Role of Propolis in Improving Hepatic and Renal Damage in Boldenone Undecylenate in Male Rats
Although anabolic androgenic steroids like boldenone may increase lean muscle mass, strength, and the ability to train longer and harder, the serious side effects of steroid are many and may not be reversible. So, the present study was designed to investigate the role of propolis in improving hepatic and renal damage in boldenone in male rats. 40 adult rats were equally divided into four groups. 1st Control group includes animals that injected intramuscularly with olive oil for 12 weeks. 2nd group were rats receive propolis (intragastrically, 400 mg/kg body weight). 3rd experimental group include animals that receive intramuscular injections of boldenone (5 mg/Kg body weight) for 12 weeks. 4th group were co-treated group where rats receive boldenone (intramuscular injections, 5 mg/Kg body weight) and Proplis (intragastrically, 400 mg/kg body weight). Intramuscular injection of rats with boldenone showed a significant increased in GOT, GPT, urea, creatinine, cholesterol, triglycerides, HDL, albumin, total protein, sodium (Na), calcium (Ca), magnesium (Mg), malondialdehyde (MDA), nitric oxide (NO), total protein, total thiol, catalase activity and superoxide dismutase activity (SOD) in liver and kidney tissues when compared with the control group. On the other hand a significant decrease in LDL, alkaline phosphatase (ALP), potassium (K), total lipid and glutathione (GSH) in boldenone group when compared with the control group. These findings suggested that misuse of boldenone may contribute to a continuously damage of the hepatic and renal diseases so young people especially should be careful if they want to use such steroids to enhance their strength and endurance. This shows that the desired dose of boldenone can safely be used with propolis in improving hepatic and renal damage in boldenone in male rats.
Boldenone, Propolis, Oxidative Stress, Antioxidants, Liver, Kidney
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