Minerals’ Composition of Different Types of Gallstones in Sudanese Population
[1]
Saadeldin Ahmed Idris, Associate professor of Surgery, Alzaeim Alazhari University, Faculty of Medicine, Khartoum, Sudan.
[2]
Kamal Elzaki Elsiddig, Associate professor of Surgery, University of Khartoum., Faculty of Medicine, Khartoum, Sudan.
[3]
Mohamed Mahmoud Hafiz, Associate professor of Surgery, Alzaeim Alazhari University, Faculty of Medicine, Khartoum, Sudan.
[4]
Aamir Abdullahi Hamza, Associate professor of Surgery, Bahri University, Faculty of Medicine, Khartoum, Sudan.
[5]
Mohammed H. F. Shalayel, Professor of Biochemistry, National College for Medical and Technical Studies, Khartoum, Sudan.
Background: Gallstone disease is one of the major surgical problems in Sudanese population. Aim: The study was conducted to determine the varying composition of cations and anions of gallstones in a Sudanese population. Materials and methods: A cross-sectional study included all patients with symptomatic calcular cholecystitis that confirmed ultrasonographically and treated by cholecystectomy after acceptance of the informed consent. It was conducted in Khartoum teaching hospital in the period between January 2010 and December 2011. The stones were powdered and dissolved in different appropriate solvents depending upon the type of chemical constituent to be analyzed. Collected data was analyzed statistically using SPSS version 21. Results: The study included 94 patients (six (6.4%) males and 88 (93.6%) females) with female to male ratio of 14.7:1. Their age ranged between 27 and 80 years, with mean age 0f 45.9 years (SD ± 10.3). The stones were multiple in 61 (64.9%), with predominance of pigment calculi as found in 48 (51.07%). The sodium, potassium, calcium, magnesium, copper, iron, inorganic phosphate, oxalate and chloride were found in all gallstones in different concentrations in each different type of stones, collectively these minerals constituted about 9.36% of the stones’ composition. Conclusion: Calcium, sodium, potassium, magnesium, and chloride had the highest concentrations in pigment stones. Inorganic phosphate, copper, and oxalate recorded the highest levels in cholesterol calculi whereas; iron content was the highest in mixed stones.
Gallstones (GS), Cholesterol Stone (CS), Pigment Stone (PS), Mixed Stone (MS), Cations, Anions
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