In Vitro Antitumor and Antioxidant Activity of Meridianin Derivatives Synthesized from Indolylenaminonitriles under Microwave Irradiation
[1]
Asma Ahmed. Alarifi , Chemistry Department, Faculty of Applied Science, Umm Alqura Unicersity, Makkah, KSA.
[2]
Hanadi Yousef. Medrasi , Department of Chemistry, Sciences Faculty for Girls, King Abdulaziz University, Jeddah, KSA.
[3]
Hanan Farouk .Aly , Therapeutic Chemistry Dep., National Research Center, Cairo, Egypt.
[4]
Naeema Hamed. Yarkandi , Chemistry Department, Faculty of Applied Science, Umm Alqura Unicersity, Makkah, KSA.
[5]
Abdellatif Mohamed. Salaheldin , Chemistry Department, Faculty of Applied Science, Umm Alqura Unicersity, Makkah, KSA; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
A facile two-step conversion of 3-cyanoacetyl indole to the corresponding 5´-cyanomeridianin C and G analogues by treatment with dimethylformamide-dimethylacetal and further cyclization of the resulting enaminonitrile with amino-guanidine under microwave irradiation is described. The biological evaluation against a range of cancer cells lines demonstrated that cyanomeridianin C 4b is the most cytotoxic compound against lung carcinoma cell line (A549) with inhibition activity of 94.2 % and it has the powerful antioxidant activities. While the enaminonitrile 3b exhibited the highest cytotoxic activity against breast adenocarcinoma (MCF7), lung carcinoma cell line (A549) and human hepatocellular carcinoma cell line (HCT116) with 100, 89.2 and 72.8 % inhibition in cell viability, respectively.
Indole, Enaminonitrile, Meridianines, Microwave, Natural Products
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