Welcome to Open Science
Contact Us
Home Books Journals Submission Open Science Join Us News
Beneficial Role of Panax ginseng Root Aqueous Extract against Cisplatin Induced Blood Toxicity in Rats
Current Issue
Volume 3, 2015
Issue 1 (February)
Pages: 1-7   |   Vol. 3, No. 1, February 2015   |   Follow on         
Paper in PDF Downloads: 58   Since Aug. 28, 2015 Views: 2099   Since Aug. 28, 2015
Authors
[1]
Mohamed Basuony, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
[2]
Ezar Hafez, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
[3]
Ehab Tousson, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
[4]
Ahmed Massoud, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
[5]
Samar Elsomkhraty, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
[6]
Shimaa Eldakamawy, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
Abstract
Cisplatin is a water-soluble planar member of the platinum coordination complex class of anticancer drugs. The Current work aimed to study the effects of Ginseng extract against blood toxicity induced by Cisplatin in rats. A total 60 male albino rats were equally divided into six groups; the first and second groups were the control and ginseng groups respectively while the 3rd group was Cisplatin rat group; the 4th and 5th groups were Co- and post treated Cisplatin rat with ginseng respectively and the 6th group was Cisplatin self treated rat group. A significant increase in serum cholesterol, triglycerides, LDL, GPT, GOT, urea, creatinine, uric acids and MDA levels in Cisplatin group when compared with control group, in contrast, a significant decrease in HDl, calcium, potassium, albumin, GSH, catalase and total protein levels in Cisplatin group when compared with control group. Treatment of Cisplatin with ginseng improved the blood toxicity induced by Cisplatin. We can conclude that Co-treatment with ginseng has beneficial properties and can reduce the blood toxicity induced by Cisplatin.
Keywords
Cisplatin, Ginseng, Blood, Oxidative Stress, Antioxidants
Reference
[1]
[1] Ali, B.H., Al Moundhri, M.S., (2006): Agents ameliorating or augmenting the nephrotoxicity of Cisplatin and other platinum compounds. A review of some recent research. Food Chem Toxicol., 44: 1173-83.
[2]
Al-Malki, A.L., Sayed, A. A. R., (2014): Thymoquiine attenuates Cisplatin-induced hepatotoxicity via nuclear factor kappa- β. BMC Complementary and Alternative Medicine, 14:282.
[3]
Diab, A.A., Zahra, M.H., Hendawy, A.A., Hamza, R.Z., Mekky, G. A., (2014): Hepatoprotective Effect of Curcumin and Vitamin C against Cisplatin Induced Oxidative Stress and Toxicity in Albino Rats. Journal of American Science, 10 (11).
[4]
Tousson, E., Hafez, E., Masoud, A., Hassan A.A., (2014a): Abrogation by Curcumin on Testicular Toxicity Induced by Cisplatin in Rats. Journal of Cancer Research and Treatment, 2(3): 64-68.
[5]
Zheng X.N., Xiao-Wen, W., Li-Ya, L., Zi-Wei, X., Hsin-Yi, H., Jin-Sheng, Z., Duo, Z., Xu, Y., Jun, S., Jin-Tian, (2014)T. Puerh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats. DOI:http://dx.doi.org/10.7314/APJCP.,15.17.7389.
[6]
Lirdi, L.C., Stupp, T., Sasso-Cerri, E., Miraglia, S.M., (2008): Amifostine protective effect on Cisplatin-treated rat testis, The Anatomical Record, 291, 797-808.
[7]
Lebwohl, D., Canetta, R. (1998): Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer, 34: 1522–1534.
[8]
Nagwani, S., Tripathi, Y. (2010): Amelioration of Cisplatin induced nephrotoxicity by PTY: A herbal preparation. Food and Chemical Toxicology, 48: 2253-2258.
[9]
Naqshbandi, A., Khan, W., Rizwan, S., Khan, F. (2012): Studies on the protective effect of flaxseed oil on Cisplatin-induced hepatotoxicity. Hum Exp Toxicol., 31(4): 364-75.
[10]
Naqshbandi, A., Rizwan, S., Khan, S. (2013): Dietary supplementation of flaxseed oil ameliorates the effect of Cisplatin on rat kidney. J Functional Foods, 5: 316-326.
[11]
Nader, M.E., The´oreˆt, Y., Saliba, I., (2010): The role of intratympanic lactate injection in the prevention of Cisplatin-induced toxicity. Laryngoscope,120: 1208–1213.
[12]
Sastry, J., Kellie, S.J., (2005): Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose Cisplatin and amifostine. Pediatr Hematol Oncol., 22: 441– 445.
[13]
Kart, A., Cigremis, Y., Karaman, M., Hasan, O., (2010): Caffeic acid phenethyl ester (CAPE) ameliorates Cisplatin-induced hepatotoxicity in rabbit. Experimental and Toxicologic Pathology, 62: 45-52.
[14]
Florea, A.M., Büsselberg, D., (2011): Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects. Cancers, 3: 1351-1371.
[15]
Johnkennedy, N., Adamma, E., (2011): The protective role of Gongronema latifolium in acetaminophen induced hepatic toxicity in Wistar rats. Asian Pacific journal of tropical biomedicine, 151-154.
[16]
Tousson, E., Hafez, E., Zaki S, Gad, A., (2014b): P53, Bcl-2 and CD68 expression in response to amethopterin-induced lung injury and ameliorating role of l-carnitine. Biomedicine & Pharmacotherapy, 8(5): 631–639
[17]
Tousson, E., Hegazy, M., Hafez, E., Ahmed, E.A., (2014c): The Effect of L-carnitine on Amethopterin-induced Toxicity in Rat Large Intestine. Journal of Cancer Research and Treatment, 2(3): 55-63.
[18]
Tousson, E., Tawfeek, Z., Abu-Shaeir, W.A., Hassan, H., (2014d): Methotrexate-induced Hepatic and Renal Toxicity: Role of L-carnitine in Treatment. Biomedicine and Biotechnology, 2 (4): 85-92.
[19]
Alipour, F., Wankhade V., (2012): Protective activity of Ficus bengalensis leaf extract against, Cisplatin induced toxicity in mice. Asian Pacific J. Tropical Biomedicine, 1-5.
[20]
Yao, X., Panichpisal, K., Kurtzman, N., Nugent, K., (2007): Cisplatin nephrotoxicity: a review, Am J Med Sci., 334: 115-124.
[21]
Hofseth, L.J., Wargovich, M.J., (2007): Inflammation, cancer, and targets of Ginseng. J Nutr., 137: 183S-185S.
[22]
Kim, M.K., Lee, J.W., Lee, K.Y. Yang, D., (2005): Microbial conversion of major ginsenoside Rb1 to pharmaceutically active minor ginsenoside Rd. J. Microbiol., 43 (5): 456-462.
[23]
Kitts, D.D., Wijewickreme, A.N., and Hu, C., (2000): Antioxidant properties of a North American Ginseng extract. Mol Cell Biochem.; 203: 1-10.
[24]
Zhang, G.Z., Liu, A.L., Zhou, Y.B., San, X., Jin, T.W., Jin, y., (2008): Panax Ginseng ginsenoside-Rg (2) protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol, 115: 441-448.
[25]
Tietz, N.W., (1990): Clinical Guide to Laboratory tests. 2nd Ed. philadelphia: WB saunders, 566 46.
[26]
Grant, G.H, Silverman, L.M., Christenson, R.H., (1987): Amino Acids and Proteins. In: Tietz NW, Ed. Fundamentals of Clinical Chemistry. 3rd Ed. Philadelphia: WB saunders.
[27]
Schumann, G., Klauke, R., (2013): New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects. Clin Chim Acta., 327: 69-79.
[28]
Moss and Henderson, D.W., Moss, A.R., (1999): Henderson Clinical Enzymology C.A. Burtis, E.R. Ashwood (Eds.). Tietz Textbook of Clinical Chemistry (Third Ed.), W.B Saunders Company, Philadelphia, pp: 617- 721.
[29]
Henry, R.J., Sobel, C., Kim, J., (1957): A modified carbonate phosphotungstate method for the determination of uric acid, and comparison with the spectrophotometric uricase method. Am J Clin Pathol., 28: 152–160.
[30]
ossati, P., Principe, L., (1982): Enzymatic colorimetric method to determination triglycerides. Clin Chem., 28: 2077.
[31]
Ohkawa, W., Ohishi, N., Yagi, K., (1979): Assay for lipid peroxides in animal tissues by thiobarbituric aid reaction. Anal Biochem, 95: 351-358.
[32]
Tietez, F., (1969): Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem, 27:502.
[33]
Goth, L., (1991): A simple method for determination of serum catalase activity and revision of reference range. Clinics Chimica, 196: 143-152.
[34]
Thomas, L., (1998): Clinical Laboratory Diagnostics 1st Ed Frankfurt TH- Books Verlagsgesellschaft, 231-241.
[35]
Steadman, L.T., (1940): A. spectrochemical determination of sodium blood serum.The Journal of Biological Chemistry, 138:60.
[36]
Seong, H.K., Kyoung, O.H., Jae, K.H., Kwang-Kyun, P., (2005): Xanthorrhizol has a potential to attenuate the high dose Cisplatin-induced nephrotoxicity in. Food and Chemical Toxicology, 43: 117-122.
[37]
Abouzeinab, N.S., (2013): Cytoprotective ffect and antioxidant properties of silymarin on Cisplatin induced hepatotoxicity in Rats. A Biochemical and histochemical study. International Journal of Cancer Research, 9(1):9-23.
[38]
Sakeran, M.I., Zidan N., Rehman, H., Aziz, A.T., Saggu S., (2014): Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats. Redox Rep., 19(1): 26-33.
[39]
Saggu, S., Kumar, R., (2007): Modulatory effect of seabuckthorn leaf extract on oxidative stress parameters in rats during exposure to cold, hypoxia and restraint (C-H-R) stress and post stress recovery. J Pharm Pharmacol, 59 (12): 1739-1745.
[40]
Jadon, A., Bhadauria, M., Shukla, S., (2007): Protective effect of Terminalia belerica Roxb. and gallic acid against carbon tetrachloride induced damage in albino rats. J Ethnopharmacol., 109: 214-218.
[41]
Tousson, E., Atteya, E., El-Atrash, E., Jeweely, O.I., (2014e): Abrogation by Ginkgo Byloba Leaf Extract on Hepatic and Renal Toxicity Induced by Methotrexate in Rats. Journal of Cancer Research and Treatment, 2(3): 44-51.
[42]
Mansour, M.A., Mostafa, A.M., Nagi, M.N., Khattab, M.M., Al-Shabanah, O.A., (2002): Protective effect of aminoguanidine against nephrotoxicity induced by Cisplatin in normal rats. Comparative Biochemistry and Physiology Part C., 132: 123–128.
[43]
Prabhu, v.v., Kannan, N., Guruvayoorappan, G., (2013): 1, 2-Diazole prevents Cisplatin-induced nephrotoxicity in experimental. Pharmacological Reports, 65: 980-990.
[44]
Saleh, R.M., Awadin, W.F., Elseady, Y.Y., Waheish, F.E., (2014): Renal and Cardiovascular Damage Induced by Cisplatin in Rats. Life Science Journal, 11(2).
[45]
Naqshbandi, A., Khan, M.W., Rizwan, S., Yusufi, A.N.K., Khan, f. (2011): Studies on the protective effect of fish oil against Cisplatin induced hepatotoxicity. Biology and Medicine, 3 (2): 86-97.
[46]
Patel, B.M., Damle, D., (2013): Combination of Telmisartan with Cisplatin Controls Oral Cancer Cachexia in Rats. Hindawi Publishing Corporation Bio Med Research International, 642848, 10 pages.
[47]
Sekijima, T., Tanabe, A., Maruoka, R., Fujishiro, N., Yu, S., Fujiwara, S., (2011): Impact of platinumbased chemotherapy on the progression of atherosclerosis. Climacteric, 14: 31-40.
[48]
Santos, N.A., Carvalho Rodrigues, M.A., Martins, N.M., dos Santos, A.C., (2012): Cisplatin- induced nephrotoxicity and targets of nephroprotection an update. Arch toxicol., 86: 1233-1250.
[49]
Nuver, J., De Haas, E.C., Van Zweeden, M., Gietema, J.A., Meijer, C., (2010): Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and Cisplatin in vitro. Oncol reports, 23: 247-253.
[50]
Casares, C., Ramirez-Camacho, R., Trinidad, A., Roldan, A., Jorge, E., Garcia-Berrocal, J.R., (2012): Reactive oxygen species in apoptosis induced by Cisplatin: review of physiopathological mechanisms in animal models. European archives of oto-rhino-laryngology: official journal of the European Federation of Oto- Rhino-Laryngological Societies, 269, 2455-2459.
[51]
van Angelen, A.A., Glaudemans, B., van der Kemp, A.W.C.M., Hoenderop, JGJ., Bindels, R.J.M., (2012):Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice. Nephrol Dial Transplant, 1–9.
Open Science Scholarly Journals
Open Science is a peer-reviewed platform, the journals of which cover a wide range of academic disciplines and serve the world's research and scholarly communities. Upon acceptance, Open Science Journals will be immediately and permanently free for everyone to read and download.
CONTACT US
Office Address:
228 Park Ave., S#45956, New York, NY 10003
Phone: +(001)(347)535 0661
E-mail:
LET'S GET IN TOUCH
Name
E-mail
Subject
Message
SEND MASSAGE
Copyright © 2013-, Open Science Publishers - All Rights Reserved