Isolation and Characterization of 16-β-(β-D-Glucopyranosyl) Lanost -1, 5, 11, 15 –Tetraene-3–yl-6-0–(3/,4/,5/–Trimethoxycyclohexanoyl) -β-D–Glucopyranoside from the Leaves of Baphia nitida
[1]
JohnBull Onyekachi Echeme, Department of Chemistry, Michael Okpara University of Agriculture Umudike, Umuahia, Abia State, Nigeria.
[2]
Bright Chinenyeze Onyekwere, Department of Chemistry, Federal Polytechnic Nekede, Owerri, Imo State, Nigeria.
[3]
Rosemary Izunwanne Uchegbu, Department of Chemistry, Alvan Ikoku Federal College of Education, Owerri, Imo State, Nigeria.
Baphia nitida is one of the medicinal plants used widely in Nigeria by the herbalists for the treatment of different ailments such as ringworm, stiff joints, sprains, rheumatic pains and infectious diseases. Despite its rich pharmacological potential, the plant has not been scientifically evaluated. Thus the Chemical investigation of the bioactive constituents of the leaves of Baphia nitida resulted in the isolation of a new compound, 16-β-(β-D-glucopyranosyl) lanost -1, 5, 11, 15 –tetraene-3–yl-6-0–(3/,4/,5/–trimethoxycyclohexanoyl) -β-D–glucopyranoside. The structure was elucidated using a two dimensional spectroscopy, NMR (1H, 13C) spectroscopy in combination with IR and MS spectra data.
[1]
Adewuyi, A., Oderinde, R.A and Ajayi, I.A (2009).The Metal Composition, Proximate Properties and the Effect of Refining on the Physico-Chemical Characterization of Baphia nitida and Gliricidia sepium Seed and Seed Oil. Journal of Food Technology (7):2 Pg 43 – 49.
[2]
Agwa O.K, Uzoigwe, C.I. and Mbaegbu, A.O. Antimicrobial activity of camwood (Baphia nitida) dyes on common human pathogens. African Journal of Biotechnology
[3]
McMurry, J. (1998) Organic Chemistry. Books/Cole Publishing Company California. Pp. 1025 – 1031.
[4]
Njoku, V.O., Oguzie .E.E., Obi, C and A. A. Ayuk (2014). Baphia nitida Leaves Extract as a Green Corrosion Inhibitor for the Corrosion of Mild Steel in Acidic Media. Advances in Chemistry. 10 pages.
[5]
Numida, M.L (2009). “The effects of Raw and Processed Mucuna pruriens seed Based Diets on the growth parameters and meat characteristics of Benin Local Guinea Fowl”. International J. of Poultry sciences 8(9).
[6]
Okwu D.E and Ohenhen, O.N (2010). Isolation and characterization of Steroidal Glycosides from theleaves of Stachytarpheta Jamaicensis Linn Vahl. Der Chemica Sinica, 2010, 1 (2): 6-14
[7]
Onwukaeme, N.D (1995), “Anti-inflammatory activities of flavonoids of Baphia nitida Lodd. (Leguminosae) on mice and rats,” Journal of Ethnopharmacology, vol. 46, no. 2, pp. 121–124.
[8]
Uchegbu and Echeme (2013). Isolation and characterization of Estra – 2// -en – 17 – ol, 3 yl benzoate from Mucuna pruriens (Utilis). 2013. Journal of Natural Sciences Research,Vol 3 (11):84 – 87.
[9]
Walf, A.A and Frye, C.A. (2005). Anxiety and anti- depressive behavior produced by Physiological estradiol regimen may be modulated by hypothalamic – pituitary adrenal axis activity. Neuropsychopharmmacology 30(7): 1288 – 1301.
