Spectrum of Opportunistic Mould Infections in Suspected Pulmonary Tuberculosis (TB) Patients
[1]
Yahaya H., Department of Medical Laboratory Science, Faculty of Allied Health Sciences Bayero University, Kano, Nigeria.
[2]
Taura D. W., Department of Microbiology, Faculty of Science, Bayero University, Kano, Nigeria.
[3]
Aliyu I. A., Department of Medical Laboratory Science, Faculty of Allied Health Sciences Bayero University, Kano, Nigeria.
[4]
Bala J. A., Department of Medical Laboratory Science, Faculty of Allied Health Sciences Bayero University, Kano, Nigeria.
[5]
Yunusa I., Department of Biochemistry, Faculty of Science, Kano University of Science and Technology, Wudil, Kano, Nigeria.
[6]
Ahmad I. M., Department of Biochemistry, Faculty of Science, Kano University of Science and Technology, Wudil, Kano, Nigeria.
[7]
Ali B., Dept of Biology, Faculty of Applied and Natural Sciences, Jigawa State University, Kafin Hausa, Jigawa, Nigeria.
The opportunistic fungi are potential pathogens in the immunocompromised patients, those with the pre – existing disease and long history of antibiotics. The study was designed to document the prevalence of TB associated with respiratory mould infections in Dambatta Kano, Nigeria. The study included induced sputum samples from 300 patients with complaints of symptoms suggestive of Tuberculosis (TB) infections. The TB was diagnosed by sputum Ziehl – Neelsen staining technique. Identification of Mould isolates was done by direct microscopy and culture on two sets of SDA and Corn Meal Agar. Of the 300 sputum samples examined, 28(9.3%) patients were positive to AFB microscopy while fourteen different species were isolated from 26(8.7%) patients mainly caused by the genus Aspergillus. A. niger was isolated in 3(1%) of the patients, while A. fumigatus, A. nudilans and A. terreus were isolated from 3(1%), 1(0.3%) and 2(0.6%) patients respectively. Other fungal agents isolated include, Penicillium viridicatum 3(1%), Rhizopus oryzae 3(1%), Rhizomucor pusillus 1(0.3%). The genus Fusarium had the prevalence of 5(1.5%) comprising of F. oxysporum 2(0.6%), F. nivale 2(0.6%) and F. tricinctum 1(0.3%). The genus Trichophyton had a prevalence of 3(1%) consisting of T. concentricum 1(0.3%) and T. rubrum 2(0.6%). The least prevalence of 1(0.3%) was observed in Malbranchea saccardo and Phoma saccardo respectively. Mould and TB co – infection was 5(1.6%) with male patients having 4(1.3%) while females had 1(0.3%) (P = 0.06145). Co – infection of mould and TB exists and the prevalence of array of these mould species is apparently important considering the immunocompromised status and inadequate response to anti – tubercular drugs of these patients.
Mould, Rhizomucor, Tuberculosis, Mycoses, Infection, Dambatta
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