, S.N. Mccutcheon. Metabolic responses to mid-pregnancy shearing that are associated with a selective increase in the birth weight of twin lambs. Domestic Animal Endocrinology 18, 409-412. 2000.
[13]
A.R. Gennazzani, F. Fraioli, J. Hurlmann, P. Fioretti, J.P. Felber. Immunoreactive ACTH and cortisol plasma during pregnancy: detection and partial purification of corticotrophin-like placental hormone: human chorionic corticotrophin. Clin. Endocrino; 4: 1-14. 1974.
[14]
F. Facchinetti, G. Centini, D. Parrini, F. Petraglia, N. D’antona, E.V. Cosmi, A.R. Gennazzani. Opioid plasma level during labour. Gynecol. Obstet Invest, 13: 155-163. 1982.
[15]
A. Huisman, J.G. Aarhoudse, M. Krans, H.J. Huisjes, V. Fidley, W.G. Zijlstra. Red cell aggregation during normal pregnancy. Br. J. Haematol, 68: 121-124. 1988.
[16]
P. Ozanne, O. Linderkamp, F.C. Miller, H.J. Meiselman. Erythrocyte aggregation during normal pregnancy. Am. J. Obstet. Gynecol., 147: 576-583. 1983.
[17]
P. Gaehtgens, S. Schickendantz. Rheological properties of maternal and neonatal blood. Bibl Anat, 13: 107-108. 1975.
[18]
M.E. Foley, R. Collins, D. McDonald. Whole blood viscosity in umbilical cord blood, adult pregnant and non-pregnant blood: the influence of plasma factors. Clin. Hemorheol; 3: 285. 1983
[19]
P.C. Buchan. Evaluation and modification of whole blood filtration in the measurement of erythrocyte deformability in pregnancy and the newborn. J. Hematol; 45: 97-105. 1980.
[20]
H.L. Reid, A.C. Ugwu. A simple technique for rapid Determination of plasma viscosity. Nigerian Journal of Physiological Sciences, 3:45-48. 1987.
[21]
G.K. Ingram, A suggested schedule for the rapid investigation of acute hemostatic failure. Journal of Clinical Pathology, 41:521-534. 1961.
[22]
R.L. Letcher, T.G. Pickering, S. Chien and J.H. Laragh, Effects of exercise on plasma viscosity in athletes and sedentary normal subjects, Clin. Cardiol. 4, 172–179. 1981.
[23]
J. Junker, H. Heinrich, H. Ulbrich, R. Schulte, E. Schönfeld, G. Köhler. Relationship between plasma viscosity and the first stage of labour. Vasc. Biol. 18, 870–875. 1998.
[24]
J.F. Brun, Hormones, metabolism and body composition as major determinants of blood rheology: Potential pathophysiological meaning, Clin. Hemorheol. Microcirc. 26, 63–79. 2002.
[25]
A.M. Ehrly, H. Landgraf, J. Hessler and K. Saeger-Lorenz, Influence of a videofilm-induced emotional stress on the flow properties of blood, Biorheology, 23(3), 268. 1986.
[26]
H.Q. Danish, P.S. Mohammad, K. Tahseen, T.A. Syed. Influence of maternal factors on hematological parameters of healthy newborns of Karachi. Pak J Physiol; 2009;5(2): 34-37. 2009.
[27]
R. Hasan, S. Inoue, A. Baneriee. Higher White blood cells counts and band forms in newborns delivered vaginally compared with those delivered by caesarean section. Ameri J Clin Path, 100(2):116–8. 1993.
[28]
K. Mears, F. McAuliffe, H. Grimes, et al: Fetal cortisol in relation to labour, intrapartum events and mode of delivery. J Obstet Gynecol, 24(2): 129 – 32. 2004.
[29]
G. Chirico, A. Gasparoni, Ciadelli, et al: Leukocyte counts in relation to the method of delivery during the first five days of life. Fetal and neonatal research; 75: 298 – 299. 1999.
[30]
V. Bricout, M. Guinot, M. Duclos et al., Apports des examens biologiques dans le diagnostic du surentrainement, Sci. Sports 21, 319–350. 2006.
[31]
S. Rodźko, J. Przepieść, J. Urban, et al: Influence of perinatal factors on haematological variables in umbilical cord blood. J Perinat Med, 33: 42 – 45. 2005.
[32]
M. Jaattela, P. Kuusela, E. Saksela. Demonstration of tumor necrosis factor-α in human amniotic fluids and supernatants of placental and decidual tissues. Lab Invest, 58: 48-52, 1988.
[33]
L.C. Miller, S. Isa, G. LoPreste, J.G. Schaller. C.A. Dinarello. Neonatal interleukin-1β, interleukin-6, and tumor necrosis factor-α. Cord blood levels and cellular production. J Pediatr 117: 961-965, 1990.
[34]
M. Hayashi, K. Zhu, T. Sagesaka, I. Fukasawa, N. Inaba. Amniotic fluid levels of tumor necrosis factor-alpha and soluble tumor necrosis factor receptor 1 before and after the onset of labor in normal pregnancies. Horm Metab Res 40(4): 251-256, 2008.
[35]
S. Marshall-Clarke, D. Reen, L. Tasker, J. Hassan.: Neonatal immunity. How well has it grown up? Immunol Today 21(1): 35- 41, 2000.
[36]
R. Romero, D.T. Brody, E. Oyarzun, M. Mazor, Y.K. Wu, J.C. Hobbins, S.K. Durum. Infection and labor. III. Interleukin-1: a signal for the onset of parturition. Am J Obstet Gynecol 160(5 Pt1): 1117-1123, 1989.
[37]
T.R. Mosmann, R.L. Coffman. Th1 and Th2 cells. Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7: 145-173, 1989.
[38]
E. Protonotariou, C. Chrelias, D. Kassanos, H. Kapsambeli, E. Trakakis, A. Sarandakou. Immune Response Parameters During Labor and Early Neonatal Life. In vivo; 24: 117-124. 2010.
[39]
Harkness J, Whittington RB. The viscosity of human plasma and its changes in disease and on the exhibition of drugs. Rhel Acta 1971;10(1):1435–528.
[40]
Tommaso MD, Ferretti C, Conforti D, D'Ancona RL, Baronci D, Cianciulli D, et al. [Hematocrit and hemoglobin, parameters of hematic viscosity, in pregnancy-induced hypertension]. Minerva Ginecol 1991;43(5):237-40. [Article in Italian]
[41]
Kametas N, Krampl E, McAuliffe F, Rampling MW, Nicolaides KH. Haemorheological adaptation during pregnancy in Latin American population. Eur J Haematol 2001;66(5):305–11.
[42]
Imoru M, Emeribe AO. Haemorrheological profiles in apparently healthy pregnant women in Calabar, Nigeria. African J Bio 2008;7(24):4354–8.
[43]
J.F. Brun, E. Varlet-Marie, P. Connes and I. Aloulou, Hemorheological alterations related to training and overtraining. Biorheology 47: 95–115. 2010
[44]
H. Vandewalle, C. Lacombe, J.C. Lelièvre and C. Poirot, Blood viscosity after a 1-h submaximal exercise with and without drinking, Int. J. Sports Med. 9 (1988), 104–107.
[45]
J.F. Brun, Exercise hemorheology as a three acts play with metabolic actors: is it of clinical relevance?, Clin. Hemorheol. Microcirc. 26 (2002), 155–174.
[46]
M.E. Foley, D.M. Isherwood, G.P. McNicol. Viscosity, haematocrit, fibrinogen and plasma proteins in maternal and cord blood. Br. J. Obstet. Gynaecol., 85: 500-504. 1978.
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